Imperial College London
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PROFESSOR MIRIAM F. MOFFATT

Faculty of Medicine, National Heart & Lung Institute

Consul for the Faculty of Medicine, Professor
 
 
 
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Contact

 

+44 (0)20 7594 2942m.moffatt

 
 
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Location

 

400Guy Scadding BuildingRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

305 results found

Binia A, Khorasani N, Bhavsar PK, Adcock I, Brightling CE, Chung KF, Cookson WOC, Moffatt MFet al., 2010, Chromosome 17q21 SNP and severe asthma, Journal of Human Genetics, Vol: 56, Pages: 97-98, ISSN: 1435-232X

Journal article

Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU, Lango Allen H, Lindgren CM, Luan J, Magi R, Randall JC, Vedantam S, Winkler TW, Qi L, Workalemahu T, Heid IM, Steinthorsdottir V, Stringham HM, Weedon MN, Wheeler E, Wood AR, Ferreira T, Weyant RJ, Segre AV, Estrada K, Liang L, Nemesh J, Park JH, Gustafsson S, Kilpelainen TO, Yang J, Bouatia-Naji N, Esko T, Feitosa MF, Kutalik Z, Mangino M, Raychaudhuri S, Scherag A, Smith AV, Welch R, Zhao JH, Aben KK, Absher DM, Amin N, Dixon AL, Fisher E, Glazer NL, Goddard ME, Heard-Costa NL, Hoesel V, Hottenga JJ, Johansson A, Johnson T, Ketkar S, Lamina C, Li S, Moffatt MF, Myers RH, Narisu N, Perry JR, Peters MJ, Preuss M, Ripatti S, Rivadeneira F, Sandholt C, Scott LJ, Timpson NJ, Tyrer JP, van Wingerden S, Watanabe RM, White CC, Wiklund F, Barlassina C, Chasman DI, Cooper MN, Jansson JO, Lawrence RW, Pellikka N, Prokopenko I, Shi J, Thiering E, Alavere H, Alibrandi MT, Almgren P, Arnold AM, Aspelund T, Atwood LD, Balkau B, Balmforth AJ, Bennett AJ, Ben-Shlomo Y, Bergman RN, Bergmann S, Biebermann H, Blakemore AI, Boes T, Bonnycastle LL, Bornstein SR, Brown MJ, Buchanan TAet al., 2010, Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index, Nature Genetics, Vol: 42, Pages: 937-948, ISSN: 1546-1718

Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and approximately 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 x 10(-)(8)), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.

Journal article

DeWan AT, Triche EW, Xu X, Hsu L-I, Zhao C, Belanger K, Hellenbrand K, Willis-Owen SAG, Moffatt M, Cookson WOC, Himes BE, Weiss ST, Gauderman WJ, Baurley JW, Gilliland F, Wilk JB, O'Connor GT, Strachan DP, Hoh J, Bracken MBet al., 2010, <i>PDE11A</i> associations with asthma: Results of a genome-wide association scan, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 126, Pages: 871-U321, ISSN: 0091-6749

Journal article

Moffatt MF, Gut IG, Demenais F, Strachan DP, Bouzigon E, Heath S, von Mutius E, Farrall M, Lathrop M, Cookson WOCM, Kumar A, Burney P, Jarvis D, Wjst M, Kogevinas M, Jogi R, Janson C, Franklin KA, Omenaas E, Leynaert B, Pin I, Heinrich J, Probst-Hensch NM, Anto JM, Sunyer J, Maldonado J-A, Martinez-Moratalla J, Urrutia I, Payo F, Kauffmann F, Dizier M-H, Siroux V, Boznanski A, Braun-Fahrlaender C, Genuneit J, Glas J, Horak E, Kabesch M, Pillai SG, Helms PJ, Carlsen K, Carlsen K-H, Gerritsen J, Silverman M, Sly P, Tsanakas J, Von Berg A, Whyte M, Blumenthal M, Imboden M, Rochat T, Thun GA, Gerbase MW, Curjuric I, Gaspoz J-M, Liu L-JS, Wouters IM, Sigsgaard T, Heederik D, Basinas I, Schlunssen V, Omland O, Cullinan P, Vermeulen R, Henderson J, Granell R, McArdle WL, Smith GD, James AL, Hui J, Palmer LJ, Beilby J, Musk AW, Laprise C, Hudson TJ, Lemire M, Daley D, Becker A, Chan-Yeung M, Sandford A, Kozyrskyj AL, Pare P, Ferguson A, Dimich-Ward H, Watson WT, Freidin MB, Bragina EI, Deev IA, Deeva EV, Kobyakova OS, Puzyrev VP, Ogorodova LM, Khusnutdinova EK, Karunas AS, Fedorova YY, Hall IP, Sayers I, Tobin MD, Wan YI, Heaney LG, Al-Momani BAH, Mansur AH, Manney S, Thomson NC, Chaudhuri R, Brightling CE, Bafadhel M, Singapuri A, Niven R, Simpson A, Holloway JW, Howarth PH, Polonikov AV, Ivanov VP, Solodilova MA, Melen E, Pershagen G, Bergstroem A, Kull I, Nyberg F, Wickman M, Soderhall C, Kere J, Postma DS, Kerkhof M, Brunekreef B, Smit HA, de Jongste JC, Wijga A, Aalberse RC, Hoekstra MO, Koppelman GH, Binia A, Chung KF, Bhavsar P, Chow F, Macedo P, Menzies-Gow A, van Stiphout N, Bush A, Lee Y-A, Esparza-Gordillo J, Nickel R, Wahn U, Lau S, Marenholz I, Haahtela T, von Hertzen L, Jousilahti P, Laatikainen T, Makela MJ, Vartiainen E, Laitinen T, Balding DJ, Peden JF, Corda E, Lechner D, Besse C, Zelenika D, Boland A, Bacq D, Demonchy S, Blanche H, Kamatani Y, von Mutius E, Farrall M, Lathrop M, Cookson WOCMet al., 2010, A Large-Scale, Consortium-Based Genomewide Association Study of Asthma, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 363, Pages: 1211-1221, ISSN: 0028-4793

Journal article

Hsu Y-H, Zillikens MC, Wilson SG, Farber CR, Demissie S, Soranzo N, Bianchi EN, Grundberg E, Liang L, Richards JB, Estrada K, Zhou Y, van Nas A, Moffatt MF, Zhai G, Hofman A, van Meurs JB, Pols HAP, Price RI, Nilsson O, Pastinen T, Cupples LA, Lusis AJ, Schadt EE, Ferrari S, Uitterlinden AG, Rivadeneira F, Spector TD, Karasik D, Kiel DPet al., 2010, An Integration of Genome-Wide Association Study and Gene Expression Profiling to Prioritize the Discovery of Novel Susceptibility Loci for Osteoporosis-Related Traits, PLOS GENETICS, Vol: 6, ISSN: 1553-7404

Journal article

Bouzigon E, Forabosco P, Koppelman GH, Cookson WOCM, Dizier M-H, Duffy DL, Evans DM, Ferreira MAR, Kere J, Laitinen T, Malerba G, Meyers DA, Moffatt M, Martin NG, Ng MY, Pignatti PF, Wjst M, Kauffmann F, Demenais F, Lewis CMet al., 2010, Meta-analysis of 20 genome-wide linkage studies evidenced new regions linked to asthma and atopy., Eur J Hum Genet, Vol: 18, Pages: 700-706

Asthma is caused by a heterogeneous combination of environmental and genetic factors. In the context of GA2LEN (Global Allergy and Asthma European Network), we carried out meta-analyses of almost all genome-wide linkage screens conducted to date in 20 independent populations from different ethnic origins (>or=3024 families with >or=10 027 subjects) for asthma, atopic asthma, bronchial hyper-responsiveness and five atopy-related traits (total immunoglobulin E level, positive skin test response (SPT) to at least one allergen or to House Dust Mite, quantitative score of SPT (SPTQ) and eosinophils (EOS)). We used the genome scan meta-analysis method to assess evidence for linkage within bins of traditionally 30-cM width, and explored the manner in which these results were affected by bin definition. Meta-analyses were conducted in all studies and repeated in families of European ancestry. Genome-wide evidence for linkage was detected for asthma in two regions (2p21-p14 and 6p21) in European families ascertained through two asthmatic sibs. With regard to atopy phenotypes, four regions reached genome-wide significance: 3p25.3-q24 in all families for SPT and three other regions in European families (2q32-q34 for EOS, 5q23-q33 for SPTQ and 17q12-q24 for SPT). Tests of heterogeneity showed consistent evidence of linkage of SPTQ to 3p11-3q21, whereas between-study heterogeneity was detected for asthma in 2p22-p13 and 6p21, and for atopic asthma in 1q23-q25. This large-scale meta-analysis provides an important resource of information that can be used to prioritize further fine-mapping studies and also be integrated with genome-wide association studies to increase power and better interpret the outcomes of these studies.

Journal article

Bouzigon E, Forabosco P, Koppelman GH, Cookson WOCM, Dizier M-H, Duffy DL, Evans DM, Ferreira MAR, Kere J, Laitinen T, Malerba G, Meyers DA, Moffatt M, Martin NG, Ng MY, Pignatti PF, Wjst M, Kauffmann F, Demenais F, Lewis CMet al., 2010, Meta-analysis of 20 genome-wide linkage studies evidenced new regions linked to asthma and atopy, EUROPEAN JOURNAL OF HUMAN GENETICS, Vol: 18, Pages: 700-706, ISSN: 1018-4813

Journal article

Beghe B, Hall IP, Parker SG, Moffatt MF, Wardlaw A, Connolly MJ, Fabbri LM, Ruse C, Sayers Iet al., 2010, Polymorphisms in IL13 pathway genes in asthma and chronic obstructive pulmonary disease, ALLERGY, Vol: 65, Pages: 474-481, ISSN: 0105-4538

Journal article

Harper JI, Godwin H, Green A, Wilkes LE, Holden NJ, Moffatt M, Cookson WO, Layton G, Chandler Set al., 2010, A study of matrix metalloproteinase expression and activity in atopic dermatitis using a novel skin wash sampling assay for functional biomarker analysis, BRITISH JOURNAL OF DERMATOLOGY, Vol: 162, Pages: 397-403, ISSN: 0007-0963

Journal article

Mathias RA, Grant AV, Rafaels N, Hand T, Gao L, Vergara C, Tsai YJ, Yang M, Campbell M, Foster C, Gao P, Togias A, Hansel NN, Diette G, Adkinson NF, Liu MC, Faruque M, Dunston GM, Watson HR, Bracken MB, Hoh J, Maul P, Maul T, Jedlicka AE, Murray T, Hetmanski JB, Ashworth R, Ongaco CM, Hetrick KN, Doheny KF, Pugh EW, Rotimi CN, Ford J, Eng C, Burchard EG, Sleiman PMA, Hakonarson H, Forno E, Raby BA, Weiss ST, Scott AF, Kabesch M, Liang L, Abecasis G, Moffatt MF, Cookson WOC, Ruczinski I, Beaty TH, Barnes KCet al., 2010, A genome-wide association study on African-ancestry populations for asthma, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 125, Pages: 336-346, ISSN: 0091-6749

Journal article

Sleiman PMA, Flory J, Imielinski M, Bradfield JP, Annaiah K, Willis-Owen SAG, Wang K, Rafaels NM, Michel S, Bonnelykke K, Zhang H, Kim CE, Frackelton EC, Glessner JT, Hou C, Otieno FG, Santa E, Thomas K, Smith RM, Glaberson WR, Garris M, Chiavacci RM, Beaty TH, Ruczinski I, Orange JM, Allen J, Spergel JM, Grundmeier R, Mathias RA, Christie JD, von Mutius E, Cookson WOC, Kabesch M, Moffatt MF, Grunstein MM, Barnes KC, Devoto M, Magnusson M, Li H, Grant SFA, Bisgaard H, Hakonarson Het al., 2010, Variants of <i>DENND1B</i> Associated with Asthma in Children, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 362, Pages: 36-44, ISSN: 0028-4793

Journal article

Hilty M, Burke C, Pedro H, Cardenas P, Bush A, Bossley C, Davies J, Ervine A, Poulter L, Pachter L, Moffatt MF, Cookson WOCet al., 2010, Disordered Microbial Communities in Asthmatic Airways, PLOS ONE, Vol: 5, ISSN: 1932-6203

Journal article

Hsu Y-H, Zillikens MC, Wilson SG, Farber CR, Demissie S, Bianchi EN, Liang L, Richards JB, Estrada K, Zhou Y, Soranzo N, van Nas A, Moffatt MF, Zhai G, Hofman A, van Meurs JB, Price RI, Cupples LA, Lusis AJ, Schadt EE, Ferrari S, Uitterlinden AG, Rivadeneira F, Spector TD, Karasik D, Kiel DPet al., 2009, An Integration of Genome-Wide Association Study and Gene Expression Profiling to Prioritize the Discovery of Novel Susceptibility Loci for Osteoporosis Related Traits, 18th Annual Meeting of the International-Genetic-Epidemiology-Society, Publisher: WILEY-LISS, Pages: 752-753, ISSN: 0741-0395

Conference paper

Genuneit J, Cantelmo JL, Weinmayr G, Wong GWK, Cooper PJ, Riikjaerv M-A, Gotua M, Kabesch M, von Mutius E, Forastiere F, Crane J, Nystad W, El-Sharif N, Batlles-Garrido J, Garcia-Marcos L, Garcia-Hernandez G, Morales-Suarez-Varela M, Nilsson L, Braback L, Saraclar Y, Weiland SK, Cookson WOC, Strachan D, Moffatt MFet al., 2009, A multi-centre study of candidate genes for wheeze and allergy: the International Study of Asthma and Allergies in Childhood Phase 2, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 39, Pages: 1875-1888, ISSN: 0954-7894

Journal article

Taylor JM, Street TL, Hao L, Copley R, Taylor MS, Hayden PJ, Stolper G, Mott R, Hein J, Moffatt MF, Cookson WOCMet al., 2009, Dynamic and Physical Clustering of Gene Expression during Epidermal Barrier Formation in Differentiating Keratinocytes, PLOS ONE, Vol: 4, ISSN: 1932-6203

Journal article

Zhang Y, Cookson W, Moffatt M, 2009, Pharmacogenetics and Pharmacogenomics of Airway Diseases, Pharmacology and Therapeutics of Airway Disease, Editors: Barnes, Chung, Publisher: Taylor & Francis Group

I. Introduction Asthma and chronic obstructive pulmonary disease (COPD) are complex syndromes of airway inflammation. Asthma is a disease of the small airways of the lung. Intermittent narrowing of the respiratory bronchioles produces airway limitation and the symptoms of wheezing, chest tightness, and breathlessness. By contrast, in COPD the limitation of airflow is poorly reversible and usually gets progressively worse over time. The disease is primarily, but not exclusively, seen in smokers and former smokers. Environmental and genetic factors contribute to the etiology of both diseases. Cigarette smoking is the main risk factor for COPD, although less than 20% of chronic heavy smokers will develop symptoms of airway obstruction (1). Bronchodilators and corticosteroids are currently the most common medications used in the treatment of asthma and COPD.

Book chapter

GaoJ, Li W, Willis-Owen SA, Jiang L, Guan K, Tian X, Moffatt M, Cookson W, Lin Y, Zhang Y 2010et al., 2009, Polymorphisms of PHF11 and DPP10 are associated with asthma and related traits in a Chinese population., Respiration, Vol: 79, Pages: 17-24, ISSN: 1423-0356

Background: Initial studies by positional cloning have identified the genes encoding the plant homeodomain zinc finger protein 11 (PHF11) and dipeptidyl-peptidase 10 (DPP10) as asthma susceptibility genes. The variants in the two genes have been associated with asthma in several populations of European or Latin American origin. Objective: The aim of this study was to assess the common PHF11 and DPP10 polymorphisms for associations to asthma and asthma-related traits in a Han Chinese population. Methods: We genotyped six polymorphic markers in PHF11 and five polymorphic markers in DPP10 in a Han Chinese case-control cohort consisting of 408 asthma patients and 288 unrelated disease-free controls recruited from the Northern region of China. We analyzed the association between these markers and asthma as well as a number of intermediate, asthma-related traits. Linkage disequilibrium and haplotype patterns were also evaluated. Results: Significant associations were identified between two makers in PHF11 (rs1046295 and rs16659) and asthma susceptibility (odds ratio, OR = 1.32, 95% con fidence interval, CI = 1.06–1.65, p = 0.0096, for rs1046295, and OR = 1.41, 95% CI = 1.12–1.75, p = 0.0026, for rs16659). A strong association was observed between an SNP in DPP10 (rs10208402) and loge-transformed total IgE (p = 0.0003) and the percentage of peripheral blood eosinophils (p = 0.0023). A weak association between rs1430090 in DPP10 and forced expiratory volume in 1 s was also observed (p = 0.048). Haplotype analysis revealed two protective haplotypes in PHF11 against asthma. Conclusion: The results provide supporting evidence for genetic variants in PHF11 and DPP10 genes underlying asthma susceptibility and asthma-related quantitative traits in a Han Chinese population.

Journal article

Yates L, McMurray F, Zhang Y, Greenfield Y, Moffatt M, Cookson W, Dean C 2009et al., 2009, ENU mutagenesis as a tool for understanding lung development and disease Biochemical Society Transactions 37: 838–842.

Journal article

Himes BE, Hunninghake GM, Baurley JW, Rafaels NM, Sleiman P, Strachan DP, Wilk JB, Willis-Owen SAG, Klanderman B, Lasky-Su J, Lazarus R, Murphy AJ, Soto-Quiros ME, Avila L, Beaty T, Mathias RA, Ruczinski I, Barnes KC, Celedon JC, Cookson WOC, Gauderman WJ, Gilliland FD, Hakonarson H, Lange C, Moffatt MF, O'Connor GT, Raby BA, Silverman EK, Weiss STet al., 2009, Genome-wide Association Analysis Identifies <i>PDE4D</i> as an Asthma-Susceptibility Gene, AMERICAN JOURNAL OF HUMAN GENETICS, Vol: 84, Pages: 581-593, ISSN: 0002-9297

Journal article

Cookson W, Liang L, Abecasis G, Moffatt M, Lathrop Met al., 2009, Mapping complex disease traits with global gene expression, NATURE REVIEWS GENETICS, Vol: 10, Pages: 184-194, ISSN: 1471-0056

Journal article

Willis-Owen SA, Moffatt MF, Cookson WO, 2009, The genetics of asthma and atopic dermatitis., Allergy and Allergic Diseases., Oxford, Publisher: Blackwell Publishing

Book chapter

Willis-Owen SAG, Cookson WO, Moffatt MF, 2009, Genome-Wide Association Studies in the Genetics of Asthma, CURRENT ALLERGY AND ASTHMA REPORTS, Vol: 9, Pages: 3-9, ISSN: 1529-7322

Journal article

Gao J, Willis-Owen SA, Moffatt M, Cookson W, Zhang Yet al., 2009, Polymorphisms of <i>PHF11</i> and <i>DPP10</i> Are Associated with Asthma and Related Traits in a Chinese Population., AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 179, ISSN: 1073-449X

Journal article

Rodriguez E, Gieger C, Baurecht H, Mempel M, Wagenpfeil S, Ollert M, Ring J, Behrendt H, Heinrich J, Novak N, Bieber T, Prokisch H, Depner M, von Mutius E, Liang L, Moffatt M, Cookson W, Kabesch M, Wichmann H, Illig T, Weidinger Set al., 2009, Genome-wide scan on total serum IgE levels identifies <i>FC</i>E<i>R1a</i> as novel susceptibility locus, 28th Congress of the European-Academy-of-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: 50-50, ISSN: 0105-4538

Conference paper

Genuneit J, Cantelmo JL, Weinmayr G, Weiland SK, Cookson WO, Strachan D, Moffatt MFet al., 2009, A Multi-Centre Study of Candidate Genes for Asthma and Allergy. The <i>International Study of Asthma and Allergies in Childhood Phase 2</i>., AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 179, ISSN: 1073-449X

Journal article

Moffatt MF, 2008, Genes in asthma: new genes and new ways, CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 8, Pages: 411-417, ISSN: 1528-4050

Journal article

Weidinger S, Gieger C, Rodriguez E, Baurecht H, Mempel M, Klopp N, Gohlke H, Wagenpfeil S, Ollert M, Ring J, Behrendt H, Heinrich J, Novak N, Bieber T, Kraemer U, Berdel D, von Berg A, Bauer CP, Herbarth O, Koletzko S, Prokisch H, Mehta D, Meitinger T, Depner M, von Mutius E, Liang L, Moffatt M, Cookson W, Kabesch M, Wichmann H-E, Illig Tet al., 2008, Genome-Wide Scan on Total Serum IgE Levels Identifies <i>FCER1A</i> as Novel Susceptibility Locus, PLOS GENETICS, Vol: 4, ISSN: 1553-7404

Journal article

Moffatt MF, Cookson WOCM, 2008, Asthma and chitinases, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 358, Pages: 1725-1726, ISSN: 0028-4793

Journal article

Dixon AL, Liang L, Moffatt MF, Chen W, Heath S, Wong KCC, Taylor J, Burnett E, Gut I, Farrall M, Lathrop GM, Abecasis GR, Cookson WOCet al., 2007, A genome-wide association study of global gene expression, NATURE GENETICS, Vol: 39, Pages: 1202-1207, ISSN: 1061-4036

Journal article

Moffatt MF, Kabesch M, Liang L, Dixon AL, Strachan D, Heath S, Depner M, von Berg A, Bufe A, Rietschel E, Heinzmann A, Simma B, Frischer T, Willis-Owen SAG, Wong KCC, Illig T, Vogelberg C, Weiland SK, von Mutius E, Abecasis GR, Farrall M, Gut IG, Lathrop GM, Cookson WOCet al., 2007, Genetic variants regulating <i>ORMDL3</i> expression contribute to the risk of childhood asthma, NATURE, Vol: 448, Pages: 470-U5, ISSN: 0028-0836

Journal article

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