Publications
655 results found
Jensen TJ, Ahlefelt M, Olsson M, et al., 2015, Expression Of The Irisin Precursor Fndc5 In Quadriceps Muscle Of COPD Patients Correlates With Markers Of Type I Fibers And Muscle Oxidative Phenotype, International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Hopkinson NS, Davey C, Tanner RJ, et al., 2015, Endobronchial Valves For Emphysema - Open Label Treatment Of Control Patients Following Completion Of The Believer-Hifi Study, International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Curtis KJ, O'Brien K, Tanner R, et al., 2015, Reduced Isotime Oxygen Requirement During Submaximal Exercise In Chronic Obstructive Pulmonary Disease: A Randomised Controlled Trial Of Acute Dietary Nitrate Supplementation, International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
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- Citations: 1
Hopkinson NS, Zoumot Z, Davey C, et al., 2015, Bronchoscopic Lung Volume Reduction With Endobronchial Valves Reduces Dynamic Hyperinflation: Results From The Believer-Hifi Trial, International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Mohan D, Lewis A, Patel MS, et al., 2015, Fiber Specific Signalling In Locomotor Muscle In Chronic Obstructive Pulmonary Disease (COPD), International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Mandal S, Arbane G, Murphy P, et al., 2015, Medium-term cost-effectiveness of an automated non-invasive ventilation outpatient set-up versus a standard fixed level non-invasive ventilation inpatient set-up in obese patients with chronic respiratory failure: a protocol description, BMJ OPEN, Vol: 5, ISSN: 2044-6055
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- Citations: 18
Loeckx M, Louvaris Z, Tanner RJ, et al., 2015, Compliance With A Three Month Telecoaching Program To Enhance Physical Activity In Patients With Chronic Obstructive Pulmonary Disease, International Conference of the American-Thoracic-Society (ATS), Publisher: AMER THORACIC SOC, ISSN: 1073-449X
Bloch SAA, Lee JY, Syburra T, et al., 2014, Increased expression of GDF-15 may mediate ICU-acquired weakness by down-regulating muscle microRNAs, Thorax, Vol: 70, Pages: 219-228, ISSN: 0040-6376
Rationale The molecular mechanisms underlying the muscle atrophy of intensive care unit-acquired weakness (ICUAW) are poorly understood. We hypothesised that increased circulating and muscle growth and differentiation factor-15 (GDF-15) causes atrophy in ICUAW by changing expression of key microRNAs.Objectives To investigate GDF-15 and microRNA expression in patients with ICUAW and to elucidate possible mechanisms by which they cause muscle atrophy in vivo and in vitro.Methods In an observational study, 20 patients with ICUAW and seven elective surgical patients (controls) underwent rectus femoris muscle biopsy and blood sampling. mRNA and microRNA expression of target genes were examined in muscle specimens and GDF-15 protein concentration quantified in plasma. The effects of GDF-15 on C2C12 myotubes in vitro were examined.Measurements and main results Compared with controls, GDF-15 protein was elevated in plasma (median 7239 vs 2454 pg/mL, p=0.001) and GDF-15 mRNA in the muscle (median twofold increase p=0.006) of patients with ICUAW. The expression of microRNAs involved in muscle homeostasis was significantly lower in the muscle of patients with ICUAW. GDF-15 treatment of C2C12 myotubes significantly elevated expression of muscle atrophy-related genes and down-regulated the expression of muscle microRNAs. miR-181a suppressed transforming growth factor-β (TGF-β) responses in C2C12 cells, suggesting increased sensitivity to TGF-β in ICUAW muscle. Consistent with this suggestion, nuclear phospho-small mothers against decapentaplegic (SMAD) 2/3 was increased in ICUAW muscle.Conclusions GDF-15 may increase sensitivity to TGF-β signalling by suppressing the expression of muscle microRNAs, thereby promoting muscle atrophy in ICUAW. This study identifies both GDF-15 and associated microRNA as potential therapeutic targets.
Watz H, Pitta F, Rochester CL, et al., 2014, An official European Respiratory Society statement on physical activity in COPD, EUROPEAN RESPIRATORY JOURNAL, Vol: 44, Pages: 1521-1537, ISSN: 0903-1936
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- Citations: 327
Canavan JL, Kon SSC, Nolan CM, et al., 2014, STATIC BALANCE DEFICIT IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE: PREVALENCE, CLINICAL CHARACTERISTICS AND RISK OF SIGNIFICANT FALLS, Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A103-A103, ISSN: 0040-6376
Curtis KJ, Tanner R, O'Brien K, et al., 2014, ACUTE DIETARY NITRATE SUPPLEMENTATION REDUCES THE OXYGEN COST OF SUBMAXIMAL EXERCISE IN COPD, Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A215-A215, ISSN: 0040-6376
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- Citations: 3
Bas M, Haji GS, Menzies-Gow A, et al., 2014, LARYNGEAL NARROWING IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD): A MECHANISM FOR GENERATING INTRINSIC PEEP?, Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A104-A104, ISSN: 0040-6376
Jones SE, Maddocks M, Kon SSC, et al., 2014, SARCOPENIA IN COPD: PREVALENCE, CLINICAL CORRELATES AND RESPONSE TO PULMONARY REHABILITATION, Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A104-A104, ISSN: 0040-6376
Garfield BE, Parfitt L, Harries C, et al., 2014, QUALITY OF LIFE IN IDIOPATHIC PULMONARY ARTERIAL HYPERTENSION IS ASSOCIATED WITH QUADRICEPS FUNCTION AND SIZE, Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A76-A77, ISSN: 0040-6376
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- Citations: 1
Bloch SAA, Lee JY, Syburrah T, et al., 2014, GDF-15 DOWN-REGULATION OF MUSCLE MICRORNA DRIVES INCREASED SENSITIVITY TO TGF-beta SIGNALLING; A NOVEL MECHANISM IN INTENSIVE CARE UNIT ACQUIRED WEAKNESS, Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A75-A75, ISSN: 0040-6376
Bloch SAA, Syburrah T, Rosendahl U, et al., 2014, A PARADOXICAL RISE IN RECTUS FEMORIS MYOSTATIN (GDF-8) AND GDF-15 IN RESPONSE TO NEUROMUSCULAR ELECTRICAL STIMULATION IN CRITICAL CARE, Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A74-A74, ISSN: 0040-6376
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- Citations: 1
Jolley CJ, Luo YM, Steier J, et al., 2014, NEURAL RESPIRATORY DRIVE AND SYMPTOMS LIMITING EXERCISE CAPACITY IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE, Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A29-A30, ISSN: 0040-6376
Kon SSC, Jones SE, Schofield SJ, et al., 2014, GAIT SPEED IS A PREDICTOR OF MORTALITY FOLLOWING HOSPITALISATION FOR ACUTE EXACERBATIONS OF COPD, Meeting of the British-Thoracic-Society, Publisher: BMJ PUBLISHING GROUP, Pages: A45-A45, ISSN: 0040-6376
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- Citations: 3
Lord VM, Hume VJ, Kelly JL, et al., 2014, Singing classes for chronic obstructive pulmonary disease: a randomized controlled trial (vol 12, 69, 2012), BMC PULMONARY MEDICINE, Vol: 14, ISSN: 1471-2466
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- Citations: 3
Boutou AK, Tanner RJ, Lord VM, et al., 2014, An evaluation of factors associated with completion and benefit from pulmonary rehabilitation in COPD., BMJ Open Respiratory Research, Vol: 1, Pages: e000051-e000051, ISSN: 2052-4439
BACKGROUND: Pulmonary Rehabilitation (PR) is an important treatment for patients with chronic obstructive pulmonary disease (COPD) but it is not established whether any baseline parameter can predict response or compliance. AIM: To identify whether baseline measures can predict who will complete the programme and who will achieve a clinically significant benefit from a Minimum Clinical Important Difference (MCID) in terms of exercise capacity and health-related quality of life (HRQoL). METHODS: Data were collected prospectively from patients with COPD at their baseline assessment for an outpatient PR programme in one of eight centres across London. 'Completion' was defined as attending at least 75% of the designated PR visits and return for the follow-up evaluation. The MCID for outcome measures was based on published data. RESULTS: 787 outpatients with COPD (68.1±10.5 years old; 49.6% males) were included. Patients who completed PR (n=449, 57.1%) were significantly older with less severe airflow obstruction, lower anxiety and depression scores, less dyspnoea and better HRQoL. Only baseline CAT score (OR=0.925; 95% CI 0.879 to 0.974; p=0.003) was retained in multivariate analysis. Patients with the lowest baseline walking distance were most likely to achieve the MCID for exercise capacity. No baseline variable could independently predict achievement of an MCID in HRQoL. CONCLUSIONS: Patients with better HRQoL are more likely to complete PR while worse baseline exercise performance makes the achievement of a positive MCID in exercise capacity more likely. However, no baseline parameter could predict who would benefit the most in terms of HRQoL.
Maddocks M, Shrikrishna D, Vitoriano S, et al., 2014, Skeletal muscle adiposity is associated with physical activity, exercise capacity and fibre shift in COPD, European Respiratory Journal, Vol: 44, Pages: 1188-1198, ISSN: 1399-3003
Quadriceps muscle phenotype varies widely between patients with chronic obstructive pulmonary disease (COPD) and cannot be determined without muscle biopsy. We hypothesised that measures of skeletal muscle adiposity could provide noninvasive biomarkers of muscle quality in this population.In 101 patients and 10 age-matched healthy controls, mid-thigh cross-sectional area, percentage intramuscular fat and skeletal muscle attenuation were calculated using computed tomography images and standard tissue attenuation ranges: fat -190– -30 HU; skeletal muscle -29–150 HU.Mean±sd percentage intramuscular fat was higher in the patient group (6.7±3.5% versus 4.3±1.2%, p = 0.03). Both percentage intramuscular fat and skeletal muscle attenuation were associated with physical activity level, exercise capacity and type I fibre proportion, independent of age, mid-thigh cross-sectional area and quadriceps strength. Combined with transfer factor of the lung for carbon monoxide, these variables could identify >80% of patients with fibre type shift with >65% specificity (area under the curve 0.83, 95% CI 0.72–0.95).Skeletal muscle adiposity assessed by computed tomography reflects multiple aspects of COPD related muscle dysfunction and may help to identify patients for trials of interventions targeted at specific muscle phenotypes.
Hopkinson NS, Boutou AK, Nair A, et al., 2014, A Combined Pulmonary Function and Emphysema Score Prognostic Index for Staging in Chronic Obstructive Pulmonary Disease, PLOS One, Vol: 9, ISSN: 1932-6203
Introduction: Chronic Obstructive Pulmonary Disease (COPD) is characterized by high morbidity and mortality. Lung computed tomography parameters, individually or as part of a composite index, may provide more prognostic information than pulmonary function tests alone. Aim: To investigate the prognostic value of emphysema score and pulmonary artery measurements compared with lung function parameters in COPD and construct a prognostic index using a contingent staging approach. Material-Methods: Predictors of mortality were assessed in COPD outpatients whose lung computed tomography, spirometry, lung volumes and gas transfer data were collected prospectively in a clinical database. Univariate and multivariate Cox proportional hazard analysis models with bootstrap techniques were used. Results: 169 patients were included (59.8% male, 61.1 years old; Forced Expiratory Volume in 1 second % predicted: 40.5619.2). 20.1% died; mean survival was 115.4 months. Age (HR = 1.098, 95% Cl = 1.04–1.252) and emphysema score (HR = 1.034, 95% CI = 1.007–1.07) were the only independent predictors of mortality. Pulmonary artery dimensions were not associated with survival. An emphysema score of 55% was chosen as the optimal threshold and 30% and 65% as suboptimals. Where emphysema score was between 30% and 65% (intermediate risk) the optimal lung volume threshold, a functional residual capacity of 210% predicted, was applied. This contingent staging approach separated patients with an intermediate risk based on emphysema score alone into high risk (Functional Residual Capacity $210% predicted) or low risk (Functional Residual Capacity ,210% predicted). This approach was more discriminatory for survival (HR = 3.123; 95% CI = 1.094–10.412) than either individual component alone.Conclusion: Although to an extent limited by the small sample size, this preliminary study indicates that the composite Emphysema score-Functional Residual Capacity index might provide a better sep
Nouraei SM, Franco RA, Dowdall JR, et al., 2014, Physiology-Based Minimum Clinically Important Difference Thresholds in Adult Laryngotracheal Stenosis, LARYNGOSCOPE, Vol: 124, Pages: 2313-2320, ISSN: 0023-852X
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- Citations: 24
Martolini D, Tanner R, Davey C, et al., 2014, Significance of Patent Foramen Ovale in Patients with GOLD Stage II Chronic Obstructive Pulmonary Disease (COPD)., Chronic Obstr Pulm Dis, Vol: 1, Pages: 185-192, ISSN: 2372-952X
Background: Patent foramen ovale (PFO) is a common finding in adults. A PFO is associated with right to left shunting but its importance in the aetiology of hypoxia in early COPD remains uncertain, although it has not proved possible to demonstrate a role for PFOs in the aetiology of hypoxia in patients with Global Initiative for chronic Obstructive Lung Disease (GOLD) stage III/IV disease. We compared the characteristics of GOLD stage II patients with or without a PFO and assessed its impact on exercise performance. Methods: In 22 GOLD stage II COPD patients we measured exercise performance, arterial oxygen tension and lung function and used contrast transcranial Doppler ultrasonography (TCD) to assess the presence of a PFO. Patients (n=20) underwent TCD measurements during incremental cycle ergometry with respiratory pressures measured using an esophageal balloon catheter (n=13). Results:Twelve individuals (54%) had a PFO. Patients with a PFO were more hypoxic; mean(SD) partial pressure of oxygen in arterial blood (PaO2)10.2(1.1) kilopascals (kPa) vs. 11.7(0.9)kPa (p<0.01), but the presence of a PFO was not associated with reduced exercise performance either on cycle ergometry or a 6 Minute Walk Test (6MWT). A strong relationship was noted between the esophageal pressure swing (PSwingEs) and the degree of shunting observed during exercise (r=0.7; p<0.001). Conclusions:The presence of a PFO in GOLD stage II COPD patients does not appear to influence exercise performance despite increased right-to-left shunting.
Boutou A, Zoumot Z, Davey C, et al., 2014, Association between dynamic hyperinflation and emphysema distribution in COPD patients, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Boutou AK, Raste Y, Reid J, et al., 2014, Does a single <i>Pseudomonas aeruginosa</i> isolation predict COPD mortality?, EUROPEAN RESPIRATORY JOURNAL, Vol: 44, Pages: 794-797, ISSN: 0903-1936
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- Citations: 12
Mohan D, Gale NS, McEniery CM, et al., 2014, Evaluating the Role of Inflammation in Chronic Airways Disease: The ERICA Study, COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, Vol: 11, Pages: 552-559, ISSN: 1541-2555
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- Citations: 11
Kon SSC, Dilaver D, Mittal M, et al., 2014, The Clinical COPD Questionnaire: response to pulmonary rehabilitation and minimal clinically important difference, THORAX, Vol: 69, Pages: 793-798, ISSN: 0040-6376
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- Citations: 64
Haji G, Weigman C, Patel M, et al., 2014, Mitochondrial membrane potential in the airway and skeletal muscle compartments of smokers with and without COPD, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
Harvey-Dunstan TC, Radhakrishnan J, Houchen-Wolloff L, et al., 2014, Correlation between quadriceps strength and five exercise tests in subjects with chronic obstructive pulmonary disease (COPD), 22nd Annual Congress of the European-Respiratory-Society, Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936
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- Citations: 1
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