Imperial College London
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ProfessorMichaelLevin

Faculty of Medicine, Department of Infectious Disease

Chair in Paediatrics & International Child Health
 
 
 
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Contact

 

+44 (0)20 7594 3760m.levin Website

 
 
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Location

 

233Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{von:2015:10.1016/j.vaccine.2015.05.025,
author = {von, Both U and Levin, M and Kaforou, M and Newton, SM},
doi = {10.1016/j.vaccine.2015.05.025},
journal = {Vaccine},
pages = {5289--5293},
title = {Understanding immune protection against tuberculosis using RNA expression profiling.},
url = {http://dx.doi.org/10.1016/j.vaccine.2015.05.025},
volume = {33},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - A major limitation in the development and testing of new tuberculosis (TB) vaccines is the current inadequate understanding of the nature of the immune response required for protection against either infection with Mycobacterium tuberculosis (MTB) or progression to disease. Genome wide RNA expression analysis has provided a new tool with which to study the inflammatory and immunological response to mycobacteria. To explore how currently available transcriptomic data might be used to understand the basis of protective immunity to MTB, we analysed and reviewed published RNA expression studies to (1) identify a “susceptible” immune response in patients with acquired defects in the interferon gamma pathway; (2) identify the “failing” transcriptomic response in patients with TB as compared with latent TB infection (LTBI); and (3) identify elements of the “protective” response in healthy latently infected and healthy uninfected individuals.Abbreviations    TB, tuberculosis; MTB, Mycobacterium tuberculosis; IFN-γ, interferon-gamma; PBMC, peripheral blood mononuclear cells; MSMD, Mendelian susceptibility to mycobacterial disease; BCG, bacille Calmette–Guerin; LTBI, latent tuberculosis infectionKeywords    Transcriptomics; RNA expression profiling; Tuberculosis; Vaccines; Interferon-γ; Type I interferon
AU  - von,Both U
AU  - Levin,M
AU  - Kaforou,M
AU  - Newton,SM
DO  - 10.1016/j.vaccine.2015.05.025
EP  - 5293
PY  - 2015///
SN  - 1873-2518
SP  - 5289
TI  - Understanding immune protection against tuberculosis using RNA expression profiling.
T2  - Vaccine
UR  - http://dx.doi.org/10.1016/j.vaccine.2015.05.025
UR  - http://hdl.handle.net/10044/1/25611
VL  - 33
ER  -
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