ProfessorMagdalenaSastre

Hajji N, Calvert C, Rtichie CW, Sastre Met al., 2013, The role of metals in Alzheimer’s disease., Editors: Dexter D, Ward R, Crichton R, Dexter, Ward, Crichton, Publisher: The royal society of Chemistry (3 Jun 2013).

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Gong B, Pan Y, Vempati P, Zhao W, Knable L, Ho L, Wang J, Sastre M, Ono K, Sauve AA, Pasinetti GMet al., 2013, Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models, NEUROBIOLOGY OF AGING, Vol: 34, Pages: 1581-1588, ISSN: 0197-4580

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• Citations: 251

Gong B, Pan Y, Vempati P, Zhao W, Knable L, Ho L, Wang J, Sastre M, Ono K, Pasinetti GMet al., 2013, Nicotinamide riboside restore cognition through an up-regulation of PGC-1a regulated BACE1 degradation and mitochondrial gene expression in Alzheimer’s mouse models, Neurobiology of Aging

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Katsouri L, Vizcaychipi MP, McArthur S, Harrison I, Suárez-Calvet M, Lleo A, Lloyd DG, Ma D, Sastre Met al., 2013, Prazosin, an α(1)-adrenoceptor antagonist, prevents memory deterioration in the APP23 transgenic mouse model of Alzheimer's disease., Neurobiology of Aging, Vol: 34, Pages: 1105-1115

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Parr C, Carzaniga R, Gentleman SM, Van Leuven F, Walter J, Sastre Met al., 2012, Glycogen Synthase Kinase 3 Inhibition Promotes Lysosomal Biogenesis and Autophagic Degradation of the Amyloid-β Precursor Protein, MOLECULAR AND CELLULAR BIOLOGY, Vol: 32, Pages: 4410-4418, ISSN: 0270-7306

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• Citations: 130

Solito E, Sastre M, 2012, Microglia function in Alzheimer's disease, Front Pharmacol., Vol: 3

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Katsouri L, Blondrath K, Sastre M, 2012, PPARγ cofactors in neurodegeneration, Iubmb Life

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Solito E, Sastre M, 2012, Microglia function in Alzheimer's disease, Frontiers in Pharmacology, Vol: 3

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Sastre M, Richardson JC, Gentleman SM, Brooks DJet al., 2011, Inflammatory Risk Factors and Pathologies Associated with Alzheimer's Disease, CURRENT ALZHEIMER RESEARCH, Vol: 8, Pages: 132-141, ISSN: 1567-2050

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• Citations: 51

Thorton C, Bright N, Sastre M, Muckett PJ, Carling Det al., 2011, AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to β-amyloid exposure, Biochemical Journal, Vol: 434, Pages: 503-512

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Katsouri L, Parr C, Bogdanovic N, Willem M, Sastre Met al., 2011, PPARγ Co-Activator-1α (PGC-1α) Reduces Amyloid-β Generation Through a PPARγ-Dependent Mechanism, JOURNAL OF ALZHEIMERS DISEASE, Vol: 25, Pages: 151-162, ISSN: 1387-2877

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• Citations: 97

Kasouri L, Parr C, Bogdanovic N, Willem M, Sastre Met al., 2011, PPARγ co-activator-1α (PGC1 α) reduces Aβ generation through a PPARγ-dependent mechanism, Journal of Alzheimer’s disease, Vol: 25, Pages: 1-12

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Sastre M, 2011, Microglia function in Alzheimer's disease, Publisher: Nova Science Publishers, Inc

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Thorton C, Bright NJ, Sastre M, Muckett PJ, Carling Det al., 2011, AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure, Biochemical Journal, Vol: 434, Pages: 503-512

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Sastre M, 2010, Troubleshooting Methods for APP processing in vitro, J. Pharmacol. Toxicol. Methods., Vol: 61, Pages: 86-91

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Sastre M, Gentleman S, 2010, NSAIDs: How they work and their prospects as therapeutics in Alzheimer’s disease., Frontiers in Ageing Neuroscience, Vol: 2

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Sastre M, Heneka M, Walter J, Klockgether Tet al., 2008, Stimulation with noradrenaline induces a reduction of β-amyloid levels in neuronal cells and in APP/PS1 transgenic mice, FUNDAMENTAL & CLINICAL PHARMACOLOGY, Vol: 22, Pages: 98-98, ISSN: 0767-3981

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• Citations: 1

Sastre M, Walter J, Gentleman SM, 2008, Interactions between APP secretases and inflammatory mediators, JOURNAL OF NEUROINFLAMMATION, Vol: 5, ISSN: 1742-2094

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• Citations: 146

Sastre M, Walter J, 2008, Secretases and inflammation, Recent Advances in the biology of secretases, key proteases in Alzheimer's disease, Publisher: Research Signpost, Pages: 151-166

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Mi W, Pawlik M, Sastre M, Jung SS, Radvinsky DS, Klein AM, Sommer J, Schmidt SD, Nixon RA, Mathews PM, Levy Eet al., 2007, Cystatin C inhibits amyloid-β deposition in Alzheimer's disease mouse models, NATURE GENETICS, Vol: 39, Pages: 1440-1442, ISSN: 1061-4036

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• Citations: 152

Lleo A, Galea E, Sastre M, 2007, Molecular targets of non-steroidal anti-inflammatory drugs in neurodegenerative diseases, CELLULAR AND MOLECULAR LIFE SCIENCES, Vol: 64, Pages: 1403-1418, ISSN: 1420-682X

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• Citations: 85

Heneka MT, Sastre M, 2007, Interactions of Neuroinflammatory and Neurodegenerative Mechanisms in Alzheimer's Disease, Glia and inflammation in neurodegenerative disease, Editors: Yenari, Giffard, Pages: 117-157, ISBN: 9781594549847

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Braak H, Sastre M, Del Tredici K, 2007, Development of alpha-synuclein immunoreactive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson's disease, Acta Neuropatologica

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Braak H, Sastre M, Bohl JRE, De Vos RAI, Del Tredici Ket al., 2007, Parkinson’s disease: Lesions in dorsal horn layer I, involvement of parasympathetic and sympathetic pre- and postganglionic neurons., Acta Neuropatologica, Vol: 113, Pages: 421-429

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Lleo A, Galea E, Sastre M, 2007, Molecular targets of NSAIDs in neurodegenerative diseases., Cel. Molec. Life Sci., Vol: 64, Pages: 1403-1418

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Grommes C, Landreth GE, Sastre M, Beck M, Feinstein DL, Jacobs AH, Schlegel U, Heneka MTet al., 2006, Inhibition of in vivo glioma growth and invasion by peroxisome proliferator-activated receptor γ agonist treatment, MOLECULAR PHARMACOLOGY, Vol: 70, Pages: 1524-1533, ISSN: 0026-895X

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• Citations: 78

Sastre M, Klockgether T, Heneka MT, 2006, Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms, INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, Vol: 24, Pages: 167-176, ISSN: 0736-5748

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• Citations: 341

Heneka MT, Ramanathan M, Jacobs AH, Dumitrescu-Ozimek L, Bilkei-Gorzo A, Debeir T, Sastre M, Galldiks N, Zimmer A, Hoehn M, Heiss WD, Klockgether T, Staufenbiel Met al., 2006, Locus Ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice, JOURNAL OF NEUROSCIENCE, Vol: 26, Pages: 1343-1354, ISSN: 0270-6474

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• Citations: 242

Sastre M, Dewachter I, Rossner S, Bogdanovic N, Rosen E, Borghgraef P, Evert BO, Dumitrescu-Ozimek L, Thal DR, Landreth G, Walter J, Klockgether T, van Leuven F, Heneka MTet al., 2006, Nonsteroidal anti-inflammatory drugs repress β-secretase gene promoter activity by the activation of PPARγ, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 103, Pages: 443-448, ISSN: 0027-8424

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• Citations: 338

Rossner S, Sastre M, Bourne K, Lichtenthaler SFet al., 2006, Transcriptional and translational regulation of BACE1 expression – Implications for Alzheimer’s disease., Progress in Neurobiology, Vol: 79, Pages: 95-111

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