Imperial College London
Alternate

ProfessorMichaelSternberg

Faculty of Natural Sciences, Department of Life Sciences

Director, Systems Biology and Bioinformatics Centre
 
 
 
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Contact

 

+44 (0)20 7594 5212m.sternberg Website

 
 
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Location

 

306Sir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Howard:2016:10.15252/emmm.201606250,
author = {Howard, SR and Guasti, L and Ruiz-Babot, G and Mancini, A and David, A and Storr, HL and Metherell, LA and Sternberg, MJ and Cabrera, CP and Warren, HR and Barnes, MR and Quinton, R and de, Roux N and Young, J and Guiochon-Mantel, A and Wehkalampi, K and André, V and Gothilf, Y and Cariboni, A and Dunkel, L},
doi = {10.15252/emmm.201606250},
journal = {EMBO Molecular Medicine},
pages = {626--642},
title = {IGSF10 mutations dysregulate gonadotropin-releasing hormone neuronal migration resulting in delayed puberty.},
url = {http://dx.doi.org/10.15252/emmm.201606250},
volume = {8},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Early or late pubertal onset affects up to 5% of adolescents and is associated with adverse health and psychosocial outcomes. Self-limited delayed puberty (DP) segregates predominantly in an autosomal dominant pattern, but the underlying genetic background is unknown. Using exome and candidate gene sequencing, we have identified rare mutations in IGSF10 in 6 unrelated families, which resulted in intracellular retention with failure in the secretion of mutant proteins. IGSF10 mRNA was strongly expressed in embryonic nasal mesenchyme, during gonadotropin-releasing hormone (GnRH) neuronal migration to the hypothalamus. IGSF10 knockdown caused a reduced migration of immature GnRH neurons in vitro, and perturbed migration and extension of GnRH neurons in a gnrh3:EGFP zebrafish model. Additionally, loss-of-function mutations in IGSF10 were identified in hypothalamic amenorrhea patients. Our evidence strongly suggests that mutations in IGSF10 cause DP in humans, and points to a common genetic basis for conditions of functional hypogonadotropic hypogonadism (HH). While dysregulation of GnRH neuronal migration is known to cause permanent HH, this is the first time that this has been demonstrated as a casual mechanism in DP.
AU  - Howard,SR
AU  - Guasti,L
AU  - Ruiz-Babot,G
AU  - Mancini,A
AU  - David,A
AU  - Storr,HL
AU  - Metherell,LA
AU  - Sternberg,MJ
AU  - Cabrera,CP
AU  - Warren,HR
AU  - Barnes,MR
AU  - Quinton,R
AU  - de,Roux N
AU  - Young,J
AU  - Guiochon-Mantel,A
AU  - Wehkalampi,K
AU  - André,V
AU  - Gothilf,Y
AU  - Cariboni,A
AU  - Dunkel,L
DO  - 10.15252/emmm.201606250
EP  - 642
PY  - 2016///
SN  - 1757-4676
SP  - 626
TI  - IGSF10 mutations dysregulate gonadotropin-releasing hormone neuronal migration resulting in delayed puberty.
T2  - EMBO Molecular Medicine
UR  - http://dx.doi.org/10.15252/emmm.201606250
UR  - http://hdl.handle.net/10044/1/32398
VL  - 8
ER  -
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