Imperial College London
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ProfessorMaryMorrell

Faculty of Medicine, National Heart & Lung Institute

Professor of Sleep & Respiratory Physiology
 
 
 
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m.morrell

 
 
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Location

 

Room 103ASir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{McMillan:2014:10.1016/S2213-2600(14)70172-9,
author = {McMillan, A and Bratton, DJ and Faria, R and Laskawiec-Szkonter, M and Griffin, S and Davies, RJ and Nunn, AJ and Stradling, JR and Riha, RL and Morrell, MJ},
doi = {10.1016/S2213-2600(14)70172-9},
journal = {The Lancet Respiratory Medicine},
pages = {804--812},
title = {Continuous positive airway pressure in older people with obstructive sleep apnoea syndrome (PREDICT): a 12-month, multicentre, randomised trial},
url = {http://dx.doi.org/10.1016/S2213-2600(14)70172-9},
volume = {2},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundThe therapeutic and economic benefits of continuous positive airway pressure (CPAP) for moderate to severe obstructive sleep apnoea (OSA) syndrome have been established in middle-aged people; however, the benefits in older people are unknown. This trial was designed to address this evidence gap.MethodsThis 12-month, multicentre, randomised trial enrolled patients across 14 National Health Service sleep centres in the UK. Consecutive patients aged 65 years or older with newly diagnosed OSA syndrome were eligible to join the trial. Patients were randomly assigned (1:1) into parallel groups to receive either CPAP with best supportive care (BSC) or BSC alone for 12 months. Randomisation was done by the Medical Research Council Clinical Trials Unit with computer-generated randomisation. The main investigator at each centre was masked to the trial randomisation. Coprimary endpoints were Epworth sleepiness score (ESS) at 3 months and cost-effectiveness over the 12-month trial period. Secondary outcomes were subjective sleepiness at 12 months, plus objective sleepiness, quality of life, mood, functionality, nocturia, mobility, accidents, cognitive function, and cardiovascular risk factors and events at 3 months and 12 months. The analysis was by intention to treat. This study is registered as an International Standard Randomised Controlled Trial, number ISRCTN90464927.FindingsBetween Feb 24, 2010, and May 30, 2012, 278 patients were randomly assigned to the trial, of whom 231 (83%) completed the trial. 140 patients were allocated to and received CPAP plus BSC and 138 were allocated to and received BSC only. CPAP reduced ESS by 2·1 points (95% CI −3·0 to −1·3; p<0·0001) at 3 months for 124 (89%) of 140 patients compared with 124 (90%) of 138 patients given BSC, and by 2·0 points (−2·8 to −1·2; p<0·0001) at 12 months for 116 patients compared with 122 patients given BSC. The effect
AU  - McMillan,A
AU  - Bratton,DJ
AU  - Faria,R
AU  - Laskawiec-Szkonter,M
AU  - Griffin,S
AU  - Davies,RJ
AU  - Nunn,AJ
AU  - Stradling,JR
AU  - Riha,RL
AU  - Morrell,MJ
DO  - 10.1016/S2213-2600(14)70172-9
EP  - 812
PY  - 2014///
SN  - 2213-2600
SP  - 804
TI  - Continuous positive airway pressure in older people with obstructive sleep apnoea syndrome (PREDICT): a 12-month, multicentre, randomised trial
T2  - The Lancet Respiratory Medicine
UR  - http://dx.doi.org/10.1016/S2213-2600(14)70172-9
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000342692100021&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
VL  - 2
ER  -
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