Imperial College London
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PROFESSOR MIRIAM F. MOFFATT

Faculty of Medicine, National Heart & Lung Institute

Consul for the Faculty of Medicine, Professor
 
 
 
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Contact

 

+44 (0)20 7594 2942m.moffatt

 
 
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Location

 

400Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

305 results found

Cardenas PA, Cooper PJ, Cox MJ, Chico M, Arias C, Moffatt MF, Cookson WOet al., 2012, Upper Airways Microbiota in Antibiotic-Naive Wheezing and Healthy Infants from the Tropics of Rural Ecuador, PLOS ONE, Vol: 7, ISSN: 1932-6203

Journal article

Jiang W, Johnson C, Jayaraman J, Simecek N, Noble J, Moffatt MF, Cookson WO, Trowsdale J, Traherne JAet al., 2012, Copy number variation leads to considerable diversity for B but not A haplotypes of the human KIR genes encoding NK cell receptors, Genome Res

Journal article

Wan YI, Shrine NRG, Artigas MS, Wain LV, Blakey JD, Moffatt MF, Bush A, Chung KF, Cookson WOCM, Strachan DP, Heaney L, Al-Momani BAH, Mansur AH, Manney S, Thomson NC, Chaudhuri R, Brightling CE, Bafadhel M, Singapuri A, Niven R, Simpson A, Holloway JW, Howarth PH, Hui J, Musk AW, James AL, Brown MA, Baltic S, Ferreira MAR, Thompson PJ, Tobin MD, Sayers I, Hall IPet al., 2012, Genome-wide association study to identify genetic determinants of severe asthma, THORAX, Vol: 67, Pages: 762-768, ISSN: 0040-6376

Journal article

Dizier M-H, Margaritte-Jeannin P, Madore A-M, Esparza-Gordillo J, Moffatt M, Corda E, Monier F, Guilloud-Bataille M, Franke A, Weidinger S, Annesi-Maesano I, Just J, Pin I, Kauffmann F, Cookson W, Lee Y-A, Laprise C, Lathrop M, Bouzigon E, Demenais Fet al., 2012, The <i>ANO3</i>/<i>MUC15</i> locus is associated with eczema in families ascertained through asthma, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 129, Pages: 1547-+, ISSN: 0091-6749

Journal article

Imboden M, Bouzigon E, Curjuric I, Ramasamy A, Kumar A, Hancock DB, Wilk JB, Vonk JM, Thun GA, Siroux V, Nadif R, Monier F, Gonzalez JR, Wjst M, Heinrich J, Loehr LR, Franceschini N, North KE, Altmueller J, Koppelman GH, Guerra S, Kronenberg F, Lathrop M, Moffatt MF, O'Connor GT, Strachan DP, Postma DS, London SJ, Schindler C, Kogevinas M, Kauffmann F, Jarvis DL, Demenais F, Probst-Hensch NMet al., 2012, Genome-wide association study of lung function decline in adults with and without asthma, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 129, Pages: 1218-1228, ISSN: 0091-6749

Journal article

Zhang M, Liang L, Morar N, Dixon AL, Lathrop GM, Ding J, Moffatt MF, Cookson WOC, Kraft P, Qureshi AA, Han Jet al., 2012, Integrating pathway analysis and genetics of gene expression for genome-wide association study of basal cell carcinoma, HUMAN GENETICS, Vol: 131, Pages: 615-623, ISSN: 0340-6717

Journal article

Sim K, Cox MJ, Wopereis H, Martin R, Knol J, Li MS, Cookson WO, Moffatt MF, Kroll JSet al., 2012, Improved Detection of Bifidobacteria with Optimised 16S rRNA-Gene Based Pyrosequencing, PLoS One, Vol: 7, Pages: e32543-e32543

The 16S rRNA gene is conserved across all bacteria and as such is routinely targeted in PCR surveys of bacterial diversity. PCR primer design aims to amplify as many different 16S rRNA gene sequences from as wide a range of organisms as possible, though there are no suitable 100% conserved regions of the gene, leading to bias. In the gastrointestinal tract, bifidobacteria are a key genus, but are often under-represented in 16S rRNA surveys of diversity. We have designed modified, 'bifidobacteria-optimised' universal primers, which we have demonstrated detection of bifidobacterial sequence present in DNA mixtures at 2% abundance, the lowest proportion tested. Optimisation did not compromise the detection of other organisms in infant faecal samples. Separate validation using fluorescence in situ hybridisation (FISH) shows that the proportions of bifidobacteria detected in faecal samples were in agreement with those obtained using 16S rRNA based pyrosequencing. For future studies looking at faecal microbiota, careful selection of primers will be key in order to ensure effective detection of bifidobacteria.

Journal article

Freidin MB, Bhudia N, Lim E, Nicholson AG, Cookson WO, Moffatt MFet al., 2012, Impact of Collection and Storage of Lung Tumor Tissue on Whole Genome Expression Profiling, JOURNAL OF MOLECULAR DIAGNOSTICS, Vol: 14, Pages: 140-148, ISSN: 1525-1578

Journal article

Sarnowski C, Malerba G, Laprise C, Rohde K, Moffatt M, Jeannin P, Dizier M-H, Pignatti PF, Cookson WOC, Lathrop M, Demenais F, Bouzigon Eet al., 2012, Taking Into Account Imprinting And Maternal Genotype Effects Facilitates Detection Of New Genes, 20th Annual Meeting of the International-Genetic-Epidemiology-Society (IGES), Publisher: WILEY-BLACKWELL, Pages: 122-123, ISSN: 0741-0395

Conference paper

Zhang Y, Moffatt MF, Cookson WOC, 2012, Genetic and genomic approaches to asthma: new insights for the origins, Current Opinion in Pulmonary Medicine, Vol: 18, Pages: 6-13, ISSN: 1070-5287

Purpose of review: The aim is to update current understanding of the genes identified by the recent genome-wide association studies (GWASs) of asthma and its associated traits. The review also discusses how to dissect the functional roles of novel genes in future research.Recent findings: More than 10 GWAS aimed at identifying the genes underlying asthma and relevant traits have been published in the past 3 years. The largest of these was from the GABRIEL consortium, which discovered that the IL18R1, IL33, SMAD3, ORMDL3, HLA-DQ and IL2RB loci were all significantly associated with asthma. Many novel asthma genes, including those previously identified by positional cloning, are expressed within the respiratory epithelium, emphasizing the importance of epithelial barriers in causing asthma . The genes controlling IgE levels have surprisingly little overlap with the genes mediating asthma susceptibility, suggesting that atopy is secondary to asthma rather than a primary driver of the disease. The next challenge will be the systematic analysis of the precise functions of these genes in the pathogenesis of asthma.Summary: GWAS have uncovered many novel genes underlying asthma and detailed functional dissection of their roles in asthma will point the way to new therapies for the disease.

Journal article

Freidin M, Nicholson A, Popat S, Moffatt M, Cookson W, Lim Eet al., 2012, Distribution profile of baseline gene expression to standardise tumour expression: a pilot study of cisplatin resistant genes in lung cancer, Publisher: ELSEVIER IRELAND LTD, Pages: S2-S3, ISSN: 0169-5002

Conference paper

Tulah AS, Parker SG, Moffatt MF, Wardlaw AJ, Connolly MJ, Sayers Iet al., 2011, The role of <i>ALOX5AP</i>, <i>LTA4H</i> and <i>LTB4R</i> polymorphisms in determining baseline lung function and COPD susceptibility in UK smokers, BMC MEDICAL GENETICS, Vol: 12

Journal article

Cox MJ, Jones AL, Loebinger MR, Duff RM, Simmonds NJ, Davies JC, Wilson R, Alton EW, Cookson WOCM, Bilton D, Moffatt MFet al., 2011, MUCOIDY AND THE MICROBIOME: COMMUNITY COMPOSITION IN RELATION TO THE PRESENCE OF CULTURABLE, MUCOID <i>PSEUDOMONAS AERUGINOSA</i>, Winter Meeting of the British-Thoracic-Society, Publisher: B M J PUBLISHING GROUP, Pages: A24-A24, ISSN: 0040-6376

Conference paper

Zhang Q, Liang Z, Gibeon D, Hui CK, Alshafi AK, Menzies-Gow A, Bhavsar PK, Duff R, Moffatt M, Cookson B, Chung KFet al., 2011, PRESENCE OF BACTERIA FROM ASTHMATIC AIRWAYS: RELATIONSHIP TO SEVERITY, RESPIROLOGY, Vol: 16, Pages: 220-221, ISSN: 1323-7799

Journal article

Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, Van der Harst P, Holm H, Sanna S, Kavousi M, Baumeister SE, Coin LJ, Deng G, Gieger C, Heard-Costa NL, Hottenga J-J, Kuehnel B, Kumar V, Lagou V, Liang L, Luan J, Vidal PM, Leach IM, O'Reilly PF, Peden JF, Rahmioglu N, Soininen P, Speliotes EK, Yuan X, Thorleifsson G, Alizadeh BZ, Atwood LD, Borecki IB, Brown MJ, Charoen P, Cucca F, Das D, de Geus EJC, Dixon AL, Doering A, Ehret G, Eyjolfsson GI, Farrall M, Forouhi NG, Friedrich N, Goessling W, Gudbjartsson DF, Harris TB, Hartikainen A-L, Heath S, Hirschfield GM, Hofman A, Homuth G, Hyppoenen E, Janssen HLA, Johnson T, Kangas AJ, Kema IP, Kuehn JP, Lai S, Lathrop M, Lerch MM, Li Y, Liang TJ, Lin J-P, Loos RJF, Martin NG, Moffatt MF, Montgomery GW, Munroe PB, Musunuru K, Nakamura Y, O'Donnell CJ, Olafsson I, Penninx BW, Pouta A, Prins BP, Prokopenko I, Puls R, Ruokonen A, Savolainen MJ, Schlessinger D, Schouten JNL, Seedorf U, Sen-Chowdhry S, Siminovitch KA, Smit JH, Spector TD, Tan W, Teslovich TM, Tukiainen T, Uitterlinden AG, Van der Klauw MM, Vasan RS, Wallace C, Wallaschofski H, Wichmann H-E, Willemsen G, Wuertz P, Xu C, Yerges-Armstrong LM, Abecasis GR, Ahmadi KR, Boomsma DI, Caulfield M, Cookson WO, van Duijn CM, Froguel P, Matsuda K, McCarthy MI, Meisinger C, Mooser V, Pietilainen KH, Schumann G, Snieder H, Sternberg MJE, Stolk RP, Thomas HC, Thorsteinsdottir U, Uda M, Waeber G, Wareham NJ, Waterworth DM, Watkins H, Whitfield JB, Witteman JCM, Wolffenbuttel BHR, Fox CS, Ala-Korpela M, Stefansson K, Vollenweider P, Voelzke H, Schadt EE, Scott J, Jarvelin M-R, Elliott P, Kooner JSet al., 2011, Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma, NATURE GENETICS, Vol: 43, Pages: 1131-1138, ISSN: 1061-4036

Journal article

Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, Steinthorsdottir V, Thorleifsson G, Zillikens MC, Speliotes EK, Maegi R, Workalemahu T, White CC, Bouatia-Naji N, Harris TB, Berndt SI, Ingelsson E, Willer CJ, Weedon MN, Luan J, Vedantam S, Esko T, Kilpelaeinen TO, Kutalik Z, Li S, Monda KL, Dixon AL, Holmes CC, Kaplan LM, Liang L, Min JL, Moffatt MF, Molony C, Nicholson G, Schadt EE, Zondervan KT, Feitosa MF, Ferreira T, Allen HL, Weyant RJ, Wheeler E, Wood AR, Estrada K, Goddard ME, Lettre G, Mangino M, Nyholt DR, Purcell S, Smith AV, Visscher PM, Yang J, McCarroll SA, Nemesh J, Voight BF, Absher D, Amin N, Aspelund T, Coin L, Glazer NL, Hayward C, Heard-Costa NL, Hottenga J-J, Johansson A, Johnson T, Kaakinen M, Kapur K, Ketkar S, Knowles JW, Kraft P, Kraja AT, Lamina C, Leitzmann MF, McKnight B, Morris AP, Ong KK, Perry JRB, Peters MJ, Polasek O, Prokopenko I, Rayner NW, Ripatti S, Rivadeneira F, Robertson NR, Sanna S, Sovio U, Surakka I, Teumer A, van Wingerden S, Vitart V, Zhao JH, Cavalcanti-Proenca C, Chines PS, Fisher E, Kulzer JR, Lecoeur C, Narisu N, Sandholt C, Scott LJ, Silander K, Stark K, Tammesoo M-L, Teslovich TM, Timpson NJ, Watanabe RM, Welch R, Chasman DI, Cooper MN, Jansson J-O, Kettunen J, Lawrence RW, Pellikka N, Perola M, Vandenput L, Alavere H, Almgren P, Atwood LD, Bennett AJ, Biffar R, Bonnycastle LL, Bornstein SR, Buchanan TA, Campbell H, Day INM, Dei M, Doerr M, Elliott P, Erdos MR, Eriksson JG, Freimer NB, Fu M, Gaget S, Geus EJC, Gjesing AP, Grallert H, Graessler J, Groves CJ, Guiducci C, Hartikainen A-L, Hassanali N, Havulinna AS, Herzig K-H, Hicks AA, Hui J, Igl W, Jousilahti P, Jula A, Kajantie E, Kinnunen L, Kolcic I, Koskinen S, Kovacs P, Kroemer HK, Krzelj V, Kuusisto J, Kvaloy K, Laitinen J, Lantieri O, Lathrop GM, Lokki M-L, Luben RN, Ludwig B, McArdle WL, McCarthy A, Morken MA, Nelis M, Neville MJ, Pare G, Parker AN, Peden JF, Pichler I, Pietilaeinen KH, Platou CGP, Pouta A, Ridderstrale M, Samani NJ, Saramies J, Sinisalo Jet al., 2011, Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution, NATURE GENETICS, Vol: 43, Pages: 1164-1164, ISSN: 1061-4036

Journal article

Cookson W, Moffatt M, Strachan DP, 2011, Genetic risks and childhood-onset asthma, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 128, Pages: 266-272, ISSN: 0091-6749

Journal article

Freidin MB, Bhudia N, Lim E, Nicholson AG, Popat S, Cookson WO, Moffatt MFet al., 2011, SAMPLE HANDLING AND PROCESSING ARE CRITICAL FACTORS INFLUENCING THE RESULTS OF WHOLE GENOME GENE EXPRESSION PROFILING IN LUNG CANCER TISSUES, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S373-S374, ISSN: 1556-0864

Conference paper

Freidin MB, Nicholson AG, Lim E, Moffatt MF, Cookson WOet al., 2011, GLOBAL GENE EXPRESSION PROFILING TO IDENTIFY COMMON NETWORKS UNDERLYING LUNG CANCER AND SPECIFIC MARKERS OF DIFFERENT LUNG CANCER HISTOLOGICAL TYPES, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S455-S455, ISSN: 1556-0864

Conference paper

Cookson WOC, Moffatt MF, 2011, Genetics of complex airway disease., Proc Am Thorac Soc, Vol: 8, Pages: 149-153

The past 3 years have seen highly significant genetic effects identified for a wide variety of common complex diseases, including the airway disorders of asthma and chronic obstructive pulmonary disease. It appears that only a portion of the genetically mediated susceptibility to complex diseases has been identified, and there is much left to be discovered. This review briefly describes the results of the genome-wide association studies of asthma and gives an overview of the parallel and increasingly large-scale studies that are taking place with chronic obstructive pulmonary disease. The future impact is discussed of technological advances that allow increasingly large-scale gene expression studies, next-generation sequencing, and genome-wide testing for epigenetic effects. The use of genetic technology to examine the airway microbiota that interact with the mucosa in health and disease is described.

Journal article

Zhang M, Liang L, Morar N, Dixon A, Lathrop M, Abecasis G, Moffatt M, Cookson W, Kraft P, Qureshi A, Han Jet al., 2011, Integrating pathway analysis and genetics of gene expression for genome-wide association study on basal cell carcinoma, CANCER RESEARCH, Vol: 71, ISSN: 0008-5472

Journal article

Holt RJ, Zhang Y, Binia A, Dixon AL, Vandiedonck C, Cookson WO, Knight JC, Moffatt MFet al., 2011, Allele-specific transcription of the asthma-associated PHD finger protein 11 gene (PHF11) modulated by octamer-binding transcription factor 1 (Oct-1)., Journal of Allergy and Clinical Immunology, Vol: 127, Pages: 1054-1062.e2, ISSN: 0091-6749

Asthma is a common, chronic inflammatory airway disease of major public health importance with multiple genetic determinants. Previously, we found by positional cloning that PHD finger protein 11 (PHF11) on chromosome 13q14 modifies serum immunoglobulin E (IgE) concentrations and asthma susceptibility. No coding variants in PHF11 were identified.ObjectiveHere we investigate the 3 single nucleotide polymorphisms (SNPs) in this gene most significantly associated with total serum IgE levels—rs3765526, rs9526569, and rs1046295—for a role in transcription factor binding.MethodsWe used electrophoretic mobility shift assays to examine the effect of the 3 SNPs on transcription factor binding in 3 cell lines relevant to asthma pathogenesis. Relative preferential expression of alleles was investigated by using the allelotyping method.ResultsElectrophoretic mobility shift assays show that rs1046295 modulates allele-specific binding by the octamer-binding transcription factor 1 (Oct-1). Analysis of the relative expression levels of the 2 alleles of this SNP in heterozygous individuals showed a modest, but highly significant (P = 6.5 × 10−16), preferential expression of the A allele consistent with a functional role for rs1046295.ConclusionThese results suggest a mechanism by which rs1046295 may act as a regulatory variant modulating transcription at this locus and altering asthma susceptibility.

Journal article

Ege MJ, Strachan DP, Cookson WOCM, Moffatt MF, Gut I, Lathrop M, Kabesch M, Genuneit J, Buechele G, Sozanska B, Boznanski A, Cullinan P, Horak E, Bieli C, Braun-Fahrlaender C, Heederik D, von Mutius Eet al., 2011, Gene-environment interaction for childhood asthma and exposure to farming in Central Europe, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 127, Pages: 138-U226, ISSN: 0091-6749

Journal article

Thompson AR, Natanek SA, Willis-Owen SA, Cookson WO, Polkey MI, Moffatt MFet al., 2011, Gene Expression Profiling Of Quadriceps Femoris Muscle In COPD, Publisher: AMER THORACIC SOC, ISSN: 1073-449X

Conference paper

Wan YI, Soler-Artigas M, Shrine NRG, Wain LV, Tobin MD, Moffatt MF, Bush A, Cookson WO, Strachan D, Heaney L, Al-Momani BAH, Mansur AH, Manney S, Thomson N, Chaudhuri R, Brightling CE, Bafadhel M, Singapuri A, Niven R, Simpson A, Holloway JW, Howarth PH, Sayers I, Hall IPet al., 2011, Genome-Wide Association Study To Identify Genetic Determinants Of Severe Asthma (AUGOSA), Publisher: AMER THORACIC SOC, ISSN: 1073-449X

Conference paper

Molyneaux PL, Mallia P, Duff RM, Moffatt MF, Cookson WO, Johnston SLet al., 2011, Investigating The Role Of Rhinovirus Infection In Precipitating Bacterial Infections In COPD Using Culture Independent Molecular Microbiology, Publisher: AMER THORACIC SOC, ISSN: 1073-449X

Conference paper

Cox MJ, Duff RM, Simmonds NJ, Davies J, Wilson R, Alton E, Pantolidis P, Cookson WO, Bilton D, Moffatt MFet al., 2011, Comparison Of The Microbiomes Of Two Chronic Airway Diseases Using High-Throughput Sequencing, Publisher: AMER THORACIC SOC, ISSN: 1073-449X

Conference paper

Wan YI, Shrine NRG, Soler-Artigas M, Wain LV, Moffatt MF, Bush A, Cookson WO, Strachan DP, Heaney L, Al-Momani BAH, Mansur AH, Manney S, Thomson NC, Chaudhuri R, Brightling CE, Bafadhel M, Singapuri A, Niven R, Simpson A, Holloway JW, Howarth PH, Hui J, Musk AW, James AL, Tobin MD, Sayers I, Hall IPet al., 2011, Comprehensive Evaluation Of Mild-To-Moderate Asthma Genes In Severe Asthma (AUGOSA), Publisher: AMER THORACIC SOC, ISSN: 1073-449X

Conference paper

Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, Steinthorsdottir V, Thorleifsson G, Zillikens MC, Speliotes EK, Maegi R, Workalemahu T, White CC, Bouatia-Naji N, Harris TB, Berndt SI, Ingelsson E, Willer CJ, Weedon MN, Luan J, Vedantam S, Esko T, Kilpelaeinen TO, Kutalik Z, Li S, Monda KL, Dixon AL, Holmes CC, Kaplan LM, Liang L, Min JL, Moffatt MF, Molony C, Nicholson G, Schadt EE, Zondervan KT, Feitosa MF, Ferreira T, Allen HL, Weyant RJ, Wheeler E, Wood AR, Estrada K, Goddard ME, Lettre G, Mangino M, Nyholt DR, Purcell S, Smith AV, Visscher PM, Yang J, McCarroll SA, Nemesh J, Voight BF, Absher D, Amin N, Aspelund T, Coin L, Glazer NL, Hayward C, Heard-Costa NL, Hottenga J-J, Johansson A, Johnson T, Kaakinen M, Kapur K, Ketkar S, Knowles JW, Kraft P, Kraja AT, Lamina C, Leitzmann MF, McKnight B, Morris AP, Ong KK, Perry JRB, Peters MJ, Polasek O, Prokopenko I, Rayner NW, Ripatti S, Rivadeneira F, Robertson NR, Sanna S, Sovio U, Surakka I, Teumer A, van Wingerden S, Vitart V, Zhao JH, Cavalcanti-Proenca C, Chines PS, Fisher E, Kulzer JR, Lecoeur C, Narisu N, Sandholt C, Scott LJ, Silander K, Stark K, Tammesoo M-L, Teslovich TM, Timpson NJ, Watanabe RM, Welch R, Chasman DI, Cooper MN, Jansson J-O, Kettunen J, Lawrence RW, Pellikka N, Perola M, Vandenput L, Alavere H, Almgren P, Atwood LD, Bennett AJ, Biffar R, Bonnycastle LL, Bornstein SR, Buchanan TA, Campbell H, Day INM, Dei M, Doerr M, Elliott P, Erdos MR, Eriksson JG, Freimer NB, Fu M, Gaget S, Geus EJC, Gjesing AP, Grallert H, Graessler J, Groves CJ, Guiducci C, Hartikainen A-L, Hassanali N, Havulinna AS, Herzig K-H, Hicks AA, Hui J, Igl W, Jousilahti P, Jula A, Kajantie E, Kinnunen L, Kolcic I, Koskinen S, Kovacs P, Kroemer HK, Krzelj V, Kuusisto J, Kvaloy K, Laitinen J, Lantieri O, Lathrop GM, Lokki M-L, Luben RN, Ludwig B, McArdle WL, McCarthy A, Morken MA, Nelis M, Neville MJ, Pare G, Parker AN, Peden JF, Pichler I, Pietilainen KH, Platou CGP, Pouta A, Ridderstrale M, Samani NJ, Saramies J, Sinisalo J Set al., 2010, Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution, NATURE GENETICS, Vol: 42, Pages: 949-U160, ISSN: 1061-4036

Journal article

Altshuler D, Durbin RM, Abecasis GR, Bentley DR, Chakravarti A, Clark AG, Collins FS, De la Vega FM, Donnelly P, Egholm M, Flicek P, Gabriel SB, Gibbs RA, Knoppers BM, Lander ES, Lehrach H, Mardis ER, McVean GA, Nickerson D, Peltonen L, Schafer AJ, Sherry ST, Wang J, Wilson RK, Gibbs RA, Deiros D, Metzker M, Muzny D, Reid J, Wheeler D, Wang J, Li J, Jian M, Li G, Li R, Liang H, Tian G, Wang B, Wang J, Wang W, Yang H, Zhang X, Zheng H, Lander ES, Altshuler DL, Ambrogio L, Bloom T, Cibulskis K, Fennell TJ, Gabriel SB, Jaffe DB, Shefler E, Sougnez CL, Bentley DR, Gormley N, Humphray S, Kingsbury Z, Koko-Gonzales P, Stone J, McKernan KJ, Costa GL, Ichikawa JK, Lee CC, Sudbrak R, Lehrach H, Borodina TA, Dahl A, Davydov AN, Marquardt P, Mertes F, Nietfeld W, Rosenstiel P, Schreiber S, Soldatov AV, Timmermann B, Tolzmann M, Egholm M, Affourtit J, Ashworth D, Attiya S, Bachorski M, Buglione E, Burke A, Caprio A, Celone C, Clark S, Conners D, Desany B, Gu L, Guccione L, Kao K, Kebbel A, Knowlton J, Labrecque M, McDade L, Mealmaker C, Minderman M, Nawrocki A, Niazi F, Pareja K, Ramenani R, Riches D, Song W, Turcotte C, Wang S, Mardis ER, Dooling D, Fulton L, Fulton R, Weinstock G, Durbin RM, Burton J, Carter DM, Churcher C, Coffey A, Cox A, Palotie A, Quail M, Skelly T, Stalker J, Swerdlow HP, Turner D, De Witte A, Giles S, Gibbs RA, Wheeler D, Bainbridge M, Challis D, Sabo A, Yu F, Yu J, Wang J, Fang X, Guo X, Li R, Li Y, Luo R, Tai S, Wu H, Zheng H, Zheng X, Zhou Y, Yang H, Marth GT, Garrison EP, Huang W, Indap A, Kural D, Lee W-P, Leong WF, Huang W, Indap A, Kural D, Lee W-P, Leong WF, Quinlan AR, Stewart C, Stromberg MP, Ward AN, Wu J, Lee C, Mills RE, Shi X, Daly MJ, DePristo MA, Altshuler DL, Ball AD, Banks E, Bloom T, Browning BL, Cibulskis K, Fennell TJ, Garimella KV, Grossman SR, Handsaker RE, Hanna M, Hartl C, Jaffe DB, Kernytsky AM, Korn JM, Li H, Maguire JR, McCarroll SA, McKenna A, Nemesh JC, Philippakis AA, Poplin RE, Price A, Rivas MA, Sabeti PC, Schaffner SFet al., 2010, A map of human genome variation from population-scale sequencing, NATURE, Vol: 467, Pages: 1061-1073, ISSN: 0028-0836

Journal article

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