Imperial College London


Faculty of Natural SciencesDepartment of Life Sciences

Director Centre for Bioinformatics



+44 (0)20 7594 5212m.sternberg Website




306Sir Ernst Chain BuildingSouth Kensington Campus






BibTex format

author = {Barton, G and Abbott, J and Chiba, N and Huang, DW and Huang, Y and Krznaric, M and Mack, Smith J and Saleem, A and Sherman, BT and Tiwari, B and Tomlinson, CD and Aitman, T and Darlington, J and Game, L and Sternberg, MJE and Butcher, S},
doi = {10.1186/1471-2105-9-493},
journal = {BMC Bioinformatics},
title = {EMAAS: An extensible grid-based Rich Internet Application for microarray data analysis and management},
url = {},
volume = {9},
year = {2008}

RIS format (EndNote, RefMan)

AB - BackgroundMicroarray experimentation requires the application of complex analysis methods as well as the use of non-trivial computer technologies to manage the resultant large data sets. This, together with the proliferation of tools and techniques for microarray data analysis, makes it very challenging for a laboratory scientist to keep up-to-date with the latest developments in this field. Our aim was to develop a distributed e-support system for microarray data analysis and management.ResultsEMAAS (Extensible MicroArray Analysis System) is a multi-user rich internet application (RIA) providing simple, robust access to up-to-date resources for microarray data storage and analysis, combined with integrated tools to optimise real time user support and training. The system leverages the power of distributed computing to perform microarray analyses, and provides seamless access to resources located at various remote facilities. The EMAAS framework allows users to import microarray data from several sources to an underlying database, to pre-process, quality assess and analyse the data, to perform functional analyses, and to track data analysis steps, all through a single easy to use web portal. This interface offers distance support to users both in the form of video tutorials and via live screen feeds using the web conferencing tool EVO. A number of analysis packages, including R-Bioconductor and Affymetrix Power Tools have been integrated on the server side and are available programmatically through the Postgres-PLR library or on grid compute clusters. Integrated distributed resources include the functional annotation tool DAVID, GeneCards and the microarray data repositories GEO, CELSIUS and MiMiR. EMAAS currently supports analysis of Affymetrix 3' and Exon expression arrays, and the system is extensible to cater for other microarray and transcriptomic platforms.ConclusionEMAAS enables users to track and perform microarray data management and analysis tasks through
AU - Barton,G
AU - Abbott,J
AU - Chiba,N
AU - Huang,DW
AU - Huang,Y
AU - Krznaric,M
AU - Mack,Smith J
AU - Saleem,A
AU - Sherman,BT
AU - Tiwari,B
AU - Tomlinson,CD
AU - Aitman,T
AU - Darlington,J
AU - Game,L
AU - Sternberg,MJE
AU - Butcher,S
DO - 10.1186/1471-2105-9-493
PY - 2008///
SN - 1471-2105
TI - EMAAS: An extensible grid-based Rich Internet Application for microarray data analysis and management
T2 - BMC Bioinformatics
UR -
UR -
VL - 9
ER -