Imperial College London


Faculty of Natural SciencesDepartment of Life Sciences

Director Centre for Bioinformatics



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BibTex format

author = {Greener, J and sternberg, MJE},
doi = {10.1016/},
journal = {Current Opinion in Structural Biology},
pages = {1--8},
title = {Structure-based prediction of protein allostery},
url = {},
volume = {50},
year = {2017}

RIS format (EndNote, RefMan)

AB - Allostery is the functional change at one site on a protein caused by a change at a distant site. In order for the benefits of allostery to be taken advantage of, both for basic understanding of proteins and to develop new classes of drugs, the structure-based prediction of allosteric binding sites, modulators and communication pathways is necessary. Here we review the recently emerging field of allosteric prediction, focusing mainly on computational methods. We also describe the search for cryptic binding pockets and attempts to design allostery into proteins. The development and adoption of such methods is essential or the long-preached potential of allostery will remain elusive.
AU - Greener,J
AU - sternberg,MJE
DO - 10.1016/
EP - 8
PY - 2017///
SN - 0959-440X
SP - 1
TI - Structure-based prediction of protein allostery
T2 - Current Opinion in Structural Biology
UR -
UR -
VL - 50
ER -