Imperial College London

ProfessorMaryMorrell

Faculty of MedicineNational Heart & Lung Institute

Professor of Sleep & Respiratory Physiology
 
 
 
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Contact

 

+44 (0)20 7352 8121 ext 4023m.morrell

 
 
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Location

 

Sleep LabSouth BlockRoyal Brompton Campus

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Summary

 

Publications

Publication Type
Year
to

102 results found

Alqurashi Y, Moss J, Nakamura T, Goverdovsky V, Polkey M, Mandic D, Morrell MJet al., 2017, The Efficacy Of In-Ear Electroencephalography (eeg) To Monitor Sleep Latency And The Impact Of Sleep Deprivation, International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X

CONFERENCE PAPER

Atalla A, Carlisle TW, Simonds AK, Cowie MR, Morrell MJet al., 2017, Sleepiness and activity in heart failure patients with reduced ejection fraction and central sleep-disordered breathing, SLEEP MEDICINE, Vol: 34, Pages: 217-223, ISSN: 1389-9457

JOURNAL ARTICLE

Ayas NT, Drager LF, Morrell MJ, Polotsky VYet al., 2017, Update in Sleep-disordered Breathing 2016, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 195, Pages: 1561-1566, ISSN: 1073-449X

JOURNAL ARTICLE

Brill A-K, Moghal M, Morrell MJ, Simonds AKet al., 2017, Randomized crossover trial of a pressure sensing visual feedback system to improve mask fitting in noninvasive ventilation., Respirology, Vol: 22, Pages: 1343-1349

BACKGROUND AND OBJECTIVE: A good mask fit, avoiding air leaks and pressure effects on the skin are key elements for a successful noninvasive ventilation (NIV). However, delivering practical training for NIV is challenging, and it takes time to build experience and competency. This study investigated whether a pressure sensing system with real-time visual feedback improved mask fitting. METHODS: During an NIV training session, 30 healthcare professionals (14 trained in mask fitting and 16 untrained) performed two mask fittings on the same healthy volunteer in a randomized order: one using standard mask-fitting procedures and one with additional visual feedback on mask pressure on the nasal bridge. Participants were required to achieve a mask fit with low mask pressure and minimal air leak (<10 L/min). Pressure exerted on the nasal bridge, perceived comfort of mask fit and staff- confidence were measured. RESULTS: Compared with standard mask fitting, a lower pressure was exerted on the nasal bridge using the feedback system (71.1 ± 17.6 mm Hg vs 63.2 ± 14.6 mm Hg, P < 0.001). Both untrained and trained healthcare professionals were able to reduce the pressure on the nasal bridge (74.5 ± 21.2 mm Hg vs 66.1 ± 17.4 mm Hg, P = 0.023 and 67 ± 12.1 mm Hg vs 60 ± 10.6 mm Hg, P = 0.002, respectively) using the feedback system and self-rated confidence increased in the untrained group. CONCLUSION: Real-time visual feedback using pressure sensing technology supported healthcare professionals during mask-fitting training, resulted in a lower pressure on the skin and better mask fit for the volunteer, with increased staff confidence.

JOURNAL ARTICLE

Carlisle T, Ward NR, Atalla A, Cowie MR, Simonds AK, Morrell MJet al., 2017, Investigation of the link between fluid shift and airway collapsibility as a mechanism for obstructive sleep apnea in congestive heart failure, PHYSIOLOGICAL REPORTS, Vol: 5, ISSN: 2051-817X

JOURNAL ARTICLE

Eastwood PR, Morrell MJ, Malhotra A, 2017, Update in respiratory sleep disorders: Prologue to a modern review series, RESPIROLOGY, Vol: 22, Pages: 17-18, ISSN: 1323-7799

JOURNAL ARTICLE

Goverdovsky V, von Rosenberg W, Nakamura T, Looney D, Sharp DJ, Papavassiliou C, Morrell MJ, Mandic DPet al., 2017, Hearables: Multimodal physiological in-ear sensing., Sci Rep, Vol: 7

Future health systems require the means to assess and track the neural and physiological function of a user over long periods of time, and in the community. Human body responses are manifested through multiple, interacting modalities - the mechanical, electrical and chemical; yet, current physiological monitors (e.g. actigraphy, heart rate) largely lack in cross-modal ability, are inconvenient and/or stigmatizing. We address these challenges through an inconspicuous earpiece, which benefits from the relatively stable position of the ear canal with respect to vital organs. Equipped with miniature multimodal sensors, it robustly measures the brain, cardiac and respiratory functions. Comprehensive experiments validate each modality within the proposed earpiece, while its potential in wearable health monitoring is illustrated through case studies spanning these three functions. We further demonstrate how combining data from multiple sensors within such an integrated wearable device improves both the accuracy of measurements and the ability to deal with artifacts in real-world scenarios.

JOURNAL ARTICLE

Khazaie H, Veronese M, Noori K, Emamian F, Zarei M, Ashkan K, Leschziner GD, Eickhoff CR, Eickhoff SB, Morrell MJ, Osorio RS, Spiegelhalder K, Tahmasian M, Rosenzweig Iet al., 2017, Functional reorganization in obstructive sleep apnoea and insomnia: A systematic review of the resting-state fMRI, NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, Vol: 77, Pages: 219-231, ISSN: 0149-7634

JOURNAL ARTICLE

Nakamura T, Goverdovsky V, Morrell MJ, Mandic DPet al., 2017, Automatic Sleep Monitoring Using Ear-EEG, IEEE JOURNAL OF TRANSLATIONAL ENGINEERING IN HEALTH AND MEDICINE-JTEHM, Vol: 5, ISSN: 2168-2372

JOURNAL ARTICLE

Patel S, Kon SSC, Nolan CM, Barker RE, Simonds AK, Morrell MJ, Man WD-Cet al., 2017, The Epworth Sleepiness Scale: Minimum Clinically Important Difference in Obstructive Sleep Apnea., Am J Respir Crit Care Med

JOURNAL ARTICLE

Patrick Y, Lee A, Raha O, Pillai K, Gupta S, Sethi S, Mukeshimana F, Gerard L, Moghal MU, Saleh SN, Smith SF, Morrell MJ, Moss Jet al., 2017, Effects of sleep deprivation on cognitive and physical performance in university students, SLEEP AND BIOLOGICAL RHYTHMS, Vol: 15, Pages: 217-225, ISSN: 1446-9235

JOURNAL ARTICLE

Rosenzweig I, Morrell MJ, 2017, Hypotrophy versus Hypertrophy: It's Not Black or White with Gray Matter, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 195, Pages: 1416-1418, ISSN: 1073-449X

JOURNAL ARTICLE

Emamian F, Khazaie H, Tahmasian M, Leschziner GD, Morrell MJ, Hsiung G-YR, Rosenzweig N, Sepehry AAet al., 2016, The Association Between Obstructive Sleep Apnea and Alzheimer's Disease: A Meta-Analysis Perspective, FRONTIERS IN AGING NEUROSCIENCE, Vol: 8, ISSN: 1663-4365

JOURNAL ARTICLE

Looney D, Goverdovsky V, Rosenzweig I, Morrell MJ, Mandic DPet al., 2016, Wearable In-Ear Encephalography Sensor for Monitoring Sleep Preliminary Observations from Nap Studies, ANNALS OF THE AMERICAN THORACIC SOCIETY, Vol: 13, Pages: 2229-2233, ISSN: 1546-3222

JOURNAL ARTICLE

McMillan A, Morrell MJ, 2016, Sleep disordered breathing at the extremes of age: the elderly, BREATHE, Vol: 12, Pages: 51-60, ISSN: 1810-6838

JOURNAL ARTICLE

Morrell MJ, McMillan A, 2016, Does Age Matter? The Relationship between Sleep-disordered Breathing and Incident Atrial Fibrillation in Older Men, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 193, Pages: 712-714, ISSN: 1073-449X

JOURNAL ARTICLE

Rosenzweig I, Glasser M, Crum WR, Kempton MJ, Milosevic M, McMillan A, Leschziner GD, Kumari V, Goadsby P, Simonds AK, Williams SCR, Morrell MJet al., 2016, Changes in Neurocognitive Architecture in Patients with Obstructive Sleep Apnea Treated with Continuous Positive Airway Pressure, EBIOMEDICINE, Vol: 7, Pages: 221-229, ISSN: 2352-3964

JOURNAL ARTICLE

Tahmasian M, Rosenzweig I, Eickhoff SB, Sepehry AA, Laird AR, Fox PT, Morrell MJ, Khazaie H, Eickhoff CRet al., 2016, Structural and functional neural adaptations in obstructive sleep apnea: An activation likelihood estimation meta-analysis, NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, Vol: 65, Pages: 142-156, ISSN: 0149-7634

JOURNAL ARTICLE

McMillan A, Bratton DJ, Faria R, Laskawiec-Szkonter M, Griffin S, Davies RJ, Nunn AJ, Stradling JR, Riha RL, Morrell MJet al., 2015, A multicentre randomised controlled trial and economic evaluation of continuous positive airway pressure for the treatment of obstructive sleep apnoea syndrome in older people: PREDICT, HEALTH TECHNOLOGY ASSESSMENT, Vol: 19, Pages: 1-+, ISSN: 1366-5278

JOURNAL ARTICLE

Morrell MJ, 2015, One hundred years of pulmonary function testing: a perspective on 'The diffusion of gases through the lungs of man' by Marie Krogh, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 593, Pages: 351-352, ISSN: 0022-3751

JOURNAL ARTICLE

Rosenzweig I, Glasser M, Polsek D, Leschziner GD, Williams SC, Morrell MJet al., 2015, Sleep apnoea and the brain: a complex relationship., Lancet Respiratory Medicine, Vol: 3, Pages: 404-414, ISSN: 2213-2619

Intermittent hypoxia, reoxygenation, and hypercapnia or hypocapnia occur in both adults and children during untreated apnoea and hypopnoea, along with changes in cerebral blood flow and sleep fragmentation. These effects can result in cognitive deficits with functional effects on work and school efficiency. The assessment of how obstructive sleep apnoea affects cognition depends on the specificity and sensitivity of the tests, which are rarely developed specifically for obstructive sleep apnoea. In this Review, we discuss both the neural adaptive and maladaptive processes in response to hypoxaemia. The net result on cognitive and emotional performance depends on the stage of this dynamic process, effects on other body systems, cognitive reserve, and idiosyncratic susceptibility. We also explore the contribution of fragmented sleep, and the disruption of sleep structure, with focus on the effect at different times in the development of disease. This Review will address the gap in the underlying pathophysiology of new clinical and translational findings, and argue their contribution to the inherent complexity of the association between obstructive sleep apnoea and the brain.

JOURNAL ARTICLE

Carlisle T, Carthy ER, Glasser M, Drivas P, McMillan A, Cowie MR, Simonds AK, Morrell MJet al., 2014, Upper airway factors that protect against obstructive sleep apnoea in healthy older males, EUROPEAN RESPIRATORY JOURNAL, Vol: 44, Pages: 685-693, ISSN: 0903-1936

JOURNAL ARTICLE

Kelly JL, Jaye J, Pickersgill RE, Chatwin M, Morrell MJ, Simonds AKet al., 2014, Randomized trial of 'intelligent' autotitrating ventilation versus standard pressure support non-invasive ventilation: Impact on adherence and physiological outcomes, RESPIROLOGY, Vol: 19, Pages: 596-603, ISSN: 1323-7799

JOURNAL ARTICLE

McMillan A, Bratton DJ, Faria R, Laskawiec-Szkonter M, Griffin S, Davies RJ, Nunn AJ, Stradling JR, Riha RL, Morrell MJet al., 2014, Continuous positive airway pressure in older people with obstructive sleep apnoea syndrome (PREDICT): a 12-month, multicentre, randomised trial, LANCET RESPIRATORY MEDICINE, Vol: 2, Pages: 804-812, ISSN: 2213-2600

JOURNAL ARTICLE

McMillan A, Bratton DJ, Faria R, Laskawiec-Szkonter M, Griffin S, Nunn AJ, Stradling JR, Riha RL, Morrell MJet al., 2014, Sleep apnoea in the elderly - authors' reply., Lancet Respir Med, Vol: 2, Pages: e21-e22

JOURNAL ARTICLE

Quinnell TG, Bennett M, Jordan J, Clutterbuck-James AL, Davies MG, Smith IE, Oscroft N, Pittman MA, Cameron M, Chadwick R, Morrell MJ, Glover MJ, Fox-Rushby JA, Sharples LDet al., 2014, A crossover randomised controlled trial of oral mandibular advancement devices for obstructive sleep apnoea-hypopnoea (TOMADO), THORAX, Vol: 69, Pages: 938-945, ISSN: 0040-6376

JOURNAL ARTICLE

Rosenzweig I, Williams SCR, Morrell MJ, 2014, The impact of sleep and hypoxia on the brain: potential mechanisms for the effects of obstructive sleep apnea, CURRENT OPINION IN PULMONARY MEDICINE, Vol: 20, Pages: 565-571, ISSN: 1070-5287

JOURNAL ARTICLE

Shaikh ZF, Kelly JL, Shrikrishna D, de Villa M, Mullen MJ, Hopkinson NS, Morrell MJ, Polkey MIet al., 2014, Patent Foramen Ovale Is Not Associated with Hypoxemia in Severe Chronic Obstructive Pulmonary Disease and Does Not Impair Exercise Performance, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 189, Pages: 540-547, ISSN: 1073-449X

JOURNAL ARTICLE

Glasser M, Rosenzweig I, McMillan A, Drivas P, Satkunam K, Man WDC, Simonds AK, Morrell MJet al., 2013, Neuroanatomical Correlates Of Cognitive Dysfunction In Obstructive Sleep Apnoea: An Ongoing Study, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 187, ISSN: 1073-449X

JOURNAL ARTICLE

Rosenzweig I, Kempton MJ, Crum WR, Glasser M, Milosevic M, Beniczky S, Corfield DR, Williams SC, Morrell MJet al., 2013, Hippocampal Hypertrophy and Sleep Apnea: A Role for the Ischemic Preconditioning?, PLOS ONE, Vol: 8, ISSN: 1932-6203

JOURNAL ARTICLE

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