Publications
297 results found
Goldstraw M, Seckl M, Christmas T, 2007, The fibroblast growth factor receptor inhibitor PD0173074 as a potential novel anti-prostate cancer therapy, EUROPEAN UROLOGY SUPPLEMENTS, Vol: 6, Pages: 83-83, ISSN: 1569-9056
Powles T, Savage PM, Stebbing J, et al., 2007, A comparison of patients with relapsed and chemo-refractory gestational trophoblastic neoplasia, British Journal of Cancer, Vol: 96, Pages: 732-737, ISSN: 1532-1827
The majority of women requiring chemotherapy for gestational trophoblastic disease (GTN) are cured with their initial chemotherapy treatment. However, a small percentage either become refractory to treatment, or relapse after the completion of treatment. This study investigates the characteristics and outcome of these patients. Patients were identified from the Charing Cross Hospital GTD database. The outcome of these patients with relapsed disease was compared to those with refractory disease. Between 1980 and 2004, 1708 patients were treated with chemotherapy for GTN. Sixty (3.5%) patents relapsed following completion of initial therapy. The overall 5-year survival for patients with relapsed GTN was 93% (95% CI 86–100%). The overall survival for patients with low-risk and high-risk disease at presentation, who subsequently relapsed was 100% (n=35), and 84% (n=25) (95% CI: 66–96%: P<0.05), respectively. Eleven patients were identified who failed to enter remission and had refractory disease. These patients had a worse outcome compared to patients with relapsed disease (5-year survival 43% (95% CI:12–73% P<0.01)). The outcome of patients with relapsed GTN is good. However, patients with primary chemo-refractory disease do poorly and novel therapies are required for this group of patients.
Mitchell H, Seckl MJ, 2007, Discrepancies between commercially available immunoassays in the detection of tumour-derived hCG, MOLECULAR AND CELLULAR ENDOCRINOLOGY, Vol: 260, Pages: 310-313, ISSN: 0303-7207
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- Citations: 22
Fowler DJ, Lindsay I, Seckl MJ, et al., 2007, Histomorphometric features of hydatidiform moles in early pregnancy: relationship to detectability by ultrasound examination, ULTRASOUND IN OBSTETRICS & GYNECOLOGY, Vol: 29, Pages: 76-80, ISSN: 0960-7692
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- Citations: 29
Seckl MJ, 2007, HCG in diagnosis and management of gestational trophoblastic disease (GTD), 35th Meeting of the International-Society-for-Oncodevelopmental-Biology-and-Medicine, Publisher: KARGER, Pages: 16-16, ISSN: 1010-4283
Powles T, Young A, Sanitt A, et al., 2006, The significance of the time interval between antecedent pregnancy and diagnosis of high-risk gestational trophoblastic tumours (vol 95, pg 1145, 2006), BRITISH JOURNAL OF CANCER, Vol: 95, Pages: 1709-1709, ISSN: 0007-0920
Burke B, Sebire NJ, Moss J, et al., 2006, Evaluation of deletions in 7q11.2 and 8p12-p21 as prognostic indicators of tumour development following molar pregnancy, GYNECOLOGIC ONCOLOGY, Vol: 103, Pages: 642-648, ISSN: 0090-8258
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- Citations: 13
Mitchell H, Bagshawe KD, Newlands ES, et al., 2006, Importance of accurate human chorionic gonadotropin measurement in the treatment of gestational trophoblast disease and testicular cancer, JOURNAL OF REPRODUCTIVE MEDICINE, Vol: 51, Pages: 868-870, ISSN: 0024-7758
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- Citations: 10
Dhillo WS, Savage P, Murphy KG, et al., 2006, Plasma kisspeptin is raised in patients with gestational trophoblastic neoplasia and falls during treatment, AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, Vol: 291, Pages: E878-E884, ISSN: 0193-1849
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- Citations: 66
Dhillon T, Palmieri C, Sebire NJ, et al., 2006, Value of whole body <SUP>18</SUP>FDG-PET to identify the active site of gestational trophoblastic neoplasia, JOURNAL OF REPRODUCTIVE MEDICINE, Vol: 51, Pages: 879-887, ISSN: 0024-7758
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- Citations: 34
Murugaesu N, Schmid P, Dancey G, et al., 2006, Malignant ovarian germ cell tumors: Identification of novel prognostic markers and long-term outcome after multimodality treatment, JOURNAL OF CLINICAL ONCOLOGY, Vol: 24, Pages: 4862-4866, ISSN: 0732-183X
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- Citations: 109
Powles T, Young A, Sammit A, et al., 2006, The significance of the time interval between antecedent pregnancy and diagnosis of high-risk gestational trophoblastic tumours, British Journal of Cancer, Vol: 95, Pages: 1145-1147, ISSN: 1532-1827
Zhao J, Xiang Y, Huang S-Z, et al., 2006, [Genetic heterogeneity for familial recurrent hydatidiform mole]., Zhonghua Yi Xue Yi Chuan Xue Za Zhi, Vol: 23, Pages: 511-514, ISSN: 1003-9406
OBJECTIVE: To determine the parental origin of the genome in the molar pregnancies of two familes with familial recurrent hydatidiform mole (FRHM) and to investigate whether the gene responsible for FRHM is likely to be located within the 19q13.4 region in these familes. METHODS: The features of complete hydatidiform mole (CHM) were confirmed by pathological examination. DNA of CHM was prepared from sections of formalin-fixed paraffin-embedded blocks of molar tissue following laser capture microdissection. The polymerace chain reaction was used to amplify microsatellite polymorphisms in DNA from the patients, their husbands and the captured molar tissue. Parental contributions to the molar tissue were determined using ABI 310 GeneScan software. Genotyping and haplotype analysis of the candidate region on 19q13.4 was performed for members of both families using 25 microsatellite markers. RESULTS: One CHM from each family was identified as a biparental complete hydatidiform mole. All patients were heterozygous for most of the markers in the chromosome region of interest. In addition the two affected sisters in one of the families had different genotypes for the 19q13.4 region, suggesting that mutations in a different locus might be responsible for the disorder in this family. CONCLUSION: The location of the gene responsible for FRHM is unlikely to be located in the 19q13.4 chromosomal region in these two families suggesting that FRHM shows genetic heterogeneity.
Nagai Y, Sebire NJ, Paradinas FJ, et al., 2006, Placental site trophoblastic tumor (PSTT) treated at Charing Cross Hospital over 30 years, 12th Meeting of the International-Federation-of-Placenta-Association, Publisher: W B SAUNDERS CO LTD, Pages: A56-A56, ISSN: 0143-4004
Willis S, Goldstraw M, Christmas T, et al., 2006, Fibroblast growth factor 2 (FGF-2), a growth factor known to cause chemoresistance in prostate cancer, cannot prevent death induced by a novel Src kinase inhibitor in-vltro, EUROPEAN UROLOGY SUPPLEMENTS, Vol: 5, Pages: 796-796, ISSN: 1569-9056
Cole LA, Butler SA, Khanlian SA, et al., 2006, Gestational trophoblastic diseases: 2. Hyperglycosylated hCG as a reliable marker of active neoplasia, GYNECOLOGIC ONCOLOGY, Vol: 102, Pages: 151-159, ISSN: 0090-8258
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- Citations: 84
Pardo OE, Wellbrock C, Khanzada UK, et al., 2006, FGF-2 protects small cell lung cancer cells from apoptosis through a complex involving PKCε, B-Raf and S6K2, EMBO JOURNAL, Vol: 25, Pages: 3078-3088, ISSN: 0261-4189
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- Citations: 150
Powles T, Young A, Short D, et al., 2006, The outcome of patients with relapsed gestational trophoblastic neoplasm (GTN) after the completion of chemotherapy., 42nd Annual Meeting of the American-Society-of-Clinical-Oncology, Publisher: AMER SOC CLINICAL ONCOLOGY, Pages: 263S-263S, ISSN: 0732-183X
Allen SD, Lim AK, Seckl MJ, et al., 2006, Radiology of gestational trophoblastic neoplasia, CLINICAL RADIOLOGY, Vol: 61, Pages: 301-313, ISSN: 0009-9260
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- Citations: 69
Khan S, Dancey G, Lindsay I, et al., 2006, Placental site trophoblastic tumour derived from an oocyte donation pregnancy, BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, Vol: 113, Pages: 344-346, ISSN: 1470-0328
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- Citations: 6
Khanzada UK, Pardo OE, Meier C, et al., 2006, Potent inhibition of small-cell lung cancer cell growth by simvastatin reveals selective functions of Ras isoforms in growth factor signalling, ONCOGENE, Vol: 25, Pages: 877-887, ISSN: 0950-9232
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- Citations: 97
Zhao J, Moss J, Sebire NJ, et al., 2006, Analysis of the chromosomal region 19q13.4 in two Chinese families with recurrent hydatidiform mole, HUMAN REPRODUCTION, Vol: 21, Pages: 536-541, ISSN: 0268-1161
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- Citations: 16
Powles T, Savage P, Short D, et al., 2006, Residual lung lesions after completion of chemotherapy for gestational trophoblastic neoplasia: should we operate?, BRITISH JOURNAL OF CANCER, Vol: 94, Pages: 51-54, ISSN: 0007-0920
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- Citations: 24
Fowler DJ, Lindsay I, Seckl MJ, et al., 2006, Routine pre-evacuation ultrasound diagnosis of hydatidiform mole: experience of more than 1000 cases from a regional referral center, ULTRASOUND IN OBSTETRICS & GYNECOLOGY, Vol: 27, Pages: 56-60, ISSN: 0960-7692
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- Citations: 95
Onganer PU, Seckl MJ, Djamgoz MBA, 2005, Neuronal characteristics of small-cell lung cancer, BRITISH JOURNAL OF CANCER, Vol: 93, Pages: 1197-1201, ISSN: 0007-0920
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- Citations: 65
Fowler DJ, Lindsay I, Seckl M, et al., 2005, Pathological-ultrasound correlation of routine sonographic examination in the diagnosis of hydatidiform mole:: experience of >1,000 cases from a regional centre, 3rd Joint Meeting of the British Division of the International-Academy-of-Pathology/Meeting of the Pathological-Society-of-Great-Britain-and-Ireland, Publisher: JOHN WILEY & SONS LTD, Pages: 18-18, ISSN: 0022-3417
Fowler DJ, Lindsay I, Seckl M, et al., 2005, Diagnosis of intraplacental choriocarcinoma and relationship with infantile choriocarcinoma: Four additional cases, 3rd Joint Meeting of the British Division of the International-Academy-of-Pathology/Meeting of the Pathological-Society-of-Great-Britain-and-Ireland, Publisher: JOHN WILEY & SONS LTD, Pages: 18-18, ISSN: 0022-3417
Savage P, Seckl MJ, 2005, The role of repeat uterine evacuation in trophoblast disease, GYNECOLOGIC ONCOLOGY, Vol: 99, Pages: 251-252, ISSN: 0090-8258
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- Citations: 17
Lindsay I, Fowler DJ, Fisher R, et al., 2005, Role of central review for the histopathological diagnosis of complete and partial hydatidiform moles in southern England, 3rd Joint Meeting of the British Division of the International-Academy-of-Pahtology/Meeting of the Pathological-Society-of-Great-Britian-and-Ireland, Publisher: JOHN WILEY & SONS LTD, Pages: 18-18, ISSN: 0022-3417
Sebire NJ, Lindsay I, Seckl M, 2005, Difficulties in the histopathological diagnosis of tubal complete and partial hydatidiform moles, 3rd Joint Meeting of the British Division of the International-Academy-of-Pahtology/Meeting of the Pathological-Society-of-Great-Britian-and-Ireland, Publisher: JOHN WILEY & SONS LTD, Pages: 18-18, ISSN: 0022-3417
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