Imperial College London
Alternate

ProfessorMalcolmParker

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Emeritus Professor of Molecular Endocrinology
 
 
 
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Contact

 

+44 (0)20 7594 2177m.parker Website

 
 
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Assistant

 

Miss Kiran Dosanjh +44 (0)20 7594 2176

 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Fritah:2010:10.1152/ajpendo.00243.2010,
author = {Fritah, A and Christian, M and Parker, MG},
doi = {10.1152/ajpendo.00243.2010},
journal = {Am J Physiol Endocrinol Metab},
pages = {E335--E340},
title = {The metabolic coregulator RIP140: an update},
url = {http://dx.doi.org/10.1152/ajpendo.00243.2010},
volume = {299},
year = {2010}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - RIP140 is a transcriptional coregulator highly expressed in metabolic tissues where it has important and diverse actions. RIP140-null mice show that it plays a crucial role in the control of lipid metabolism in adipose tissue, skeletal muscle, and the liver and is essential for female fertility. RIP140 has been shown to act as a ligand-dependent transcriptional corepressor for metabolic nuclear receptors such as estrogen-related receptors and peroxisome proliferator-activated receptors. The role of RIP140 as a corepressor has been strengthened by the characterization of RIP140-overexpressing mice, although it emerges through several studies that RIP140 can also behave as a coactivator. Nuclear localization of RIP140 is important for controlling transcription of target genes and is subject to regulation by posttranslational modifications. However, cytoplasmic RIP140 has been shown to play a role in the control of metabolism through direct regulation of glucose transport in adipocytes. In this review, we focus on recent advances highlighting the growing importance of RIP140 as a regulator of energy homeostasis.
AU  - Fritah,A
AU  - Christian,M
AU  - Parker,MG
DO  - 10.1152/ajpendo.00243.2010
EP  - 340
PY  - 2010///
SN  - 1522-1555
SP  - 335
TI  - The metabolic coregulator RIP140: an update
T2  - Am J Physiol Endocrinol Metab
UR  - http://dx.doi.org/10.1152/ajpendo.00243.2010
UR  - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20530738
VL  - 299
ER  -
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