Imperial College London

ProfessorMichaelSternberg

Faculty of Natural SciencesDepartment of Life Sciences

Director Centre for Bioinformatics
 
 
 
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Contact

 

+44 (0)20 7594 5212m.sternberg Website

 
 
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Location

 

306Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

321 results found

HIRST JD, STERNBERG MJE, 1993, PREDICTION OF ATP-BINDING MOTIFS - A COMPARISON OF A PERCEPTRON-TYPE NEURAL-NETWORK AND A CONSENSUS SEQUENCE METHOD (VOL 4, PG 615, 1991), PROTEIN ENGINEERING, Vol: 6, Pages: 549-554, ISSN: 0269-2139

JOURNAL ARTICLE

Hirst JD, Sternberg MJE, 1993, Corrigendum: Prediction of ATP/GTP-bindmg motifs: A comparison of a perceptron type neural network and a consensus sequence method (Protein Engineering (1993) 4 (615-623)), Protein Engineering, Vol: 6, ISSN: 0269-2139

JOURNAL ARTICLE

JACKSON RM, STERNBERG MJE, 1993, PROTEIN SURFACE-AREA DEFINED, NATURE, Vol: 366, Pages: 638-638, ISSN: 0028-0836

JOURNAL ARTICLE

King RD, Hirst JD, Sternberg MJE, 1993, New approaches to QSAR: Neural networks and machine learning, Perspectives in Drug Discovery and Design, Vol: 1, Pages: 279-290, ISSN: 0928-2866

Neural networks and machine learning are two methods that are increasingly being used to model QSARs. They make few statistical assumptions and are nonlinear and nonparametric. We describe back-propagation from the field of neural networks, and GOLEM from machine learning, and illustrate their learning mechanisms using a simple expository problem. Back-propagation and GOLEM are then compared with multiple linear regression (using the parameters and their squares) on two real drug design problems: the inhibition of Escherichia coli dihydrofolate reductase (DHFR) by pyrimidines and the inhibition of rat/mouse tumour DHFR by triazines. © 1993 ESCOM Science Publishers B.V.

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LOFTS FJ, HURST HC, STERNBERG MJE, GULLICK WJet al., 1993, SPECIFIC SHORT TRANSMEMBRANE SEQUENCES CAN INHIBIT TRANSFORMATION BY THE MUTANT NEU GROWTH-FACTOR RECEPTOR IN-VITRO AND IN-VIVO, ONCOGENE, Vol: 8, Pages: 2813-2820, ISSN: 0950-9232

JOURNAL ARTICLE

MUGGLETON S, KING RD, STERNBERG MJE, 1993, PROTEIN SECONDARY STRUCTURE PREDICTION USING LOGIC-BASED MACHINE LEARNING, PROTEIN ENGINEERING, Vol: 6, Pages: 549-549, ISSN: 0269-2139

JOURNAL ARTICLE

Muggleton BS, King RD, Sternberg MJE, 1993, Corrigendum: Protein secondary structure prediction using logic-based machine learning (Protein Engineering (1993) 5 (647-657)), Protein Engineering, Vol: 6, ISSN: 0269-2139

JOURNAL ARTICLE

PICKETT SD, STERNBERG MJE, 1993, EMPIRICAL SCALE OF SIDE-CHAIN CONFORMATIONAL ENTROPY IN PROTEIN-FOLDING, JOURNAL OF MOLECULAR BIOLOGY, Vol: 231, Pages: 825-839, ISSN: 0022-2836

JOURNAL ARTICLE

BATES PA, LUO JC, STERNBERG MJE, 1992, A PREDICTED 3-DIMENSIONAL STRUCTURE FOR THE CARCINOEMBRYONIC ANTIGEN (CEA), FEBS LETTERS, Vol: 301, Pages: 207-214, ISSN: 0014-5793

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BERENDT AR, MCDOWALL A, CRAIG AG, BATES PA, STERNBERG MJE, MARSH K, NEWBOLD CI, HOGG Net al., 1992, THE BINDING-SITE ON ICAM-1 FOR PLASMODIUM-FALCIPARUM INFECTED ERYTHROCYTES OVERLAPS, BUT IS DISTINCT FROM, THE LFA-1-BINDING SITE, CELL, Vol: 68, Pages: 71-81, ISSN: 0092-8674

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BURROUGHS AK, BUTLER P, STERNBERG MJE, BAUM Het al., 1992, MOLECULAR MIMICRY IN LIVER-DISEASE, NATURE, Vol: 358, Pages: 377-378, ISSN: 0028-0836

JOURNAL ARTICLE

GULLICK WJ, BOTTOMLEY AC, LOFTS FJ, DOAK DG, MULVEY D, NEWMAN R, CRUMPTON MJ, STERNBERG MJE, CAMPBELL IDet al., 1992, 3-DIMENSIONAL STRUCTURE OF THE TRANSMEMBRANE REGION OF THE PROTOONCOGENIC AND ONCOGENIC FORMS OF THE NEU PROTEIN, EMBO JOURNAL, Vol: 11, Pages: 43-48, ISSN: 0261-4189

JOURNAL ARTICLE

HIRST JD, STERNBERG MJE, 1992, PREDICTION OF STRUCTURAL AND FUNCTIONAL FEATURES OF PROTEIN AND NUCLEIC-ACID SEQUENCES BY ARTIFICIAL NEURAL NETWORKS, BIOCHEMISTRY, Vol: 31, Pages: 7211-7218, ISSN: 0006-2960

JOURNAL ARTICLE

KING RD, MUGGLETON S, LEWIS RA, STERNBERG MJEet al., 1992, DRUG DESIGN BY MACHINE LEARNING - THE USE OF INDUCTIVE LOGIC PROGRAMMING TO MODEL THE STRUCTURE-ACTIVITY-RELATIONSHIPS OF TRIMETHOPRIM ANALOGS BINDING TO DIHYDROFOLATE-REDUCTASE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 89, Pages: 11322-11326, ISSN: 0027-8424

JOURNAL ARTICLE

MUGGLETON S, KING RD, STERNBERG MJE, 1992, PROTEIN SECONDARY STRUCTURE PREDICTION USING LOGIC-BASED MACHINE LEARNING, PROTEIN ENGINEERING, Vol: 5, Pages: 647-657, ISSN: 0269-2139

JOURNAL ARTICLE

PICKETT SD, SAQI MAS, STERNBERG MJE, 1992, EVALUATION OF THE SEQUENCE TEMPLATE METHOD FOR PROTEIN-STRUCTURE PREDICTION - DISCRIMINATION OF THE (BETA/ALPHA)8-BARREL FOLD, JOURNAL OF MOLECULAR BIOLOGY, Vol: 228, Pages: 170-187, ISSN: 0022-2836

JOURNAL ARTICLE

Rees AR, Wetzel R, Sternberg MJE, 1992, Protein Engineering - A Practical Approach, Oxford, Publisher: Oxford University Press

BOOK

SAQI MAS, BATES PA, STERNBERG MJE, 1992, TOWARDS AN AUTOMATIC METHOD OF PREDICTING PROTEIN-STRUCTURE BY HOMOLOGY - AN EVALUATION OF SUBOPTIMAL SEQUENCE ALIGNMENTS, PROTEIN ENGINEERING, Vol: 5, Pages: 305-311, ISSN: 0269-2139

JOURNAL ARTICLE

STERNBERG MJE, LEWIS RA, KING RD, MUGGLETON Set al., 1992, MODELING THE STRUCTURE AND FUNCTION OF ENZYMES BY MACHINE LEARNING, FARADAY DISCUSSIONS, Vol: 93, Pages: 269-280, ISSN: 1359-6640

JOURNAL ARTICLE

Sternberg MJE, 1992, Secondary structure prediction. Current Opinion in Structural Biology 1992, 2:237-241, Current Opinion in Structural Biology, Vol: 2, Pages: 237-241, ISSN: 0959-440X

The prediction of protein secondary structure from sequence is routinely used whenever a new protein is cloned, and can be the first step in a tertiary structure prediction. This review summarizes the new methods that have been applied during the past year to this long-standing problem. The accuracy for a prediction of α-helices, β-sheets and coil remains at ∼65%. © 1992.

JOURNAL ARTICLE

WALLS PH, STERNBERG MJE, 1992, NEW ALGORITHM TO MODEL PROTEIN PROTEIN RECOGNITION BASED ON SURFACE COMPLEMENTARITY - APPLICATIONS TO ANTIBODY ANTIGEN DOCKING, JOURNAL OF MOLECULAR BIOLOGY, Vol: 228, Pages: 277-297, ISSN: 0022-2836

JOURNAL ARTICLE

HIRST JD, STERNBERG MJE, 1991, PREDICTION OF ATP-BINDING MOTIFS - A COMPARISON OF A PERCEPTRON-TYPE NEURAL NETWORK AND A CONSENSUS SEQUENCE METHOD, PROTEIN ENGINEERING, Vol: 4, Pages: 615-623, ISSN: 0269-2139

JOURNAL ARTICLE

Hirst JD, Sternberg MJ, 1991, Prediction of ATP/GTP-binding motif: a comparison of a perceptron type neural network and a consensus sequence method [corrected]., Protein Eng, Vol: 4, Pages: 615-623, ISSN: 0269-2139

Neural networks have been applied to a number of protein structure problems. In some applications their success has not been substantiated by a comparison with the performance of a suitable alternative statistical method on the same data. In this paper, a two-layer feed-forward neural network has been trained to recognize ATP/GTP-binding [corrected] local sequence motifs. The neural network correctly classified 78% of the 349 sequences used. This was much better than a simple motif-searching program. A more sophisticated statistical method was developed, however, which performed marginally better (80% correct classification) than the neural network. The neural network and the statistical method performed similarly on sequences of varying degrees of homology. These results do not imply that neural networks, especially those with hidden layers, are not useful tools, but they do suggest that two-layer networks in particular should be carefully tested against other statistical methods.

JOURNAL ARTICLE

ISLAM SA, WOLF CR, LENNARD MS, STERNBERG MJEet al., 1991, A 3-DIMENSIONAL MOLECULAR TEMPLATE FOR SUBSTRATES OF HUMAN CYTOCHROME-P450 INVOLVED IN DEBRISOQUINE 4-HYDROXYLATION, CARCINOGENESIS, Vol: 12, Pages: 2211-2219, ISSN: 0143-3334

JOURNAL ARTICLE

SAQI MAS, STERNBERG MJE, 1991, A SIMPLE METHOD TO GENERATE NONTRIVIAL ALTERNATE ALIGNMENTS OF PROTEIN SEQUENCES, JOURNAL OF MOLECULAR BIOLOGY, Vol: 219, Pages: 727-732, ISSN: 0022-2836

JOURNAL ARTICLE

STERNBERG MJE, 1991, PROMOT - A FORTRAN PROGRAM TO SCAN PROTEIN SEQUENCES AGAINST A LIBRARY OF KNOWN MOTIFS, COMPUTER APPLICATIONS IN THE BIOSCIENCES, Vol: 7, Pages: 257-260, ISSN: 0266-7061

JOURNAL ARTICLE

STERNBERG MJE, 1991, LIBRARY OF COMMON PROTEIN MOTIFS, NATURE, Vol: 349, Pages: 111-111, ISSN: 0028-0836

JOURNAL ARTICLE

STERNBERG MJE, ISLAM SA, 1991, PROTEIN SEQUENCES - HOMOLOGIES AND MOTIFS, TRENDS IN BIOTECHNOLOGY, Vol: 9, Pages: 300-302, ISSN: 0167-7799

JOURNAL ARTICLE

Sternberg MJ, 1991, Library of common protein motifs., Nature, Vol: 349, ISSN: 0028-0836

JOURNAL ARTICLE

ZVELEBIL MJJM, WOLF CR, STERNBERG MJE, 1991, A PREDICTED 3-DIMENSIONAL STRUCTURE OF HUMAN CYTOCHROME-P450 - IMPLICATIONS FOR SUBSTRATE-SPECIFICITY, PROTEIN ENGINEERING, Vol: 4, Pages: 271-282, ISSN: 0269-2139

JOURNAL ARTICLE

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