Imperial College London

ProfessorMichaelSternberg

Faculty of Natural SciencesDepartment of Life Sciences

Director Centre for Bioinformatics
 
 
 
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Contact

 

+44 (0)20 7594 5212m.sternberg Website

 
 
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Location

 

306Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lewis:2013:nar/gks1266,
author = {Lewis, TE and Sillitoe, I and Andreeva, A and Blundell, TL and Buchan, DW and Chothia, C and Cuff, A and Dana, JM and Filippis, I and Gough, J and Hunter, S and Jones, DT and Kelley, LA and Kleywegt, GJ and Minneci, F and Mitchell, A and Murzin, AG and Ochoa-Montano, B and Rackham, OJ and Smith, J and Sternberg, MJ and Velankar, S and Yeats, C and Orengo, C},
doi = {nar/gks1266},
journal = {Nucleic Acids Res},
pages = {D499--D507},
title = {Genome3D: a UK collaborative project to annotate genomic sequences with predicted 3D structures based on SCOP and CATH domains},
url = {http://dx.doi.org/10.1093/nar/gks1266},
volume = {41},
year = {2013}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Genome3D, available at http://www.genome3d.eu, is a new collaborative project that integrates UK-based structural resources to provide a unique perspective on sequence-structure-function relationships. Leading structure prediction resources (DomSerf, FUGUE, Gene3D, pDomTHREADER, Phyre and SUPERFAMILY) provide annotations for UniProt sequences to indicate the locations of structural domains (structural annotations) and their 3D structures (structural models). Structural annotations and 3D model predictions are currently available for three model genomes (Homo sapiens, E. coli and baker's yeast), and the project will extend to other genomes in the near future. As these resources exploit different strategies for predicting structures, the main aim of Genome3D is to enable comparisons between all the resources so that biologists can see where predictions agree and are therefore more trusted. Furthermore, as these methods differ in whether they build their predictions using CATH or SCOP, Genome3D also contains the first official mapping between these two databases. This has identified pairs of similar superfamilies from the two resources at various degrees of consensus (532 bronze pairs, 527 silver pairs and 370 gold pairs).
AU - Lewis,TE
AU - Sillitoe,I
AU - Andreeva,A
AU - Blundell,TL
AU - Buchan,DW
AU - Chothia,C
AU - Cuff,A
AU - Dana,JM
AU - Filippis,I
AU - Gough,J
AU - Hunter,S
AU - Jones,DT
AU - Kelley,LA
AU - Kleywegt,GJ
AU - Minneci,F
AU - Mitchell,A
AU - Murzin,AG
AU - Ochoa-Montano,B
AU - Rackham,OJ
AU - Smith,J
AU - Sternberg,MJ
AU - Velankar,S
AU - Yeats,C
AU - Orengo,C
DO - nar/gks1266
EP - 507
PY - 2013///
SN - 1362-4962
SP - 499
TI - Genome3D: a UK collaborative project to annotate genomic sequences with predicted 3D structures based on SCOP and CATH domains
T2 - Nucleic Acids Res
UR - http://dx.doi.org/10.1093/nar/gks1266
UR - http://www.ncbi.nlm.nih.gov/pubmed/23203986
UR - http://hdl.handle.net/10044/1/56809
VL - 41
ER -