Dr Masahiro Ono was originally trained as a dermatologist, and later specialised in molecular and systems immunology. He obtained his PhD in 2006 on autoimmunity and regulatory T cells, and thereafter, worked on the molecular mechanism of the transcription factor Foxp3, revealing the interaction of Foxp3 and the transcription factor Runx1 and their transcriptional mechanisms. In 2009, he obtained a Human Frontier Science Program Long-Term Fellowship, and joined University College London (UCL). Thus he extended his expertise to genomics and systems analysis, establishing a new multidimensional framework for visualising transcriptomic data and unravelling complex processes in T cell differentiation. In 2012, he was awarded a prestigious Biotechnology and Biological Sciences Research Council (BBSRC) David Phillips Fellowship, thereby established his lab in UCL. In 2015, he was appointed to a proleptic Senior Lecturer in the Department of Life Sciences, Imperial. He is conducting multidisciplinary projects on the transcriptional programme of T cell memory and immune regulation.
Bending D, Ono M, 2017, Interplay between the skin barrier and immune cells in patients with atopic dermatitis unraveled by means of mathematical modeling, Journal of Allergy and Clinical Immunology, Vol:139, ISSN:0091-6749, Pages:1790-1792
et al., 2017, The impact of environmental enrichment on the murine inflammatory immune response, Jci Insight, Vol:2, ISSN:2379-3708
Bending D, Ono M, 2017, FoxP3 partners up, Nature Immunology, Vol:18, ISSN:1529-2908, Pages:1181-1183
et al., 2016, Impact of Enriched Environment on Murine T Cell Differentiation and Gene Expression Profile, Frontiers in Immunology, Vol:7, ISSN:1664-3224
Ono M, Bending D, Martin PP, 2017, Revealing the mechanism of regulatory T-cell generation in vivo by novel Fluorescent Timer reporter, Annual Meeting of the American-Association-of-Immunologists (AAI), AMER ASSOC IMMUNOLOGISTS, ISSN:0022-1767