Dr. Magdalena Sastre graduated in Sciences and did her PhD in Biology and Health Sciences at the University of the Balearic Islands, Spain. She trained in Neuroscience in the USA (Cornell University and New York University) and in Germany (Universities of Munich, Bonn and Frankfurt).
She is interested in the molecular mechanism by which inflammation affects neurodegenerative diseases, in particular Alzheimer’s disease.
Her scientific contributions include the study of the intracellular signalling cascade of the amyloid precursor protein and how it affects its cleavage and the formation of amyloid-β peptide. In addition, she has focused her research in the use of anti-inflammatory drugs as potential therapy for neurodegenerative diseases, particularly in the role of non-steroidal anti-inflammatory drugs (NSAIDS) and peroxisome proliferator-activated receptor-γ (PPAR-γ) agonists.
et al., In vivo Imaging of microglial activation by positron emission tomography with [11C]PBR28 in the 5XFAD model of Alzheimer’s disease, Glia, ISSN:0894-1491
et al., Astrocytes in mouse models of tauopathies acquire early deficits and lose neurosupportive functions, Acta Neuropathologica Communications, ISSN:2051-5960
et al., 2017, Microglial Activation in Traumatic Brain Injury, Frontiers in Aging Neuroscience, Vol:9, ISSN:1663-4365
Birch AM, Cheung J, 2016, Alterations in the Expression of Transcription Factors PPARγ and NFκB in the Brain of Models of Chronic Pain, Biochemistry & Pharmacology: Open Access, Vol:5
et al., 2016, The anti-inflammatory Annexin A1 induces the clearance and degradation of the amyloid-beta peptide, Journal of Neuroinflammation, Vol:13, ISSN:1742-2094