Imperial College London
Alternate

ProfessorMichaelSeckl

Faculty of Medicine, Department of Surgery & Cancer

Professor of Molecular Cancer Medicine
 
 
 
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Contact

 

+44 (0)20 3311 1421m.seckl

 
 
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Location

 

08Cyclotron buildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

297 results found

Marinov M, Ziogas A, Pardo OE, Tan LT, Dhillon T, Mauri FA, Lane HA, Lemoine NR, Zangemeister-Wittke U, Seckl MJ, Arcaro Aet al., 2009, AKT/mTOR Pathway Activation and BCL-2 Family Proteins Modulate the Sensitivity of Human Small Cell Lung Cancer Cells to RAD001, CLINICAL CANCER RESEARCH, Vol: 15, Pages: 1277-1287, ISSN: 1078-0432

Journal article

MacKinnon AC, Tufail-Hanif U, Wheatley M, Rossi AG, Haslett C, Seckl M, Sethi Tet al., 2009, Targeting V<sub>1A</sub>-vasopressin receptors with [Arg<SUP>6</SUP>, D-Trp<SUP>7,9</SUP>, N<SUP>me</SUP>Phe<SUP>8</SUP>]-substance P (6-11) identifies a strategy to develop novel anti-cancer therapies, BRITISH JOURNAL OF PHARMACOLOGY, Vol: 156, Pages: 36-47, ISSN: 0007-1188

Journal article

Patten DK, Lindsay I, Fisher R, Sebire N, Savage PM, Seckl MJet al., 2008, Gestational Choriocarcinoma Mimicking a Uterine Adenocarcinoma, JOURNAL OF CLINICAL ONCOLOGY, Vol: 26, Pages: 5126-5127, ISSN: 0732-183X

Journal article

Kemp SJ, Thorley AJ, Gorelik J, Seckl MJ, O'Hare MJ, Arcaro A, Korchev Y, Goldstraw P, Tetley TDet al., 2008, Immortalization of Human Alveolar Epithelial Cells to Investigate Nanoparticle Uptake, AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Vol: 39, Pages: 591-597, ISSN: 1044-1549

Journal article

Savage P, Seckl M, Short D, 2008, Practical Issues in the Management of Low-Risk Gestational Trophoblast Tumors, 14th World Congress on Gestational Trophoblastic Diseases, Publisher: SCI PRINTERS & PUBL INC, Pages: 774-780, ISSN: 0024-7758

Conference paper

Sebire NJ, Fisher RA, Williams S, Prendergast G, Savage P, Seckl Met al., 2008, Indoleamine 2,3-Dioxygenase Expression in Gestational Trophoblastic Disease Implications for Development of Immunotherapeutic Approaches, JOURNAL OF REPRODUCTIVE MEDICINE, Vol: 53, Pages: 789-792, ISSN: 0024-7758

Journal article

Savage P, Seckl M, Short D, 2008, Practical issues in the management of low-risk gestational trophoblast tumors., J Reprod Med, Vol: 53, Pages: 774-780, ISSN: 0024-7758

Using data primarily from Charing Cross Hospital in London, we examined the organization and funding of patients' care and follow-up, the value of second evacuations, the indications for treatment escalation and the results of treating patients with persistent low levels of human chorionic gonadotropin (hCG) following a molar pregnancy. In the U.K. system the total cost per patient treated is approximately $30,000. Second evacuations appear to have only a modest chance (18%) of benefit in patients with hCG levels over 5,000 IU/L. Outcome analysis of patients with low-risk gestational trophoblastic tumor (GTT) treated with methotrexate/folinic acid indicates that hCG levels in excess of500 IU/L at 7 weeks after starting are an accurate predictor of impending methotrexate resistance. For patients with hCG values under 100 IU/L at the time of treatment, a review of the 30 most recent low-risk GTT patients demonstrates a 100% cure rate with standard treatment. Low-risk GTT following a molar pregnancy is a highly curable malignancy, and cure rates approaching 100% should be expected. National or regional organization of follow-up and treatment is simple, economic and associated with enhanced outcomes when appropriate treatment policies are followed.

Journal article

do Carmo CR, Seckl MJ, Costa-Pereira AP, 2008, A role for JAKs and STATs in chemoresistance?, 7th Joint Conference of the International-Cytokine-Society/International-Society-for-Interferon-and-Cytoklin-Research, Publisher: ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, Pages: 238-238, ISSN: 1043-4666

Conference paper

Wang J, Short D, Sebire NJ, Lindsay I, Newlands ES, Schmid P, Savage PM, Seckl MJet al., 2008, Salvage chemotherapy of relapsed or high-risk gestational trophoblastic neoplasia (GTN) with paclitaxel/cisplatin alternating with paclitaxel/etoposide (TP/TE), ANNALS OF ONCOLOGY, Vol: 19, Pages: 1578-1583, ISSN: 0923-7534

Journal article

Sebire NJ, Seckl MJ, 2008, Gestational trophoblastic disease: current management of hydatidiform mole, BMJ-BRITISH MEDICAL JOURNAL, Vol: 337, ISSN: 1756-1833

Journal article

Lim AKP, Patel D, Patel N, Hawtin K, Dayal L, Schmid P, Savage P, Seckl MJet al., 2008, Pelvic Imaging in Gestational Trophoblastic Neoplasia, JOURNAL OF REPRODUCTIVE MEDICINE, Vol: 53, Pages: 575-578, ISSN: 0024-7758

Journal article

Harvey RA, Pursglove HD, Schmid P, Savage PM, Mitchell HDC, Seckl MJet al., 2008, Human Chorionic Gonadotropin Free β-Subunit Measurement as a Marker of Placental Site Trophoblastic Tumors, JOURNAL OF REPRODUCTIVE MEDICINE, Vol: 53, Pages: 643-648, ISSN: 0024-7758

Journal article

Ong TA, Winkler MH, Savage PM, Seckl MJ, Christmas TJet al., 2008, Retroperitoneal lymph node dissection after chemotherapy in patients with elevated tumour markers: indications, histopathology and outcome, BJU INTERNATIONAL, Vol: 102, Pages: 198-202, ISSN: 1464-4096

Journal article

Hackshaw A, Farrant H, Bulley S, Seckl MJ, Ledermann JAet al., 2008, Setting up non-commercial clinical trials takes too long in the UK: findings from a prospective study, JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, Vol: 101, Pages: 299-304, ISSN: 0141-0768

Journal article

Collier K, Schink C, Young AM, How K, Seckl M, Savage Pet al., 2008, Successful treatment with etoposide phosphate in patients with previous etoposide hypersensitivity., J Oncol Pharm Pract, Vol: 14, Pages: 51-55, ISSN: 1078-1552

OBJECTIVE: To review the experience of treatment with etoposide phosphate in patients with acute etoposide hypersensitivity treated in a large tertiary referral center hospital specializing in curable malignancies. CASE SUMMARIES: The cases of 6 patients with advanced malignancies who experienced acute etoposide hypersensitivity are documented. There were 3 male and 3 female patients and their ages ranged from 16 to 68. Four patients had curable malignancies with trophoblast tumors or germ cell tumors and two were receiving palliative chemotherapy for other malignancies. All of the 6 patients who experienced etoposide hypersensitivity developed their symptoms in the first few minutes of the initial infusion. The most common symptoms were chest pain, facial flushing, and bronchospasm. All of the patients had emergency treatment with discontinuation of the infusion and usually the administration of hydrocortisone and chlorpheniramine, which lead to the rapid resolution of their symptoms. For the next cycle of chemotherapy each patient was rechallenged with etoposide phosphate, with steroid cover given in only two of the cases. None of the 6 patients experienced any hypersensitivity symptoms on treatment with etoposide phosphate and in one the steroids were withdrawn for all the subsequent cycles. The 4 patients with curable malignancies all remain disease free, while the 2 palliative patients obtained significant control of their disease. DISCUSSION: Etoposide is one of the most important chemotherapy drugs in the treatment of many curable malignancies but an acute hypersensitivity reaction occurs in around 1% of patients. Retreatment with etoposide in these patients is difficult and generally alternative drugs/regimens have to be used. A small number of case reports have suggested that etoposide phosphate can be safely used in these patients and 6 cases have been found in the pharmacy records where this has been done. In all of the patients, treatment with etoposide

Journal article

Marinov M, Ziogas A, Pardo OE, Tan LT, Lane HA, Lemoine NR, Zangemeister-Wittke U, Seckl MJ, Arcaro Aet al., 2007, Akt/mTOR pathway activation and Bcl-2 family proteins modulate the sensitivity of human small cell lung cancer cells to RAD001 (Everolimus), MOLECULAR CANCER THERAPEUTICS, Vol: 6, Pages: 3409S-3409S, ISSN: 1535-7163

Journal article

Fisher RA, Savage PM, MacDermott C, Hook J, Sebire NJ, Lindsay I, Seckl MJet al., 2007, The impact of molecular genetic diagnosis on the management of women with hCG-producing malignancies, GYNECOLOGIC ONCOLOGY, Vol: 107, Pages: 413-419, ISSN: 0090-8258

Journal article

Oladipo A, Mathew J, Oriolowo A, Lindsay I, Fisher R, Seckl M, Yiannakis Det al., 2007, Nongestational choriocarcinoma arising from a primary ovarian tumour, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 114, Pages: 1298-1300, ISSN: 1470-0328

Journal article

Willis SF, Winkler M, Savage P, Seckl MJ, Christmas TJet al., 2007, Repeat retroperitoneal lymph-node dissection after chemotherapy for metastatic testicular germ cell tumour, BJU INTERNATIONAL, Vol: 100, Pages: 809-812, ISSN: 1464-4096

Journal article

Ngan S, Seckl MJ, 2007, Gestational trophoblastic neoplasia management: an update, CURRENT OPINION IN ONCOLOGY, Vol: 19, Pages: 486-491, ISSN: 1040-8746

Journal article

Doumplis D, Al-Khatib K, Sieunarine K, Lindsay I, Seckl M, Bridges J, Smith JRet al., 2007, A review of the management by hysterectomy of 25 cases of gestational trophoblastic tumours from March 1993 to January 2006, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 114, Pages: 1168-1171, ISSN: 1470-0328

Journal article

Wang J, Cook G, Frank J, Dina R, Livni N, Lynn J, Fleming W, Seckl MJet al., 2007, Case report: PET/CT, a cautionary tale, BMC CANCER, Vol: 7, ISSN: 1471-2407

Journal article

Pfeffer PE, Sebire N, Lindsay L, McIndoe A, Lim A, Seckl MJet al., 2007, Fertility-sparing partial hysterectomy for placental-site trophoblastic tumour, LANCET ONCOLOGY, Vol: 8, Pages: 744-746, ISSN: 1470-2045

Journal article

Palmieri C, Dhillon T, Fisher RA, Young A-M, Short D, Mitchell H, Aghajanian C, Savage PM, Newlands ES, Hancock BW, Seckl MJet al., 2007, Management and outcome of healthy women with a persistently elevated β-hCG, GYNECOLOGIC ONCOLOGY, Vol: 106, Pages: 35-43, ISSN: 0090-8258

Journal article

Sebire NJ, Foskett M, Short D, Savage P, Stewart W, Thomson M, Seckl MJet al., 2007, Shortened duration of human chorionic gonadotrophin surveillance following complete or partial hydatidiform mode: evidence for revised protocol of a UK regional trophoblastic disease unit, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 114, Pages: 760-762, ISSN: 1470-0328

Journal article

Gabriel I, Chaidos A, Giles C, Apperley J, Seckl M, Bower M, Kanfer Eet al., 2007, The role of high dose chemotherapy and peripheral blood stem cell support in refractory trophoblastic disease and non-gestational choriocarcinoma: A review of eight patients, 12th Congress of the European-Hematology-Association, Publisher: FERRATA STORTI FOUNDATION, Pages: 185-185, ISSN: 0390-6078

Conference paper

Goldstraw MA, Christmas T, Seckl MJ, 2007, The fibroblast growth factor receptor inhibitor PD0173074 as a potential novel anti-prostate cancer therapy, Annual Meeting of the British-Association-of-Urological-Surgeons, Publisher: BLACKWELL PUBLISHING, Pages: 29-29, ISSN: 1464-4096

Conference paper

Arcaro A, Aubert M, del Hierro MEE, Khanzada UK, Angelidou S, Tetley TD, Bittermann AG, Frame MC, Seckl MJet al., 2007, Critical role for lipid raft-associated Src kinases in activation of PI3K-Akt signalling, CELLULAR SIGNALLING, Vol: 19, Pages: 1081-1092, ISSN: 0898-6568

Journal article

Patterson DM, Murugaesu N, Holden L, Seckl MJ, Rustin GJSet al., 2007, A review of the close surveillance policy for stage I female germ cell tumors of the ovary and other sites, INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Vol: 18, Pages: 43-50, ISSN: 1048-891X

Journal article

Milingos D, Doumplis D, Savage P, Seckl M, Lindsay I, Smith JRet al., 2007, Placental site trophoblastic tumor with an ovarian metastasis, INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Vol: 17, Pages: 925-927, ISSN: 1048-891X

Journal article

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