Imperial College London
Alternate

ProfessorMichaelSeckl

Faculty of Medicine, Department of Surgery & Cancer

Professor of Molecular Cancer Medicine
 
 
 
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Contact

 

+44 (0)20 3311 1421m.seckl

 
 
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Location

 

08Cyclotron buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Coyle:2017:10.1016/j.ygyno.2017.12.008,
author = {Coyle, C and Short, D and Jackson, L and Sebire, NJ and Kaur, B and Harvey, R and Savage, PM and Seckl, MJ},
doi = {10.1016/j.ygyno.2017.12.008},
journal = {Gynecologic Oncology},
pages = {254--257},
title = {What is the optimal duration of human chorionic gonadotrophin surveillance following evacuation of a molar pregnancy? A retrospective analysis on over 20,000 consecutive patients.},
url = {http://dx.doi.org/10.1016/j.ygyno.2017.12.008},
volume = {148},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVE: To quantify the risk of developing post-molar gestational trophoblastic neoplasia (pGTN) beyond the first normal human chorionic gonadotrophin (hCG) in women who have had a complete (CHM) or partial molar pregnancy (PHM) and to re-evaluate the current UK Hydatidiform mole hCG surveillance guidelines. METHODS: The Charing Cross Hospital Trophoblast Disease Centre database was screened to identify all registered cases of hydatidiform mole (HM) between 1980 and 2009. RESULTS: We identified 20,144 cases of HM, comprising 8400 CHM, 9586 PHM, and 2158 cases of unclassified hydatidiform mole (UHM). Twenty-nine cases (20 CHM, 3 PHM and 6 UHM) developed pGTN after the first normal hCG. For CHM the risk of pGTN at the point of hCG normalisation was 1 in 406, and fell rapidly in the first six months of monitoring. For PHM the risk of pGTN at the point of hCG normalisation was 1 in 3195. Women with CHM where hCG normalisation occurred beyond 56days after uterine evacuation of molar tissue were found to have a 3.8-fold higher risk of pGTN. CONCLUSIONS: Our results show that pGTN can occur after hCG normalisation following PHM but the risk is extremely low. Women with CHM have a comparatively higher risk of pGTN after hCG normalisation. Those with CHM where hCG normalises within 56days have a lower risk of pGTN. We have revised the current UK hCG surveillance protocol for PHM to a single additional confirmatory normal urine hCG measurement one month after first normalisation. The protocol for CHM remains unchanged.
AU  - Coyle,C
AU  - Short,D
AU  - Jackson,L
AU  - Sebire,NJ
AU  - Kaur,B
AU  - Harvey,R
AU  - Savage,PM
AU  - Seckl,MJ
DO  - 10.1016/j.ygyno.2017.12.008
EP  - 257
PY  - 2017///
SN  - 0090-8258
SP  - 254
TI  - What is the optimal duration of human chorionic gonadotrophin surveillance following evacuation of a molar pregnancy? A retrospective analysis on over 20,000 consecutive patients.
T2  - Gynecologic Oncology
UR  - http://dx.doi.org/10.1016/j.ygyno.2017.12.008
UR  - http://hdl.handle.net/10044/1/56151
VL  - 148
ER  -
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