Imperial College London
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ProfessorMaryMorrell

Faculty of Medicine, National Heart & Lung Institute

Professor of Sleep & Respiratory Physiology
 
 
 
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m.morrell

 
 
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Location

 

Room 103ASir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Rosenzweig:2016:10.1016/j.ebiom.2016.03.020,
author = {Rosenzweig, I and Glasser, M and Crum, WR and Kempton, MJ and Milosevic, M and McMillan, A and Leschziner, GD and Kumari, V and Goadsby, P and Simonds, AK and Williams, SC and Morrell, MJ},
doi = {10.1016/j.ebiom.2016.03.020},
journal = {EBioMedicine},
pages = {221--229},
title = {Changes in Neurocognitive Architecture in Patients with Obstructive Sleep Apnea Treated with Continuous Positive Airway Pressure.},
url = {http://dx.doi.org/10.1016/j.ebiom.2016.03.020},
volume = {7},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Obstructive sleep apnea (OSA) is a chronic, multisystem disorder that has a bidirectional relationship with several major neurological disorders, including Alzheimer's dementia. Treatment with Continuous Positive Airway Pressure (CPAP) offers some protection from the effects of OSA, although it is still unclear which populations should be targeted, for how long, and what the effects of treatment are on different organ systems. We investigated whether cognitive improvements can be achieved as early as one month into CPAP treatment in patients with OSA. METHODS: 55 patients (mean (SD) age: 47.6 (11.1) years) with newly diagnosed moderate-severe OSA (Oxygen Desaturation Index: 36.6 (25.2) events/hour; Epworth sleepiness score (ESS): 12.8 (4.9)) and 35 matched healthy volunteers were studied. All participants underwent neurocognitive testing, neuroimaging and polysomnography. Patients were randomized into parallel groups: CPAP with best supportive care (BSC), or BSC alone for one month, after which they were re-tested. FINDINGS: One month of CPAP with BSC resulted in a hypertrophic trend in the right thalamus [mean difference (%): 4.04, 95% CI: 1.47 to 6.61], which was absent in the BSC group [-2.29, 95% CI: -4.34 to -0.24]. Significant improvement was also recorded in ESS, in the CPAP plus BSC group, following treatment [mean difference (%): -27.97, 95% CI: -36.75 to -19.19 vs 2.46, 95% CI: -5.23 to 10.15; P=0.012], correlated to neuroplastic changes in brainstem (r=-0.37; P=0.05), and improvements in delayed logical memory scores [57.20, 95% CI: 42.94 to 71.46 vs 23.41, 95% CI: 17.17 to 29.65; P=0.037]. INTERPRETATION: One month of CPAP treatment can lead to adaptive alterations in the neurocognitive architecture that underlies the reduced sleepiness, and improved verbal episodic memory in patients with OSA. We propose that partial neural recovery occurs during short periods of treatment with CPAP.
AU  - Rosenzweig,I
AU  - Glasser,M
AU  - Crum,WR
AU  - Kempton,MJ
AU  - Milosevic,M
AU  - McMillan,A
AU  - Leschziner,GD
AU  - Kumari,V
AU  - Goadsby,P
AU  - Simonds,AK
AU  - Williams,SC
AU  - Morrell,MJ
DO  - 10.1016/j.ebiom.2016.03.020
EP  - 229
PY  - 2016///
SN  - 2352-3964
SP  - 221
TI  - Changes in Neurocognitive Architecture in Patients with Obstructive Sleep Apnea Treated with Continuous Positive Airway Pressure.
T2  - EBioMedicine
UR  - http://dx.doi.org/10.1016/j.ebiom.2016.03.020
UR  - http://hdl.handle.net/10044/1/34219
VL  - 7
ER  -
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