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@article{Martinón-Torres:2018:10.1016/S2352-4642(18)30113-5,
author = {Martinón-Torres, F and Salas, A and Rivero-Calle, I and Cebey-López, M and Pardo-Seco, J and Herberg, JA and Boeddha, NP and Klobassa, DS and Secka, F and Paulus, S and de, Groot R and Schlapbach, LJ and Driessen, GJ and Anderson, ST and Emonts, M and Zenz, W and Carrol, ED and Van, der Flier M and Levin, M and Levin, M and Coin, L and Gormley, S and Hamilton, S and Herberg, J and Hourmat, B and Hoggart, C and Kaforou, M and Sancho-Shimizu, V and Wright, V and Abdulla, A and Agapow, P and Bartlett, M and Bellos, E and Eleftherohorinou, H and Galassini, R and Inwald, D and Mashbat, M and Menikou, S and Mustafa, S and Nadel, S and Rahman, R and Thakker, C and Bokhandi, S and Power, S and Barham, H and Pathan, N and Ridout, J and White, D and Thurston, S and Faust, S and Patel, S and McCorkell, J and Davies, P and Crate, L and Navarra, H and Carter, S and Ramaiah, R and Patel, R and Tuffrey, C and Gribbin, A and McCready, S and Peters, M and Hardy, K and Standing, F and O'Neill, L and Abe},
doi = {10.1016/S2352-4642(18)30113-5},
journal = {Lancet Child and Adolescent Health},
pages = {404--414},
title = {Life-threatening infections in children in Europe (the EUCLIDS Project): a prospective cohort study},
url = {http://dx.doi.org/10.1016/S2352-4642(18)30113-5},
volume = {2},
year = {2018}
}

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TY  - JOUR
AB  - Background: Sepsis and severe focal infections represent a substantial disease burden in children admitted to hospital. We aimed to understand the burden of disease and outcomes in children with life-threatening bacterial infections in Europe. Methods: The European Union Childhood Life-threatening Infectious Disease Study (EUCLIDS) was a prospective, multicentre, cohort study done in six countries in Europe. Patients aged 1 month to 18 years with sepsis (or suspected sepsis) or severe focal infections, admitted to 98 participating hospitals in the UK, Austria, Germany, Lithuania, Spain, and the Netherlands were prospectively recruited between July 1, 2012, and Dec 31, 2015. To assess disease burden and outcomes, we collected demographic and clinical data using a secured web-based platform and obtained microbiological data using locally available clinical diagnostic procedures. Findings: 2844 patients were recruited and included in the analysis. 1512 (53·2%) of 2841 patients were male and median age was 39·1 months (IQR 12·4–93·9). 1229 (43·2%) patients had sepsis and 1615 (56·8%) had severe focal infections. Patients diagnosed with sepsis had a median age of 27·6 months (IQR 9·0–80·2), whereas those diagnosed with severe focal infections had a median age of 46·5 months (15·8–100·4; p < 0·0001). Of 2844 patients in the entire cohort, the main clinical syndromes were pneumonia (511 [18·0%] patients), CNS infection (469 [16·5%] ), and skin and soft tissue infection (247 [8·7%]). The causal microorganism was identified in 1359 (47·8%) children, with the most prevalent ones being Neisseria meningitidis (in 259 [9·1%]  patients), followed by Staphylococcus aureus (in 222 [7·8%]), Streptococcus pneumoniae (in 219 [7·7%] ), and group A streptococcus (in 162 [5·7%]). 1070 (37·6%) patients required admis
AU  - Martinón-Torres,F
AU  - Salas,A
AU  - Rivero-Calle,I
AU  - Cebey-López,M
AU  - Pardo-Seco,J
AU  - Herberg,JA
AU  - Boeddha,NP
AU  - Klobassa,DS
AU  - Secka,F
AU  - Paulus,S
AU  - de,Groot R
AU  - Schlapbach,LJ
AU  - Driessen,GJ
AU  - Anderson,ST
AU  - Emonts,M
AU  - Zenz,W
AU  - Carrol,ED
AU  - Van,der Flier M
AU  - Levin,M
AU  - Levin,M
AU  - Coin,L
AU  - Gormley,S
AU  - Hamilton,S
AU  - Herberg,J
AU  - Hourmat,B
AU  - Hoggart,C
AU  - Kaforou,M
AU  - Sancho-Shimizu,V
AU  - Wright,V
AU  - Abdulla,A
AU  - Agapow,P
AU  - Bartlett,M
AU  - Bellos,E
AU  - Eleftherohorinou,H
AU  - Galassini,R
AU  - Inwald,D
AU  - Mashbat,M
AU  - Menikou,S
AU  - Mustafa,S
AU  - Nadel,S
AU  - Rahman,R
AU  - Thakker,C
AU  - Bokhandi,S
AU  - Power,S
AU  - Barham,H
AU  - Pathan,N
AU  - Ridout,J
AU  - White,D
AU  - Thurston,S
AU  - Faust,S
AU  - Patel,S
AU  - McCorkell,J
AU  - Davies,P
AU  - Crate,L
AU  - Navarra,H
AU  - Carter,S
AU  - Ramaiah,R
AU  - Patel,R
AU  - Tuffrey,C
AU  - Gribbin,A
AU  - McCready,S
AU  - Peters,M
AU  - Hardy,K
AU  - Standing,F
AU  - O'Neill,L
AU  - Abelake,E
AU  - Deep,A
AU  - Nsirim,E
AU  - Pollard,A
AU  - Willis,L
AU  - Young,Z
AU  - Royad,C
AU  - White,S
AU  - Fortune,PM
AU  - Hudnott,P
AU  - Martinón-Torres,F
AU  - Salas,Ellacuriaga A
AU  - Álvez,González F
AU  - Barral-Arca,R
AU  - Cebey-López,M
AU  - Curras-Tuala,MJ
AU  - García,N
AU  - García,Vicente L
AU  - Gómez-Carballa,A
AU  - Gómez,Rial J
AU  - Grela,Beiroa A
AU  - Justicia,Grande A
AU  - Leboráns,Iglesias P
AU  - Martínez,Santos AE
AU  - Martinón-Torres,N
AU  - Martinón,Sánchez JM
AU  - Morillo,Gutiérrez B
DO  - 10.1016/S2352-4642(18)30113-5
EP  - 414
PY  - 2018///
SN  - 2352-4642
SP  - 404
TI  - Life-threatening infections in children in Europe (the EUCLIDS Project): a prospective cohort study
T2  - Lancet Child and Adolescent Health
UR  - http://dx.doi.org/10.1016/S2352-4642(18)30113-5
UR  - http://hdl.handle.net/10044/1/60344
VL  - 2
ER  -

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