Imperial College London

Prof Milo Shaffer

Faculty of Natural SciencesDepartment of Chemistry

Professor of Materials Chemistry
 
 
 
//

Contact

 

+44 (0)20 7594 5825m.shaffer

 
 
//

Assistant

 

Mr John Murrell +44 (0)20 7594 2845

 
//

Location

 

M221Royal College of ScienceSouth Kensington Campus

//

Summary

 

Publications

Publication Type
Year
to

225 results found

Goode AE, Hine NDM, Chen S, Bergin SD, Shaffer MSP, Ryan MP, Haynes PD, Porter AE, McComb DWet al., Mapping functional groups on oxidised multi-walled carbon nanotubes at the nanometre scale, Chemical Communications, ISSN: 1364-548X

JOURNAL ARTICLE

Clancy AJ, Anthony DB, Fisher SJ, Leese HS, Roberts CS, Shaffer MSPet al., 2017, Reductive dissolution of supergrowth carbon nanotubes for tougher nanocomposites by reactive coagulation spinning, NANOSCALE, Vol: 9, Pages: 8764-8773, ISSN: 2040-3364

JOURNAL ARTICLE

Garcia-Trenco A, White ER, Regoutz A, Payne DJ, Shaffer MSP, Williams CKet al., 2017, Pd2Ga-Based Colloids as Highly Active Catalysts for the Hydrogenation of CO2 to Methanol, ACS CATALYSIS, Vol: 7, Pages: 1186-1196, ISSN: 2155-5435

JOURNAL ARTICLE

Gonzalez Carter DA, Leo BF, Ruenraroengsak P, Chen S, Goode A, Theodorou I, Chung KF, Carzaniga R, Shaffer M, Dexter D, Ryan M, Porter Aet al., 2017, Silver nanoparticles reduce brain inflammation and related neurotoxicity through induction of H2S-synthesizing enzymes, Scientific Reports, Vol: 7, ISSN: 2045-2322

Silver nanoparticles (AgNP) are known to penetrate into the brain and cause neuronal death. However, there is a paucity in studies examining the effect of AgNP on the resident immune cells of the brain, microglia. Given microglia are implicated in neurodegenerative disorders such as Parkinson’s disease (PD), it is important to examine how AgNPs affect microglial inflammation to fully assess AgNP neurotoxicity. In addition, understanding AgNP processing by microglia will allow better prediction of their long term bioreactivity. In the present study, the in vitro uptake and intracellular transformation of citrate-capped AgNPs by microglia, as well as their effects on microglial inflammation and related neurotoxicity were examined. Analytical microscopy demonstrated internalization and dissolution of AgNPs within microglia and formation of non-reactive silver sulphide (Ag2S) on the surface of AgNPs. Furthermore, AgNP-treatment up-regulated microglial expression of the hydrogen sulphide (H2S)-synthesizing enzyme cystathionine-γ-lyase (CSE). In addition, AgNPs showed significant anti-inflammatory effects, reducing lipopolysaccharide (LPS)-stimulated ROS, nitric oxide and TNFα production, which translated into reduced microglial toxicity towards dopaminergic neurons. Hence, the present results indicate that intracellular Ag2S formation, resulting from CSE-mediated H2S production in microglia, sequesters Ag+ ions released from AgNPs, significantly limiting their toxicity, concomitantly reducing microglial inflammation and related neurotoxicity.

JOURNAL ARTICLE

Gonzalez-Carter DA, Leo BF, Ruenraroengsak P, Chen S, Goode AE, Theodorou IG, Chung KF, Carzaniga R, Shaffer MSP, Dexter DT, Ryan MP, Porter AEet al., 2017, Silver nanoparticles reduce brain inflammation and related neurotoxicity through induction of H2S-synthesizing enzymes, SCIENTIFIC REPORTS, Vol: 7, ISSN: 2045-2322

JOURNAL ARTICLE

Hart M, White ER, Chen J, McGilvery CM, Pickard CJ, Michaelides A, Sella A, Shaffer MSP, Salzmann CGet al., 2017, Encapsulation and Polymerization of White Phosphorus Inside Single-Wall Carbon Nanotubes, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 56, Pages: 8144-8148, ISSN: 1433-7851

JOURNAL ARTICLE

Hodge SA, Buckley DJ, Yau HC, Skipper NT, Howard CA, Shaffer MSPet al., 2017, Chemical routes to discharging graphenides, NANOSCALE, Vol: 9, Pages: 3150-3158, ISSN: 2040-3364

JOURNAL ARTICLE

Pike SD, White ER, Regoutz A, Sammy N, Payne DJ, Williams CK, Shaffer MSPet al., 2017, Reversible Redox Cycling of Well-Defined, Ultrasmall Cu/Cu2O Nanoparticles, ACS NANO, Vol: 11, Pages: 2714-2723, ISSN: 1936-0851

JOURNAL ARTICLE

Robinson RK, Birrell MA, Adcock JJ, Wortley MA, Dubuis ED, Chen S, McGilvery CM, Hu S, Shaffer MSP, Bonvini SJ, Maher SA, Mudway IS, Porter AE, Carlsten C, Tetley TD, Belvisi MGet al., 2017, Mechanistic link between diesel exhaust particles and respiratory reflexes., J Allergy Clin Immunol

BACKGROUND: Diesel exhaust particles (DEPs) are a major component of particulate matter in Europe's largest cities, and epidemiologic evidence links exposure with respiratory symptoms and asthma exacerbations. Respiratory reflexes are responsible for symptoms and are regulated by vagal afferent nerves, which innervate the airway. It is not known how DEP exposure activates airway afferents to elicit symptoms, such as cough and bronchospasm. OBJECTIVE: We sought to identify the mechanisms involved in activation of airway sensory afferents by DEPs. METHODS: In this study we use in vitro and in vivo electrophysiologic techniques, including a unique model that assesses depolarization (a marker of sensory nerve activation) of human vagus. RESULTS: We demonstrate a direct interaction between DEP and airway C-fiber afferents. In anesthetized guinea pigs intratracheal administration of DEPs activated airway C-fibers. The organic extract (DEP-OE) and not the cleaned particles evoked depolarization of guinea pig and human vagus, and this was inhibited by a transient receptor potential ankyrin-1 antagonist and the antioxidant N-acetyl cysteine. Polycyclic aromatic hydrocarbons, major constituents of DEPs, were implicated in this process through activation of the aryl hydrocarbon receptor and subsequent mitochondrial reactive oxygen species production, which is known to activate transient receptor potential ankyrin-1 on nociceptive C-fibers. CONCLUSIONS: This study provides the first mechanistic insights into how exposure to urban air pollution leads to activation of guinea pig and human sensory nerves, which are responsible for respiratory symptoms. Mechanistic information will enable the development of appropriate therapeutic interventions and mitigation strategies for those susceptible subjects who are most at risk.

JOURNAL ARTICLE

Thong AZ, Shaffer MSP, Horsfield AP, 2017, HOMO-LUMO coupling: the fourth rule for highly effective molecular rectifiers, NANOSCALE, Vol: 9, Pages: 8119-8125, ISSN: 2040-3364

JOURNAL ARTICLE

Anthony DB, Shaffer MSP, 2016, Process for producing carbon-nanotube grafted substrate, WO 2016009207 A1

The present invention relates to a process for producing a carbon nanotube-grafted substrate, the process comprising: providing a substrate having catalytic material deposited thereon; and synthesising carbon nanotubes on the substrate by a chemical vapour deposition process in a reaction chamber; characterised in that the process comprises providing a counter electrode, applying a potential difference to the substrate in relation to the counter electrode and maintaining the potential difference of the substrate in relation to the counter electrode during the chemical vapour deposition process.

PATENT

Bayazit MK, Hodge SA, Clancy AJ, Menzel R, Chen S, Shaffer MSPet al., 2016, Carbon nanotube anions for the preparation of gold nanoparticle-nanocarbon hybrids, CHEMICAL COMMUNICATIONS, Vol: 52, Pages: 1934-1937, ISSN: 1359-7345

JOURNAL ARTICLE

Blaker JJ, Anthony DB, Tang G, Shamsuddin S-R, Kalinka G, Weinrich M, Abdolvand A, Shaffer MSP, Bismarck Aet al., 2016, Property and Shape Modulation of Carbon Fibers Using Lasers, ACS APPLIED MATERIALS & INTERFACES, Vol: 8, Pages: 16351-16358, ISSN: 1944-8244

JOURNAL ARTICLE

Chen S, Goode AE, Skepper JN, Thorley AJ, Seiffert JM, Chung KF, Tetley TD, Shaffer MSP, Ryan MP, Porter AEet al., 2016, Avoiding artefacts during electron microscopy of silver nanomaterials exposed to biological environments, JOURNAL OF MICROSCOPY, Vol: 261, Pages: 157-166, ISSN: 0022-2720

JOURNAL ARTICLE

Clancy AJ, White ER, Tay HH, Yau HC, Shaffer MSPet al., 2016, Systematic comparison of conventional and reductive single-walled carbon nanotube purifications, CARBON, Vol: 108, Pages: 423-432, ISSN: 0008-6223

JOURNAL ARTICLE

De Marco M, Markoulidis F, Menzel R, Bawaked SM, Mokhtar M, Al-Thabaiti SA, Basahel SN, Shaffer MSPet al., 2016, Cross-linked single-walled carbon nanotube aerogel electrodes via reductive coupling chemistry, JOURNAL OF MATERIALS CHEMISTRY A, Vol: 4, Pages: 5385-5389, ISSN: 2050-7488

JOURNAL ARTICLE

Diba M, Fam DWH, Boccaccini AR, Shaffer MSPet al., 2016, Electrophoretic deposition of graphene-related materials: A review of the fundamentals, PROGRESS IN MATERIALS SCIENCE, Vol: 82, Pages: 83-117, ISSN: 0079-6425

JOURNAL ARTICLE

Ferguson A, Khan U, Walsh M, Lee K-Y, Bismarck A, Shaffer MSP, Coleman JN, Bergin SDet al., 2016, Understanding the Dispersion and Assembly of Bacterial Cellulose in Organic Solvents, BIOMACROMOLECULES, Vol: 17, Pages: 1845-1853, ISSN: 1525-7797

JOURNAL ARTICLE

Garcia-Trenco A, White ER, Shaffer MSP, Williams CKet al., 2016, A one-step Cu/ZnO quasi-homogeneous catalyst for DME production from syn-gas, CATALYSIS SCIENCE & TECHNOLOGY, Vol: 6, Pages: 4389-4397, ISSN: 2044-4753

JOURNAL ARTICLE

Govada L, Leese HS, Saridakis E, Kassen S, Chain B, Khurshid S, Menzel R, Hu S, Shaffer MSP, Chayen NEet al., 2016, Exploring Carbon Nanomaterial Diversity for Nucleation of Protein Crystals, SCIENTIFIC REPORTS, Vol: 6, ISSN: 2045-2322

JOURNAL ARTICLE

Herceg TM, Abidin MSZ, Greenhalgh ES, Shaffer MSP, Bismarck Aet al., 2016, Thermosetting hierarchical composites with high carbon nanotube loadings: En route to high performance, Composites Science and Technology, Vol: 127, Pages: 134-141, ISSN: 0266-3538

A wet powder impregnation route to manufacture carbon fibre reinforced thermoplastic composites was adapted to accommodate thermosetting matrices reinforced with high fractions (20 wt%/13.6 vol%) of multiwalled carbon nanotubes (CNTs). The produced carbon fibre prepregs were consolidated into laminates with fibre volume fractions of 50–58% and up to 6.1 vol% CNTs. Microscopic imaging confirmed successful consolidation at intermediate CNT loadings, but some voidage at the highest CNT loading due to the highly viscoelastic uncured matrix. Nonetheless, through-thickness electrical conductivity and Mode I interlaminar fracture toughness were enhanced by as much as 152% and 24% to unprecedented values of σ = 53 S m−1 and GIC = 840 J m−2, respectively. Fractographic characterisation indicated that crack deflection was the mechanism responsible for the improved fracture toughness. The material properties were shown to be strongly dependent on the microstructure of the matrix.

JOURNAL ARTICLE

Herceg TM, Yoon S-H, Abidin MSZ, Greenhalgh ES, Bismarck A, Shaffer MSPet al., 2016, Thermosetting nanocomposites with high carbon nanotube loadings processed by a scalable powder based method, COMPOSITES SCIENCE AND TECHNOLOGY, Vol: 127, Pages: 62-70, ISSN: 0266-3538

JOURNAL ARTICLE

Javaid A, Ho KKC, Bismarck A, Steinke JHG, Shaffer MSP, Greenhalgh ESet al., 2016, Carbon fibre-reinforced poly(ethylene glycol) diglycidylether based multifunctional structural supercapacitor composites for electrical energy storage applications, JOURNAL OF COMPOSITE MATERIALS, Vol: 50, Pages: 2155-2163, ISSN: 0021-9983

JOURNAL ARTICLE

Lee WJ, Clancy AJ, Kontturi E, Bismarck A, Shaffer MSPet al., 2016, Strong and Stiff: High-Performance Cellulose Nanocrystal/Poly(vinyl alcohol) Composite Fibers, ACS Applied Materials & Interfaces, Vol: 8, Pages: 31500-31504, ISSN: 1944-8244

JOURNAL ARTICLE

Leese HS, Govada L, Saridakis E, Khurshid S, Menzel R, Morishita T, Clancy AJ, White ER, Chayen NE, Shaffer MSPet al., 2016, Reductively PEGylated carbon nanomaterials and their use to nucleate 3D protein crystals: a comparison of dimensionality, CHEMICAL SCIENCE, Vol: 7, Pages: 2916-2923, ISSN: 2041-6520

JOURNAL ARTICLE

Liberti E, Menzel R, Shaffer MSP, McComb DWet al., 2016, Probing the size dependence on the optical modes of anatase nanoplatelets using STEM-EELS, NANOSCALE, Vol: 8, Pages: 9727-9735, ISSN: 2040-3364

JOURNAL ARTICLE

Mansor N, Miller TS, Dedigama I, Jorge AB, Jia J, Brazdova V, Mattevi C, Gibbs C, Hodgson D, Shearing PR, Howard CA, Cora F, Shaffer M, Brett DJL, McMillan PFet al., 2016, Graphitic Carbon Nitride as a Catalyst Support in Fuel Cells and Electrolyzers, ELECTROCHIMICA ACTA, Vol: 222, Pages: 44-57, ISSN: 0013-4686

JOURNAL ARTICLE

Menzel R, Iruretagoyena D, Wang Y, Bawaked SM, Mokhtar M, Al-Thabaiti SA, Basahel SN, Shaffer MSPet al., 2016, Graphene oxide/mixed metal oxide hybrid materials for enhanced adsorption desulfurization of liquid hydrocarbon fuels, FUEL, Vol: 181, Pages: 531-536, ISSN: 0016-2361

JOURNAL ARTICLE

Pike SD, White ER, Shaffer MSP, Williams CKet al., 2016, Simple phosphinate ligands access zinc clusters identified in the synthesis of zinc oxide nanoparticles, NATURE COMMUNICATIONS, Vol: 7, ISSN: 2041-1723

JOURNAL ARTICLE

Ruenraromgsak P, Chen S, Hu S, Melbourne J, Sweeney S, Thorley AJ, Skepper JN, Shaffer MSP, Tetley TD, Porter AEet al., 2016, Translocation of Functionalized Multi-Walled Carbon Nanotubes across Human Pulmonary Alveolar Epithelium: Dominant Role of Epithelial Type 1 Cells, ACS NANO, Vol: 10, Pages: 5070-5085, ISSN: 1936-0851

JOURNAL ARTICLE

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://wlsprd.imperial.ac.uk:80/respub/WEB-INF/jsp/search-html.jsp Request URI: /respub/WEB-INF/jsp/search-html.jsp Query String: respub-action=search.html&id=00386229&limit=30&person=true