Imperial College London


Faculty of Natural SciencesDepartment of Life Sciences

Reader in Immunology







605Sir Alexander Fleming BuildingSouth Kensington Campus





Dr Masahiro Ono is an immunologist and expert in T-cell regulation. His research focuses on mechanisms of T cell activation and regulation in autoimmunity, infections, and cancer. He is the pioneer of the Timer-of-Cell-Kinetics-and-Activity (Tocky, とき), which analyses temporal changes of T-cell activities in vivo using Fluorescent Timer protein.

Dr Ono did his undergraduate in Faculty of Medicine, Kyoto University (1993-1999, MD) and later was trained in dermatology. He did his PhD in 2002 - 2006 in the study of regulatory T cells (Tregs) and the transcription factors Foxp3 and Runx1, starting his immunology career. In 2009, he obtained a HFSP Fellowship, and joined University College London (UCL), when he extended his research to immunological genomics. In 2012, he was awarded a BBSRC David Phillips Fellowship, and established his lab in UCL. He joined Imperial in 2015 and was appointed as a Senior Lecturer in 2018. He was promoted to a Reader in Immunology in 2020.

The lab website

CRUK Convergence Science Centre



Tan BJ, Sugata K, Reda O, et al., 2021, HTLV-1 infection promotes excessive T cell activation and transformation into adult T cell leukemia/lymphoma., J Clin Invest, Vol:131

Bortoluzzi S, Dashtsoodol N, Engleitner T, et al., 2021, Brief homogeneous TCR signals instruct common iNKT progenitors whose effector diversification is characterized by subsequent cytokine signaling, Immunity, Vol:54, ISSN:1074-7613, Pages:2497-+

Abe H, Tanada Y, Omiya S, et al., 2021, NF-kappa B activation in cardiac fibroblasts results in the recruitment of inflammatory Ly6C(hi) monocytes in pressure-overloaded hearts, Science Signaling, Vol:14, ISSN:1945-0877

Ono M, 2021, Restoring control over autoimmunity by inducing Foxp3, Nature Immunology, Vol:22, ISSN:1529-2908, Pages:1080-1082

Lau C-I, Rowell J, Yanez DC, et al., 2021, The pioneer transcription factors Foxa1 and Foxa2 regulate alternative RNA splicing during thymocyte positive selection, Development, Vol:148, ISSN:0950-1991

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