Imperial College London
Portrait Picture

PROFESSOR MIRIAM F. MOFFATT

Faculty of Medicine, National Heart & Lung Institute

Consul for the Faculty of Medicine, Professor
 
 
 
//

Contact

 

+44 (0)20 7594 2942m.moffatt

 
 
//

Location

 

400Guy Scadding BuildingRoyal Brompton Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Groves:2020:10.1128/mBio.03236-19,
author = {Groves, HT and Higham, SL and Moffatt, MF and Cox, MJ and Tregoning, JS},
doi = {10.1128/mBio.03236-19},
journal = {mBio},
title = {Respiratory viral infection alters the gut microbiota by inducing inappetence},
url = {http://dx.doi.org/10.1128/mBio.03236-19},
volume = {11},
year = {2020}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Respiratory viral infections are extremely common, but their impacts on the composition and function of the gut microbiota are poorly understood. We previously observed a significant change in the gut microbiota after viral lung infection. Here, we show that weight loss during respiratory syncytial virus (RSV) or influenza virus infection was due to decreased food consumption, and that the fasting of mice altered gut microbiota composition independently of infection. While the acute phase tumor necrosis factor alpha (TNF-α) response drove early weight loss and inappetence during RSV infection, this was not sufficient to induce changes in the gut microbiota. However, the depletion of CD8+ cells increased food intake and prevented weight loss, resulting in a reversal of the gut microbiota changes normally observed during RSV infection. Viral infection also led to changes in the fecal gut metabolome, with a significant shift in lipid metabolism. Sphingolipids, polyunsaturated fatty acids (PUFAs), and the short-chain fatty acid (SCFA) valerate were all increased in abundance in the fecal metabolome following RSV infection. Whether this and the impact of infection-induced anorexia on the gut microbiota are part of a protective anti-inflammatory response during respiratory viral infections remains to be determined.
AU  - Groves,HT
AU  - Higham,SL
AU  - Moffatt,MF
AU  - Cox,MJ
AU  - Tregoning,JS
DO  - 10.1128/mBio.03236-19
PY  - 2020///
SN  - 2150-7511
TI  - Respiratory viral infection alters the gut microbiota by inducing inappetence
T2  - mBio
UR  - http://dx.doi.org/10.1128/mBio.03236-19
UR  - http://hdl.handle.net/10044/1/76874
VL  - 11
ER  -
Download