Imperial College London

Professor Molly Stevens FREng

Faculty of EngineeringDepartment of Materials

Prof of Biomedical Materials&Regenerative Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6804m.stevens

 
 
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Location

 

208Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Li:2018:10.1016/j.biomaterials.2018.05.029,
author = {Li, C and Armstrong, J and Pence, I and Kit-Anan, W and Puetzer, J and Correia, Carreira S and Stevens, MM},
doi = {10.1016/j.biomaterials.2018.05.029},
journal = {Biomaterials},
pages = {24--33},
title = {Glycosylated superparamagnetic nanoparticle gradients for osteochondral tissue engineering},
url = {http://dx.doi.org/10.1016/j.biomaterials.2018.05.029},
volume = {176},
year = {2018}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - In developmental biology, gradients of bioactive signals direct the formation of structural transitions in tissue that are key to physiological function. Failure to reproduce these native features in an in vitro setting can severely limit the success of bioengineered tissue constructs. In this report, we introduce a facile and rapid platform that uses magnetic field alignment of glycosylated superparamagnetic iron oxide nanoparticles, pre-loaded with growth factors, to pattern biochemical gradients into a range of biomaterial systems. Gradients of bone morphogenetic protein 2 in agarose hydrogels were used to spatially direct the osteogenesis of human mesenchymal stem cells and generate robust osteochondral tissue constructs exhibiting a clear mineral transition from bone to cartilage. Interestingly, the smooth gradients in growth factor concentration gave rise to biologically-relevant, emergent structural features, including a tidemark transition demarcating mineralized and non-mineralized tissue and an osteochondral interface rich in hypertrophic chondrocytes. This platform technology offers great versatility and provides an exciting new opportunity for overcoming a range of interfacial tissue engineering challenges.
AU - Li,C
AU - Armstrong,J
AU - Pence,I
AU - Kit-Anan,W
AU - Puetzer,J
AU - Correia,Carreira S
AU - Stevens,MM
DO - 10.1016/j.biomaterials.2018.05.029
EP - 33
PY - 2018///
SN - 0142-9612
SP - 24
TI - Glycosylated superparamagnetic nanoparticle gradients for osteochondral tissue engineering
T2 - Biomaterials
UR - http://dx.doi.org/10.1016/j.biomaterials.2018.05.029
UR - http://hdl.handle.net/10044/1/60242
VL - 176
ER -