Imperial College London

ProfessorMichaelSternberg

Faculty of Natural SciencesDepartment of Life Sciences

Director Centre for Bioinformatics
 
 
 
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Contact

 

+44 (0)20 7594 5212m.sternberg Website

 
 
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Location

 

306Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ciezarek,
author = {Ciezarek, A and Osbourne, O and Shipley, ON and Brooks, EJ and Tracey, S and McAllister, J and Gardner, L and Sternberg, MJE and Block, B and Savolainen, V},
journal = {Molecular Biology and Evolution},
title = {Diversification of characteristics related to regional endothermy in Thunnus tunas},
url = {http://hdl.handle.net/10044/1/65244},
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Birds, mammals, and certain fishes, including tunas, opahs and lamnid sharks, are endothermic, conserving internally generated, metabolic heat to maintain body or tissue temperatures above that of the environment. Bluefin tunas, among the most threatened, but commercially important, fishes worldwide are renowned regional endotherms, maintaining elevated temperatures of the oxidative locomotor muscle, viscera, brain and eyes, and occupying cold, productive high-latitude waters. Less cold-tolerant tuna, such as yellowfin, by contrast, remain in warm-temperate to tropical waters year-round, reproducing more rapidly than temperate bluefin tuna. Thereby, they are more resilient to fisheries, whereas bluefins have declined steeply. Despite the importance of these traits to not only fisheries, but response to climate change, little is known of the genetic processes underlying the diversification of tuna. In collecting and analysing sequence data across 29,556 genes, we found that parallel selection on standing genetic variation has driven the evolution of endothermy in bluefin tunas. This includes two shared substitutions in genes encoding glycerol-3 phosphate dehydrogenase, an enzyme which underlies thermogenesis in bumblebees and mammals, as well as four genes involved in the Krebs cycle, oxidative phosphorylation, β-oxidation and superoxide removal. Using phylogenetic techniques, we further illustrate that the eight Thunnus species are genetically distinct, but found evidence of mitochondrial genome introgression across two species. Phylogeny-based metrics highlight conservation needs for some of these species.
AU - Ciezarek,A
AU - Osbourne,O
AU - Shipley,ON
AU - Brooks,EJ
AU - Tracey,S
AU - McAllister,J
AU - Gardner,L
AU - Sternberg,MJE
AU - Block,B
AU - Savolainen,V
SN - 1537-1719
TI - Diversification of characteristics related to regional endothermy in Thunnus tunas
T2 - Molecular Biology and Evolution
UR - http://hdl.handle.net/10044/1/65244
ER -