Dr. Magdalena Sastre graduated in Sciences and did her PhD in Biology and Health Sciences at the University of the Balearic Islands, Spain. She trained in Neuroscience in the USA (Cornell University and New York University) and in Germany (Universities of Munich, Bonn and Frankfurt).
She is interested in the molecular mechanism by which inflammation affects neurodegenerative diseases, in particular Alzheimer’s disease.
Her scientific contributions include the study of the intracellular signalling cascade of the amyloid precursor protein and how it affects its cleavage and the formation of amyloid-β peptide. In addition, she has focused her research in the use of anti-inflammatory drugs as potential therapy for neurodegenerative diseases, particularly in the role of non-steroidal anti-inflammatory drugs (NSAIDS) and peroxisome proliferator-activated receptor-γ (PPAR-γ) agonists.
et al., In vivo Imaging of microglial activation by positron emission tomography with [11C]PBR28 in the 5XFAD model of Alzheimer’s disease, Glia, ISSN:0894-1491
Birch AM, Cheung J, 2016, Alterations in the Expression of Transcription Factors PPARγ and NFκB in the Brain of Models of Chronic Pain, Biochemistry & Pharmacology: Open Access, Vol:5
et al., 2016, The nuclear cofactor receptor interacting protein-140 (RIP140) regulates the expression of genes involved in A beta generation, Neurobiology of Aging, Vol:47, ISSN:0197-4580, Pages:180-191
et al., 2016, Seeds of neuroendocrine doubt, Nature, Vol:535, ISSN:0028-0836, Pages:E1-E2
et al., 2016, PPAR gamma-coactivator-1 alpha gene transfer reduces neuronal loss and amyloid-beta generation by reducing beta-secretase in an Alzheimer's disease model, Proceedings of the National Academy of Sciences of the United States of America, Vol:113, ISSN:0027-8424, Pages:12292-12297