Publications
192 results found
Clarke JR, Braganza R, Mirza A, et al., 1999, Rapid development of genotypic resistance to lamivudine when combined with zidovudine in pregnancy, JOURNAL OF MEDICAL VIROLOGY, Vol: 59, Pages: 364-368, ISSN: 0146-6615
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- Citations: 30
Lyall EGH, Patton GS, Sheldon J, et al., 1999, Evidence for horizontal and not vertical transmission of human herpesvirus 8 in children born to human immunodeficiency virus-infected mothers, PEDIATRIC INFECTIOUS DISEASE JOURNAL, Vol: 18, Pages: 795-799, ISSN: 0891-3668
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- Citations: 36
Hill CL, Bieniasz PD, McClure MO, 1999, Properties of human foamy virus relevant to its development as a vector for gene therapy, JOURNAL OF GENERAL VIROLOGY, Vol: 80, Pages: 2003-2009, ISSN: 0022-1317
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- Citations: 79
Prescott LE, MacDonald DM, Davidson F, et al., 1999, Sequence diversity of TT virus in geographically dispersed human populations., J Gen Virol, Vol: 80 ( Pt 7), Pages: 1751-1758, ISSN: 0022-1317
TT virus (TTV) is a newly discovered DNA virus originally classified as a member of the Parvoviridae. TTV is transmitted by blood transfusion where it has been reported to be associated with mild post-transfusion hepatitis. TTV can cause persistent infection, and is widely distributed geographically; we recently reported extremely high prevalences of viraemia in individuals living in tropical countries (e.g. 74% in Papua New Guinea, 83% in Gambia; Prescott & Simmonds, New England Journal of Medicine 339, 776, 1998). In the current study we have compared nucleotide sequences from the N22 region of TTV (222 bases) detected in eight widely dispersed human populations. Some variants of TTV, previously classified as genotypes 1a, 1b and 2, were widely distributed throughout the world, while others, such as a novel subtype of type 1 in Papua New Guinea, were confined to a single geographical area. Five of the 122 sequences obtained in this study (from Gambia, Nigeria, Papua New Guinea, Brazil and Ecuador) could not be classified as types 1, 2 or 3, with the variant from Brazil displaying only 46-50% nucleotide (32-35% amino acid) sequence similarity to other variants. This study provides an indication of the extreme sequence diversity of TTV, a characteristic which is untypical of parvoviruses.
Adams GB, McMullen M, Turner S, et al., 1999, Isolation and transduction of CD34<SUP>+</SUP> cells from small quantities of peripheral blood from HIV-1-infected patients not treated with hemopoietic growth factors, JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, Vol: 21, Pages: 1-8, ISSN: 1077-9450
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- Citations: 3
Clarke JR, McClure MO, 1999, HIV-1 viral load testing, JOURNAL OF INFECTION, Vol: 38, Pages: 141-146, ISSN: 0163-4453
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- Citations: 4
Adams GB, Pym AS, Poznansky MC, et al., 1999, The <i>in vivo</i> effects of combination antiretroviral drug therapy on peripheral blood CD34<SUP>+</SUP> cell colony forming units from HIV type 1 infected patients, AIDS RESEARCH AND HUMAN RETROVIRUSES, Vol: 15, Pages: 551-559, ISSN: 0889-2229
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- Citations: 12
Herchenröder O, Moosmayer D, Bock M, et al., 1999, Specific binding of recombinant foamy virus envelope protein to host cells correlates with susceptibility to infection., Virology, Vol: 255, Pages: 228-236, ISSN: 0042-6822
The interaction of simian foamy viruses (FVs) with their putative cellular receptor(s) was studied with two types of recombinant envelope protein (Env). Transient expression of full-length Env in BHK-21 cells induced syncytia formation. However, selected stable transfectants fused with naive cells but not with each other. A soluble fusion protein of the Env surface domain with the Fc fragment of a human IgG1 heavy chain (EnvSU-Ig) was produced in the baculovirus expression system, purified to homogeneity, and used for binding and competition analyses. EnvSU-Ig but not unrelated Ig fusion proteins bound to cells specifically. Neutralizing serum blocked binding of EnvSU-Ig and, vice versa, serum-mediated neutralization was abrogated by the chimeric protein. Concomitant reduction of EnvSU-Ig binding and FV susceptibility was seen in Env-expressing target cells. Although EnvSU-Ig did not inhibit FV infection, very likely due to its displacement by multivalent virus-cell interactions, this divalent ligand should help to characterize functionally and to identify the ubiquitous FV receptor.
McBride MO, Fischer PB, Sumiya M, et al., 1998, Mannose-binding protein in HIV-seropositive patients does not contribute to disease progression or bacterial infections, INTERNATIONAL JOURNAL OF STD & AIDS, Vol: 9, Pages: 683-688, ISSN: 0956-4624
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- Citations: 28
Clarke JR, Braganza R, Mirza A, et al., 1998, High frequency of resistance mutations in pregnant women on dual antiretroviral therapy, AIDS, Vol: 12, Pages: S20-S20, ISSN: 0269-9370
Patience C, Patton GS, Takeuchi Y, et al., 1998, No evidence of pig DNA or retroviral infection in patients with short-term extracorporeal connection to pig kidneys, LANCET, Vol: 352, Pages: 699-701, ISSN: 0140-6736
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- Citations: 248
Adams NJ, Prescott LE, Jarvis LM, et al., 1998, Detection in chimpanzees of a novel flavivirus related to GB virus-C/hepatitis G virus., J Gen Virol, Vol: 79 ( Pt 8), Pages: 1871-1877, ISSN: 0022-1317
Infection with hepatitis G virus (HGV) or GB virus-C (GBV-C) is widely distributed in human populations. Viruses related to GBV-C/HGV have been recovered from several New World primate species, including tamarins, owl monkeys and marmosets. To understand more about the relationship between GB viruses and their hosts, we used primers from the 5' non-coding (5'NC), non-structural 3 (NS3) and NS5 regions in nested polymerase chain reactions to screen for related viruses infecting non-captive chimpanzees (Pan troglodytes, troglodytes and verus subspecies). Sequences from the 5'NCR and NS5 regions were amplified from samples taken from 3 of 39 chimpanzees, and from one chimpanzee in the NS3 region. Sequence comparisons of each region revealed that the GB virus infecting chimpanzees was distinct from both GBV-C/HGV and from any of the known GBV-A sequences, but was more closely related to human viruses. GB viruses recovered from different chimpanzees were more diverse than variants of GBV-C/HGV found in humans, with 25% sequence divergence in the 5'NCR and 20% (9.5% amino acid) sequence divergence in NS5 between variants recovered from the troglodytes and verus subspecies, compared with 7.4% and 10.4% (1.9% amino acid) divergence amongst GBV-C/HGV variants infecting humans. Finding GBV-C/HGV-related viruses in an Old World monkey species suggests that GB-like viruses may be widely distributed in simians, and suggests a close evolutionary relationship with their natural hosts.
Erlwein O, Bieniasz PD, McClure MO, 1998, Sequences in <i>pol</i> are required for transfer of human foamy virus-based vectors, JOURNAL OF VIROLOGY, Vol: 72, Pages: 5510-5516, ISSN: 0022-538X
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- Citations: 46
Ait-Khaled M, Lyall EGH, Stainsby C, et al., 1998, Intrapartum mucosal exposure to human immunodeficiency virus type 1 (HIV-1) of infants born to HIV-1-infected mothers correlates with maternal plasma virus burden, JOURNAL OF INFECTIOUS DISEASES, Vol: 177, Pages: 1097-1100, ISSN: 0022-1899
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- Citations: 22
Lyall EGH, Stainsby C, Taylor GP, et al., 1998, Review of uptake of interventions to reduce mother to child transmission of HIV by women aware of their HIV status, BRITISH MEDICAL JOURNAL, Vol: 316, Pages: 268-270, ISSN: 0959-8138
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- Citations: 13
Moebes A, Enssle J, Bieniasz PD, et al., 1997, Human foamy virus reverse transcription that occurs late in the viral replication cycle., J Virol, Vol: 71, Pages: 7305-7311, ISSN: 0022-538X
Foamy viruses (FVs) are retroid viruses which use a replication strategy unlike those of other retroviruses and hepadnaviruses (S. F. Yu, D. N. Baldwin, S. R. Gwynn, S. Yendapilli, and M. L. Linial, Science 271:1579-1582, 1996). One of the striking differences between FVs and retroviruses is the presence of large amounts of linear genome-length DNA in FV-infected cells and in virions. We report here that large quantities of genome-length linear FV DNA accumulate in cells infected with FV, as determined by Southern blotting. To determine whether these unintegrated virus DNAs result solely from superinfection, we analyzed the occurrence of virus cDNA of the so-called human FV isolate (HFV) in cells transfected with a virus mutant deficient in the envelope gene and in cells which are resistant to superinfection due to stable expression of the envelope protein. We show that the synthesis of viral cDNA is independent of superinfection and that HFV synthesizes cDNA intracellularly as a late event in the replication cycle. To further confirm this finding, we performed inhibition studies with the reverse transcriptase inhibitor zidovudine (AZT). While AZT had no effect or only a minor effect on virus titers when added to cells prior to virus infection, viral titers were reduced by 3 or 4 orders of magnitude when the virus was produced from cells in the presence of AZT. Our results are most compatible with the hypothesis that the functional nucleic acid of the extracellular HFV consists of largely double-stranded linear DNA.
Bieniasz PD, Erlwein O, Aguzzi A, et al., 1997, Gene transfer using replication-defective human foamy virus vectors, VIROLOGY, Vol: 235, Pages: 65-72, ISSN: 0042-6822
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- Citations: 28
Takeuchi Y, Liong SH, Bieniasz PD, et al., 1997, Sensitization of rhabdo-, lenti-, and spumaviruses to human serum by galactosyl(alpha 1-3)galactosylation, JOURNAL OF VIROLOGY, Vol: 71, Pages: 6174-6178, ISSN: 0022-538X
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- Citations: 63
Aarons E, Fernandez M, Rees A, et al., 1997, CC-chemokine receptor 5 genotypes and in vitro susceptibility to HIV-1 of a cohort of British HIV-exposed uninfected homosexual men, AIDS, Vol: 11, Pages: 688-689, ISSN: 0269-9370
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- Citations: 11
Erlwein O, Cain D, Fischer N, et al., 1997, Identification of sites that act together to direct dimerization of human foamy virus RNA in vitro, VIROLOGY, Vol: 229, Pages: 251-258, ISSN: 0042-6822
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- Citations: 25
Stafford MK, Cain D, Rosenstein I, et al., 1997, A placebo-controlled, double-blind prospective study in healthy female volunteers of dextrin sulphate gel - A novel potential intravaginal virucide, JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY, Vol: 14, Pages: 213-218, ISSN: 1077-9450
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- Citations: 46
Ali M, Taylor GP, Pitman RJ, et al., 1996, No evidence of antibody to human foamy virus in widespread human populations, AIDS RESEARCH AND HUMAN RETROVIRUSES, Vol: 12, Pages: 1473-1483, ISSN: 0889-2229
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- Citations: 51
Horner PJ, Ali M, Parker D, et al., 1996, Antigen capture ELISA for the heat shock protein (hsp60) of Chlamydia trachomatis., J Clin Pathol, Vol: 49, Pages: 642-647, ISSN: 0021-9746
AIMS: To develop an indirect ELISA using the heat shock protein (hsp60) of Chlamydia trachomatis as antigen. METHODS: The hsp60 gene was amplified by PCR, expressed in the vector pDEV-107 and transformed into Escherichia coli. The recombinant protein, expressed as a beta-galactosidase fusion product, was captured onto a solid phase using a monoclonal antibody directed against beta-galactosidase. Following incubation with goat anti-human antibody conjugated to peroxidase and colour development on addition of peroxidase substrate, antibody recognition of antigen was quantified by optical density at 492 nm. RESULTS: A sensitive and relatively specific ELISA to detect hsp60 has been produced, which can be exploited to determine the antibody response to C trachomatis hsp60. CONCLUSIONS: This assay will permit the future investigation of the immunopathogenesis of persistent inflammation following C trachomatis infection.
McClure MO, Goulder PJ, Ogg G, et al., 1996, HIV clearance in infants, LANCET, Vol: 347, Pages: 1122-1122, ISSN: 0140-6736
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- Citations: 2
McClure MO, Erlwein O, 1995, Foamy viruses - Pathogenic or therapeutic potential?, REVIEWS IN MEDICAL VIROLOGY, Vol: 5, Pages: 229-237, ISSN: 1052-9276
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- Citations: 7
Bieniasz PD, Weiss RA, McClure MO, 1995, Cell cycle dependence of foamy retrovirus infection., J Virol, Vol: 69, Pages: 7295-7299, ISSN: 0022-538X
In common with oncoviruses but unlike the lentivirus human immunodeficiency virus type 1, foamy (spuma) viruses require host cell proliferation for productive infection. We show that human immunodeficiency virus type 1 replicates in RD-CD4 cells regardless of the growth arrest condition of the cells, while murine leukemia virus is unable to infect growth-arrested RD-CD4 cells or cells progressing through a partial cell cycle that includes S phase but not mitosis. Human foamy virus, like murine leukemia virus, does not productively infect G1/S or G2 growth-arrested cells. Two other foamy viruses, simian foamy virus type 1, isolated from a macaque, and simian foamy virus type 6, isolated from a chimpanzee, also fail to establish productive infection in G1/S-arrested cells.
ALI M, RETHWILM A, CHEINGSONGPOPOV R, et al., 1995, SEROEPIDEMIOLOGY OF HFV INFECTION, JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY, Vol: 10, Pages: 239-239, ISSN: 1077-9450
MCCLURE MO, BIENIASZ PD, WEBER JN, et al., 1995, HIV CLEARANCE IN AN INFANT, NATURE, Vol: 375, Pages: 637-637, ISSN: 0028-0836
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- Citations: 12
McClure MO, Bieniasz PD, Weber JN, et al., 1995, HIV clearance in an infant?, Nature, Vol: 375, Pages: 637-638, ISSN: 0028-0836
Allen JM, Ali M, McClure MO, 1995, Production of soluble surface glycoprotein, GP70, of the Mason-Pfizer monkey virus in COS cells is dependent on the presence of regions of the transmembrane domain., Biochem Soc Trans, Vol: 23, ISSN: 0300-5127
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