Dr. Magdalena Sastre graduated in Sciences and did her PhD in Biology and Health Sciences at the University of the Balearic Islands, Spain. She trained in Neuroscience in the USA (Cornell University and New York University) and in Germany (Universities of Munich, Bonn and Frankfurt).
She is interested in the molecular mechanism by which inflammation affects neurodegenerative diseases, in particular Alzheimer’s disease.
Her scientific contributions include the study of the intracellular signalling cascade of the amyloid precursor protein and how it affects its cleavage and the formation of amyloid-β peptide. In addition, she has focused her research in the use of anti-inflammatory drugs as potential therapy for neurodegenerative diseases, particularly in the role of non-steroidal anti-inflammatory drugs (NSAIDS) and peroxisome proliferator-activated receptor-γ (PPAR-γ) agonists.
et al., In vivo Imaging of microglial activation by positron emission tomography with [11C]PBR28 in the 5XFAD model of Alzheimer’s disease, Glia, ISSN:0894-1491
et al., 2018, Imaging of Microglial Activation in Alzheimer's Disease by [11C]PBR28 PET., Methods Mol Biol, Vol:1750, Pages:323-339
et al., 2017, Microglial Activation in Traumatic Brain Injury, Frontiers in Aging Neuroscience, Vol:9, ISSN:1663-4365
et al., 2018, Boxing and the brain: disruption of the neurovascular unit in chronic traumatic encephalopathy, 119th Meeting of the British-Neuropathological-Society (BNS) / Epilepsy Neuropathology Symposium, WILEY, Pages:29-29, ISSN:0305-1846