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@article{Boeddha:2018:10.1186/s13054-018-2052-7,
author = {Boeddha, NP and Schlapbach, LJ and Driessen, GJ and Herberg, JA and Rivero-Calle, I and Cebey-López, M and Klobassa, DS and Philipsen, R and de, Groot R and Inwald, DP and Nadel, S and Paulus, S and Pinnock, E and Secka, F and Anderson, ST and Agbeko, RS and Berger, C and Fink, CG and Carrol, ED and Zenz, W and Levin, M and van, der Flier M and Martinón-Torres, F and Hazelzet, JA and Emonts, M and EUCLIDS, consortium},
doi = {10.1186/s13054-018-2052-7},
journal = {Critical Care},
title = {Mortality and morbidity in community-acquired sepsis in European pediatric intensive care units: a prospective cohort study from the European Childhood Life-threatening Infectious Disease Study (EUCLIDS)},
url = {http://dx.doi.org/10.1186/s13054-018-2052-7},
volume = {22},
year = {2018}
}

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TY  - JOUR
AB  - BACKGROUND: Sepsis is one of the main reasons for non-elective admission to pediatric intensive care units (PICUs), but little is known about determinants influencing outcome. We characterized children admitted with community-acquired sepsis to European PICUs and studied risk factors for mortality and disability. METHODS: Data were collected within the collaborative Seventh Framework Programme (FP7)-funded EUCLIDS study, which is a prospective multicenter cohort study aiming to evaluate genetic determinants of susceptibility and/or severity in sepsis. This report includes 795 children admitted with community-acquired sepsis to 52 PICUs from seven European countries between July 2012 and January 2016. The primary outcome measure was in-hospital death. Secondary outcome measures were PICU-free days censured at day 28, hospital length of stay, and disability. Independent predictors were identified by multivariate regression analysis. RESULTS: Patients most commonly presented clinically with sepsis without a source (n = 278, 35%), meningitis/encephalitis (n = 182, 23%), or pneumonia (n = 149, 19%). Of 428 (54%) patients with confirmed bacterial infection, Neisseria meningitidis (n = 131, 31%) and Streptococcus pneumoniae (n = 78, 18%) were the main pathogens. Mortality was 6% (51/795), increasing to 10% in the presence of septic shock (45/466). Of the survivors, 31% were discharged with disability, including 24% of previously healthy children who survived with disability. Mortality and disability were independently associated with S. pneumoniae infections (mortality OR 4.1, 95% CI 1.1-16.0, P = 0.04; disability OR 5.4, 95% CI 1.8-15.8, P < 0.01) and illness severity as measured by Pediatric Index of Mortality (PIM2) score (mortality OR 2.8, 95% CI 1.3-6.1, P < 0.01; disability OR 3.4, 95% CI 1.8-6.4, P < 0.001). CONCLUSIONS: Despite wide
AU  - Boeddha,NP
AU  - Schlapbach,LJ
AU  - Driessen,GJ
AU  - Herberg,JA
AU  - Rivero-Calle,I
AU  - Cebey-López,M
AU  - Klobassa,DS
AU  - Philipsen,R
AU  - de,Groot R
AU  - Inwald,DP
AU  - Nadel,S
AU  - Paulus,S
AU  - Pinnock,E
AU  - Secka,F
AU  - Anderson,ST
AU  - Agbeko,RS
AU  - Berger,C
AU  - Fink,CG
AU  - Carrol,ED
AU  - Zenz,W
AU  - Levin,M
AU  - van,der Flier M
AU  - Martinón-Torres,F
AU  - Hazelzet,JA
AU  - Emonts,M
AU  - EUCLIDS,consortium
DO  - 10.1186/s13054-018-2052-7
PY  - 2018///
SN  - 1364-8535
TI  - Mortality and morbidity in community-acquired sepsis in European pediatric intensive care units: a prospective cohort study from the European Childhood Life-threatening Infectious Disease Study (EUCLIDS)
T2  - Critical Care
UR  - http://dx.doi.org/10.1186/s13054-018-2052-7
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29855385
UR  - http://hdl.handle.net/10044/1/60126
VL  - 22
ER  -

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