Imperial College London
Alternate

Prof Milo Shaffer

Faculty of Natural Sciences, Department of Chemistry

Professor of Materials Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 5825m.shaffer Website

 
 
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Assistant

 

Mr John Murrell +44 (0)20 7594 2845

 
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Location

 

401BMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Sehmi:2016:10.1021/acsomega.6b00017,
author = {Sehmi, SK and Noimark, S and Pike, SD and Bear, JC and Peveler, WJ and Williams, CK and Shaffer, MSP and Allan, E and Parkin, IP and MacRobert, AJ},
doi = {10.1021/acsomega.6b00017},
journal = {ACS OMEGA},
pages = {334--343},
title = {Enhancing the antibacterial activity of light-activated surfaces containing crystal violet and ZnO nanoparticles: investigation of nanoparticle size, capping ligand, and dopants},
url = {http://dx.doi.org/10.1021/acsomega.6b00017},
volume = {1},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Healthcare-associated infections pose a serious risk for patients, staff, and visitors and are a severe burden on the National Health Service, costing at least £1 billion annually. Antimicrobial surfaces significantly contribute toward reducing the incidence of infections as they prevent bacterial adhesion and cause bacterial cell death. Using a simple, easily upscalable swell–encapsulation–shrink method, novel antimicrobial surfaces have been developed by incorporating metal oxide nanoparticles (NPs) and crystal violet (CV) dye into medical-grade polyurethane sheets. This study compares the bactericidal effects of polyurethane incorporating ZnO, Mg-doped ZnO, and MgO. All metal oxide NPs are well defined, with average diameters ranging from 2 to 18 nm. These materials demonstrate potent bactericidal activity when tested against clinically relevant bacteria such as Escherichia coli and Staphylococcus aureus. Additionally, these composites are tested against an epidemic strain of methicillin-resistant Staphylococcus aureus (MRSA) that is rife in hospitals throughout the UK. Furthermore, we have tested these materials using a low light intensity (∼500 lx), similar to that present in many clinical environments. The highest activity is achieved from polymer composites incorporating CV and ∼3 nm ZnO NPs, and the different performances of the metal oxides have been discussed.
AU  - Sehmi,SK
AU  - Noimark,S
AU  - Pike,SD
AU  - Bear,JC
AU  - Peveler,WJ
AU  - Williams,CK
AU  - Shaffer,MSP
AU  - Allan,E
AU  - Parkin,IP
AU  - MacRobert,AJ
DO  - 10.1021/acsomega.6b00017
EP  - 343
PY  - 2016///
SN  - 2470-1343
SP  - 334
TI  - Enhancing the antibacterial activity of light-activated surfaces containing crystal violet and ZnO nanoparticles: investigation of nanoparticle size, capping ligand, and dopants
T2  - ACS OMEGA
UR  - http://dx.doi.org/10.1021/acsomega.6b00017
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000391204000002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/105990
VL  - 1
ER  -
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