Imperial College London
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ProfessorMagdalenaSastre

Faculty of Medicine, Department of Brain Sciences

Professor in Molecular Neuroscience
 
 
 
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Contact

 

+44 (0)20 7594 6673m.sastre

 
 
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Location

 

406Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sastre:2015,
author = {Sastre, M and Ritchie, CW and Hajji, N},
journal = {JSM Alzheimer’s Disease and Related Dementia},
title = {Metal Ions in Alzheimer’s disease brain},
url = {http://hdl.handle.net/10044/1/23400},
volume = {2},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - There is substantial evidence supporting a critical role for metal ions in thepathogenesis of Alzheimer’s disease (AD). This originated with the observation thatcertain metal ions (principally copper, iron and zinc) are enriched in the neuriticplaques of AD brains, leading to an overall reduction in their bioavailability, suchas in the synaptic cleft. Imbalances of metal ions associated with aging and AD mayaffect the disease progression, leading to metals being reduced or increased fromtheir physiological steady state. Because metals ions are essential cofactors for manyproteins and they can compete with each other for binding to proteins, it is essentialto maintain metal homeostasis in order to preserve neuronal function. Some heavymetals may aggravate the progression of the disease due to their high neurotoxicityand their ability to induce epigenetic changes. On the other hand, alterations inthe levels of certain metal ions in other compartments in the brain could affect Aβenzymatic degradation, increase Aβ and tau aggregation as well as the processing ofthe amyloid precursor protein (APP) and other intracellular processes. Metal ions arealso instrumental in enhancing the production of reactive oxygen species in the brain,which could have consequences for neuronal viability and function. Here we review thestudies reporting the concentrations in brain, CSF and plasma in AD patients and howalterations in their transport and storage mechanisms can lead to their redistribution inthe brain, contributing to AD neuropathology.
AU  - Sastre,M
AU  - Ritchie,CW
AU  - Hajji,N
PY  - 2015///
TI  - Metal Ions in Alzheimer’s disease brain
T2  - JSM Alzheimer’s Disease and Related Dementia
UR  - http://hdl.handle.net/10044/1/23400
VL  - 2
ER  -
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