Imperial College London

Emeritus ProfessorMaryRitter

Faculty of MedicineDepartment of Medicine

Emeritus Professor of Immunology
 
 
 
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Contact

 

+44 (0)20 7492 1921m.ritter

 
 
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Location

 

31-35 Kirby StreetLondon EC1N 8TE

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Summary

 

Publications

Publication Type
Year
to

50 results found

Shrimpton RE, Butler M, Morel A-S, Eren E, Hue SS, Ritter MAet al., 2009, CD205 (DEC-205): A recognition receptor for apoptotic and necrotic self, MOLECULAR IMMUNOLOGY, Vol: 46, Pages: 1229-1239, ISSN: 0161-5890

JOURNAL ARTICLE

Butler M, Morel A-S, Jordan WJ, Eren E, Hue S, Shrimpton RE, Ritter MAet al., 2007, Altered expression and endocytic function of CD205 in human dendritic cells, and detection of a CD205-DCL-1 fusion protein upon dendritic cell maturation, IMMUNOLOGY, Vol: 120, Pages: 362-371, ISSN: 0019-2805

JOURNAL ARTICLE

Tan PH, Yates JB, Xue SA, Chan CB, Jordan WJ, Harper JE, Watson MP, Dong R, Ritter MA, Lechler RI, Lombardi G, George AJTet al., 2005, Creation of tolerogenic human dendritic cells via intracellular CTLA4: a novel strategy with potential in clinical immunosuppression, BLOOD, Vol: 106, Pages: 2936-2943, ISSN: 0006-4971

JOURNAL ARTICLE

Tan PH, Beutelspacher SC, Xue SA, Wang YH, Mitchell P, Mcalister JC, Larkin DFP, McClure MO, Stauss HJ, Ritter MA, Lombardi G, George AJTet al., 2005, Modulation of human dendritic-cell function following transduction with viral vectors: implications for gene therapy, BLOOD, Vol: 105, Pages: 3824-3832, ISSN: 0006-4971

JOURNAL ARTICLE

Tan PH, Beutelspacher SC, Wang YH, McClure MO, Ritter MA, Lombardi G, George AJTet al., 2005, Immunolipoplexes: An efficient, non-viral alternative for transfection of human dendritic cells with potential for clinical vaccination., 6th American Transplant Congress, Publisher: BLACKWELL PUBLISHING, Pages: 367-367, ISSN: 1600-6135

CONFERENCE PAPER

Tan PH, Beutelspacher SC, Wang YH, McClure MO, Ritter MA, Lombardi G, George AJTet al., 2005, Immunolipoplexes: An efficient, nonviral alternative for transfection of human dendritic cells with potential for clinical vaccination, MOLECULAR THERAPY, Vol: 11, Pages: 790-800, ISSN: 1525-0016

JOURNAL ARTICLE

Kokkinopoulos I, Jordan WJ, Ritter MA, 2005, Toll-like receptor mRNA expression patterns in human dendritic cells and monocytes, MOLECULAR IMMUNOLOGY, Vol: 42, Pages: 957-968, ISSN: 0161-5890

JOURNAL ARTICLE

Tan PH, Herrera OB, Yates J, Harper JE, Watson MP, Chan C, Xue SA, Jordan WJ, Dong R, Stauss HJ, Ritter MA, Lechler RI, Lombardi G, George AJTet al., 2005, Creation of tolerogenic antigen presenting cells via intracellular CTLA4: a novel strategy with potential clinical utility in transplantation, Annual Meeting of the Association-of-Surgeons-of-Great-Britian-and-Ireland, Publisher: JOHN WILEY & SONS LTD, Pages: 72-72, ISSN: 0007-1323

CONFERENCE PAPER

Tan PH, Xue SA, Wang YH, Beutelspacher SC, McAlister JC, Larkin DFP, McClure MO, Stauss HJ, Ritter MA, Lombardi G, George AJTet al., 2005, Modulation of human dendritic cell function following viral vectors: implications for gene therapy in vaccination, Annual Meeting of the Association-of-Surgeons-of-Great-Britain-and-Ireland, Publisher: WILEY-BLACKWELL, Pages: 134-134, ISSN: 0007-1323

CONFERENCE PAPER

Jordan WJ, Brookes PA, Szydlo RM, Goldman JM, Lechler RI, Ritter MAet al., 2004, IL-13 production by donor T cells is prognostic of acute graft-versus-host disease following unrelated donor stem cell transplantation, BLOOD, Vol: 103, Pages: 717-724, ISSN: 0006-4971

JOURNAL ARTICLE

Scupoli MT, Vinante F, Krampera M, Vincenzi C, Nadali G, Zampieri F, Ritter MA, Eren E, Santini F, Pizzolo Get al., 2003, Thymic epithelial cells promote survival of human T-cell acute lymphoblastic leukemia blasts: the role of interleukin-7, HAEMATOLOGICA, Vol: 88, Pages: 1229-1237, ISSN: 0390-6078

JOURNAL ARTICLE

Tan PH, Yates J, Xue S, Jordan WJ, Dong R, Ritter MA, Lechler RI, Lombardi G, George AJTet al., 2003, Prevention of co-stimulation molecule expression using intracellular CTLA4: a novel strategy for induction of T cell anergy, 7th Congress of the International-Xenotransplantation-Association, Publisher: BLACKWELL MUNKSGAARD, Pages: 531-531, ISSN: 0908-665X

CONFERENCE PAPER

Blackburn CC, Manley NR, Palmer DB, Boyd RL, Anderson G, Ritter MAet al., 2002, One for all and all for one: thymic epithelial stem cells and regeneration, TRENDS IN IMMUNOLOGY, Vol: 23, Pages: 391-395, ISSN: 1471-4906

JOURNAL ARTICLE

, 2002, Human mini-antibody cytotoxic for tumor cells which express the Erb B2 receptor

PATENT

De Lorenzo C, Palmer DB, Piccoli R, Ritter MA, D'Alessio Get al., 2002, A new human antitumor immunoreagent specific for ErbB2, CLINICAL CANCER RESEARCH, Vol: 8, Pages: 1710-1719, ISSN: 1078-0432

JOURNAL ARTICLE

Solomou K, Ritter MA, Palmer DB, 2002, Somatostatin is expressed in the murine thymus and enhances thymocyte development, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 32, Pages: 1550-1559, ISSN: 0014-2980

JOURNAL ARTICLE

Jordan WJ, Ritter MA, 2002, Optimal analysis of composite cytokine responses during alloreactivity, JOURNAL OF IMMUNOLOGICAL METHODS, Vol: 260, Pages: 1-14, ISSN: 0022-1759

JOURNAL ARTICLE

Scupoli MT, Vinante F, Vincenzi C, Nadali G, Ritter MA, Eeren E, Santini F, Pizzolo Get al., 2001, Bone marrow-, but not thymus-, derived stromal cells inhibit spontaneous apoptosis and induce proliferation in blasts of T-lineage ALL., BLOOD, Vol: 98, Pages: 81A-81A, ISSN: 0006-4971

JOURNAL ARTICLE

Freysdottir J, Ritter MA, 2001, Antibodies to human thymic epithelium form part of the murine autoreactive repertoire., Dev Immunol, Vol: 8, Pages: 75-93, ISSN: 1044-6672

Monoclonal antibody (mAb) MR6 recognises a 200 kDa glycoprotein, gp200-MR6, which is expressed at high levels on the surface of human thymic cortical epithelium. In order to produce further mAbs against the gp200-MR6 molecule, mice were immunised with purified human gp200-MR6, hybridomas produced and supernatants screened for MR6-like reactivity on human thymic sections. Surprisingly this conventional hybridoma technique failed to produce stable hybridoma cells producing MR6-like antibodies. However, antibodies with specificities other than MR6-like were obtained. Three such antibodies (1B2, 3A3 and 4B3) were analysed further. Expression of 1B2-antigen, 3A3-antigen and 4B3-antigen was analysed on skin, tonsil and thymic sections, on cultured thymic epithelial cells (TEC), thymocytes and peripheral blood mononuclear cells (PBMC), and found to be expressed by both lymphocytes and epithelial cell populations. Furthermore, the antigens were also expressed on mouse thymic epithelial cells. The regulation of expression of these antigens was analysed following mitogen or cytokine stimulation of PBMC and cultured TEC, respectively. Expression on T cells was clearly affected by mitogens that mimic activation through the T cell receptor and expression on cultured TEC was affected by T cell-derived cytokines. Thus, the shared epithelial-lymphocyte molecules identified in this study may play a role in the cross-talk between the developing thymocytes and their epithelial microenvironment. The production of mAbs with specificities other than that of purified gp200-MR6 indicates that a wide range of B cells with specificity for components of the human thymic microenvironment exist in the normal mouse. These may detect epitopes that are shared with common pathogens to which the animals are exposed. Alternatively, they may be autoreactive B cells that are normally silent in the absence of T cell help. This help may be provided by T cells specific for human gp200-MR6, or nonspecifica

JOURNAL ARTICLE

Johns M, George AJT, Ritter MA, 2000, In vivo selection of sFv from phage display libraries, JOURNAL OF IMMUNOLOGICAL METHODS, Vol: 239, Pages: 137-151, ISSN: 0022-1759

JOURNAL ARTICLE

Midulla M, Verma R, Pignatelli M, Ritter MA, Courtenay-Luck NS, George AJTet al., 2000, Source of oncofetal ED-B-containing fibronectin: Implications of production by both tumor and endothelial cells, CANCER RESEARCH, Vol: 60, Pages: 164-169, ISSN: 0008-5472

JOURNAL ARTICLE

Palmer DB, Solomou A, Ritter MA, 2000, Functional analysis of the thymic microenvironment using recombinant single chain antibodies, Meeting on New Horizons for Phage Antibody Display Technology, Publisher: IOS PRESS, Pages: 69-69, ISSN: 0278-0240

CONFERENCE PAPER

Ritter MA, 2000, Polyclonal and monoclonal antibodies., Methods Mol Med, Vol: 40, Pages: 23-34, ISSN: 1543-1894

The breadth of repertoire yet beautiful specificity of the antibody response is the key to its physiological efficacy in vivo; it also underpins the attractiveness of antibodies as laboratory and clinical reagents. One aspect of the body's reaction to invasion by a microorganism is the activation and clonal expansion of antigen-reactive B lymphocytes. Once these have matured into plasma cells, each clone of cells will secrete its own unique specificity of antibody-thus, the invading pathogen will be met by a barrage of antibody molecules capable of binding to many different sites on its surface. Such a polyclonal response, whose range of specificities and affinities can shift with time, is ideal for combatting infection, and indeed for certain laboratory applications (such as secondary reagents for immunoassay); however, in many experimental and clinical situations the ability to have an unlimited supply of a single antibody that is clearly defined and of reproducible specificity and affinity is of greater value. To produce such a reagent it is necessary to isolate and culture a single clone of B lymphocytes secreting antibody of the appropriate characteristics-that is, to produce a monoclonal antibody (mAb).

JOURNAL ARTICLE

Howard JK, Lord GM, Matarese G, Vendetti S, Ghatei MA, Ritter MA, Lechler RI, Bloom SRet al., 1999, Leptin protects mice from starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob mice, JOURNAL OF CLINICAL INVESTIGATION, Vol: 104, Pages: 1051-1059, ISSN: 0021-9738

JOURNAL ARTICLE

Ritter MA, Palmer DB, 1999, The human thymic microenvironment: new approaches to functional analysis, SEMINARS IN IMMUNOLOGY, Vol: 11, Pages: 13-21, ISSN: 1044-5323

JOURNAL ARTICLE

Palmer DB, Crompton T, Marandi MB, George AJT, Ritter MAet al., 1999, Intrathymic function of the human cortical epithelial cell surface antigen gp200-MR6: single-chain antibodies to evolutionarily conserved determinants disrupt mouse thymus development, IMMUNOLOGY, Vol: 96, Pages: 236-245, ISSN: 0019-2805

JOURNAL ARTICLE

McKay PF, Imami N, Johns M, Taylor-Fishwick DA, Sedibane LM, Totty NF, Hsuan JJ, Palmer DB, George AJT, Foxwell BMJ, Ritter MAet al., 1998, The gp200-MR6 molecule which is functionally associated with the IL-4 receptor modulates B cell phenotype and is a novel member of the human macrophage mannose receptor family, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 28, Pages: 4071-4083, ISSN: 0014-2980

JOURNAL ARTICLE

Imami N, Brookes PA, Lombardi G, Hakooz B, Johns M, Goldman JM, Batchelor JR, Lechler RI, Ritter MAet al., 1998, Association between interleukin-4-producing T lymphocyte frequencies and reduced risk of graft-versus-host disease, TRANSPLANTATION, Vol: 65, Pages: 979-988, ISSN: 0041-1337

JOURNAL ARTICLE

Almarri A, El Dwick N, Al Kabi S, Sleem K, Rashed A, Ritter MA, Batchelor JRet al., 1998, Interferon-alpha therapy in HCV hepatitis: HLA phenotype and cirrhosis are independent predictors of clinical outcome, HUMAN IMMUNOLOGY, Vol: 59, Pages: 239-242, ISSN: 0198-8859

JOURNAL ARTICLE

Reza JN, Ritter MA, 1998, Positive and negative selection in the thymus and the thymic paradox., Dev Immunol, Vol: 5, Pages: 161-168, ISSN: 1044-6672

JOURNAL ARTICLE

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