Imperial College London

Professor Molly Stevens FREng

Faculty of EngineeringDepartment of Materials

Prof of Biomedical Materials&Regenerative Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6804m.stevens

 
 
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Location

 

208Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

350 results found

Poologasundarampillai G, Yu B, Tsigkou O, Valliant E, Yue S, Lee PD, Hamilton RW, Stevens MM, Kasuga T, Jones JRet al., 2012, Bioactive silica-poly(gamma-glutamic acid) hybrids for bone regeneration: effect of covalent coupling on dissolution and mechanical properties and fabrication of porous scaffolds, SOFT MATTER, Vol: 8, Pages: 4822-4832, ISSN: 1744-683X

Journal article

Lowe SB, Dick JAG, Cohen BE, Stevens MMet al., 2012, Multiplex Sensing of Protease and Kinase Enzyme Activity via Orthogonal Coupling of Quantum Dot Peptide Conjugates, ACS NANO, Vol: 6, Pages: 851-857, ISSN: 1936-0851

Journal article

Ji L, LaPointe VLS, Evans ND, Stevens MMet al., 2012, CHANGES IN EMBRYONIC STEM CELL COLONY MORPHOLOGY AND EARLY DIFFERENTIATION MARKERS DRIVEN BY COLLOIDAL CRYSTAL TOPOGRAPHICAL CUES, EUROPEAN CELLS & MATERIALS, Vol: 23, Pages: 135-146, ISSN: 1473-2262

Journal article

Howitt P, Darzi A, Yang GZ, Ashrafian H, Atun R, Barlow J, Blakemore A, Bull AMJ, Car J, Conteh L, Cooke GS, Ford N, Gregson SAJ, Kerr K, King D, Kulendran M, Malkin RA, Majeed A, Matlin S, Merrifield R, Penfold HA, Reid SD, Smith PC, Stevens MM, Templeton MR, Vincent C, Wilson Eet al., 2012, Technologies for global health, The Lancet, Vol: 380, Pages: 507-535

Journal article

Tierney HL, Bonnell DA, Buriak JM, Hafner JH, Hammond PT, Hersam MC, Javey A, Kotov NA, Nordlander P, Parak WJ, Rogach AL, Schaak RE, Stevens MM, Wee ATS, Willson CG, Weiss PSet al., 2011, ACS nano in 2011 and looking forward to 2012, ACS Nano, Vol: 5, Pages: 9301-9302, ISSN: 1936-0851

Journal article

Aili D, Gryko P, Sepulveda B, Dick JAG, Kirby N, Heenan R, Baltzer L, Liedberg B, Ryan MP, Stevens MMet al., 2011, Polypeptide Folding-Mediated Tuning of the Optical and Structural Properties of Gold Nanoparticle Assemblies, NANO LETTERS, Vol: 11, Pages: 5564-5573, ISSN: 1530-6984

Journal article

Place ES, Rojo L, Gentleman E, Sardinha JP, Stevens MMet al., 2011, Strontium- and Zinc-Alginate Hydrogels for Bone Tissue Engineering, TISSUE ENGINEERING PART A, Vol: 17, Pages: 2713-2722, ISSN: 1937-3341

Journal article

Ball MD, Bonzani IC, Bovis MJ, Williams A, Stevens MMet al., 2011, Human Periosteum Is a Source of Cells for Orthopaedic Tissue Engineering: A Pilot Study, CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, Vol: 469, Pages: 3085-3093, ISSN: 0009-921X

Journal article

McCullen SD, Chow AGY, Stevens MM, 2011, In vivo tissue engineering of musculoskeletal tissues, CURRENT OPINION IN BIOTECHNOLOGY, Vol: 22, Pages: 715-720, ISSN: 0958-1669

Journal article

Clarke DE, McCullen SD, Chow AGY, Stevens MMet al., 2011, Functional Biomaterials, Comprehensive Biotechnology, Second Edition, Pages: 3-10, ISBN: 9780444533524

© 2011 Elsevier B.V. All rights reserved. The field of biomaterials is a multidisciplinary, exciting, and constantly evolving area of research. Materials have been used for thousands of years to aid the practice of medicine and help repair the human body to overcome both disease and injury. Currently, the use of materials in medicine is expansive, with a vast library of established metals, ceramics, and polymeric materials in clinical use. The materials serve applications from simple sutures and dental implants, to limb and ocular prostheses, to even highly complex engineered devices such as left ventricular assist devices. In the constantly evolving field of biomaterials, there has been a paradigm shift toward the development of functional materials by designing for desired cellular and mechanical response. In this article, we discuss currently used biomaterials, explore how materials can be designed and engineered to interact and respond to their mechanical and biological environments, and present the development of new design and fabrication techniques to mimic the mechanical response of complex tissues.

Book chapter

Mager MD, LaPointe V, Stevens MM, 2011, Exploring and exploiting chemistry at the cell surface, NATURE CHEMISTRY, Vol: 3, Pages: 582-589, ISSN: 1755-4330

Journal article

Brauer DS, Gentleman E, Farrar DF, Stevens MM, Hill RGet al., 2011, Benefits and drawbacks of zinc in glass ionomer bone cements, BIOMEDICAL MATERIALS, Vol: 6, ISSN: 1748-6041

Journal article

Lim EH, Sardinha JP, Shefelbine S, Myers SR, Stevens MMet al., 2011, State-of-the-Art Smart Biomimetic Scaffold for Cartilage Regeneration: In-vitro and In-vivo Studies, Annual Meeting of the Society-of-Academic-and-Research-Surgeons, Publisher: WILEY-BLACKWELL, Pages: E11-E11, ISSN: 0007-1323

Conference paper

Bertazzo S, Cloyd KL, Gentleman E, El-Hamamsy I, Chester AH, Yacoub MH, Stevens MMet al., 2011, NANO- AND MICRO-STRUCTURE OF CALCIFICATION IN HUMAN AORTIC VALVE, AORTA AND CORONARY WALL, 79th Congress of the European-Atherosclerosis-Society (EAS), Publisher: ELSEVIER IRELAND LTD, Pages: 62-62, ISSN: 1567-5688

Conference paper

Aili D, Mager M, Roche D, Stevens MMet al., 2011, Hybrid Nanoparticle-Liposome Detection of Phospholipase Activity, NANO LETTERS, Vol: 11, Pages: 1401-1405, ISSN: 1530-6984

Journal article

Hung A, Mwenifumbo S, Mager M, Kuna JJ, Stellacci F, Yarovsky I, Stevens MMet al., 2011, Ordering Surfaces on the Nanoscale: Implications for Protein Adsorption, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol: 133, Pages: 1438-1450, ISSN: 0002-7863

Journal article

Stevens MM, 2011, Exploring and Engineering the Cell-Surface Interface, 55th Annual Meeting of the Biophysical-Society, Publisher: CELL PRESS, Pages: 189-189, ISSN: 0006-3495

Conference paper

Labbaf S, Tsigkou O, Mueller KH, Stevens MM, Porter AE, Jones JRet al., 2011, Spherical bioactive glass particles and their interaction with human mesenchymal stem cells in vitro, BIOMATERIALS, Vol: 32, Pages: 1010-1018, ISSN: 0142-9612

Journal article

Vanleene M, Saldanha Z, Cloyd KL, Jell G, Bou-Gharios G, Bassett JH, Williams GR, Fisk NM, Oyen ML, Stevens MM, Shefelbine SJ, Guillot PVet al., 2011, Transplantation of human fetal blood stem cells in the osteogenesis imperfecta mouse leads to improvement in multiscale tissue properties., Blood, Vol: 117, Pages: 1053-1060

Osteogenesis imperfecta (OI or brittle bone disease) is a disorder of connective tissues caused by mutations in the collagen genes. We previously showed that intrauterine transplantation of human blood fetal stem/stromal cells in OI mice (oim) resulted in a significant reduction of bone fracture. This work examines the cellular mechanisms and mechanical bone modifications underlying these therapeutic effects, particularly examining the direct effects of donor collagen expression on bone material properties. In this study, we found an 84% reduction in femoral fractures in transplanted oim mice. Fetal blood stem/stromal cells engrafted in bones, differentiated into mature osteoblasts, expressed osteocalcin, and produced COL1a2 protein, which is absent in oim mice. The presence of normal collagen decreased hydroxyproline content in bones, altered the apatite crystal structure, increased the bone matrix stiffness, and reduced bone brittleness. In conclusion, expression of normal collagen from mature osteoblast of donor origin significantly decreased bone brittleness by improving the mechanical integrity of the bone at the molecular, tissue, and whole bone levels.

Journal article

Ji L, Jell G, Dong Y, Jones JR, Stevens MMet al., 2011, Template synthesis of ordered macroporous hydroxyapatite bioceramics, CHEMICAL COMMUNICATIONS, Vol: 47, Pages: 9048-9050, ISSN: 1359-7345

Journal article

Gupta S, Andresen H, Stevens MM, 2011, Single-step kinase inhibitor screening using a peptide-modified gold nanoparticle platform, CHEMICAL COMMUNICATIONS, Vol: 47, Pages: 2249-2251, ISSN: 1359-7345

Journal article

Ghadiali JE, Lowe SB, Stevens MM, 2011, Quantum-Dot-Based FRET Detection of Histone Acetyltransferase Activity, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 50, Pages: 3417-3420, ISSN: 1433-7851

Journal article

Andresen H, Gupta S, Stevens MM, 2011, Kinetic investigation of bioresponsive nanoparticle assembly as a function of ligand design, NANOSCALE, Vol: 3, Pages: 383-386, ISSN: 2040-3364

Journal article

Woodward RT, Hight C, Yildiz U, Schaeffer N, Valliant EM, Jones JR, Stevens MM, Weaver JVMet al., 2011, Reversible aggregation of responsive polymer-stabilized colloids and the pH-dependent formation of porous scaffolds, SOFT MATTER, Vol: 7, Pages: 7560-7566, ISSN: 1744-683X

Journal article

Basey-Fisher TH, Hanham SM, Andresen H, Maier SA, Stevens MM, Alford NM, Klein Net al., 2011, Microwave Debye relaxation analysis of dissolved proteins: Towards free-solution biosensing, Applied Physics Letters, Vol: 99, Pages: 233703-233703

Journal article

Mahony O, Tsigkou O, Ionescu C, Minelli C, Ling L, Hanly R, Smith ME, Stevens MM, Jones JRet al., 2010, Silica-Gelatin Hybrids with Tailorable Degradation and Mechanical Properties for Tissue Regeneration, ADVANCED FUNCTIONAL MATERIALS, Vol: 20, Pages: 3835-3845, ISSN: 1616-301X

Journal article

Minelli C, Lowe SB, Stevens MM, 2010, Engineering Nanocomposite Materials for Cancer Therapy, SMALL, Vol: 6, Pages: 2336-2357, ISSN: 1613-6810

Journal article

Stevens MM, Khademhosseini A, 2010, Emerging materials for tissue engineering and regenerative medicine: Themed issue for Journal of Materials Chemistry and Soft Matter, Journal of Materials Chemistry, Vol: 20, ISSN: 0959-9428

Journal article

Stevens MM, Khademhosseini A, 2010, Emerging materials for tissue engineering and regenerative medicine: Themed issue for soft matter and journal of materials chemistry, Soft Matter, Vol: 6, ISSN: 1744-683X

Journal article

Tang M, Dong Y, Stevens MM, Williams CKet al., 2010, Tailoring Polylactide Degradation: Copolymerization of a Carbohydrate Lactone and S,S-Lactide, Macromolecules, Vol: 43, Pages: 7556-7564, ISSN: 0024-9297

Journal article

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