Imperial College London

Professor Molly Stevens FREng

Faculty of EngineeringDepartment of Materials

Prof of Biomedical Materials&Regenerative Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6804m.stevens

 
 
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Location

 

208Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lin:2019:10.1039/C8SC04725A,
author = {Lin, Y and Mazo, M and Skaalure, S and Thomas, MR and Schultz, SR and Stevens, M},
doi = {10.1039/C8SC04725A},
journal = {Chemical Science},
pages = {1158--1167},
title = {Activatable cell-biomaterial interfacing with photo-caged peptides},
url = {http://dx.doi.org/10.1039/C8SC04725A},
volume = {10},
year = {2019}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Spatio-temporally tailoring cell–material interactions is essential for developing smart delivery systems and intelligent biointerfaces. Here we report new photo-activatable cell–material interfacing systems that trigger cellular uptake of various cargoes and cell adhesion towards surfaces. To achieve this, we designed a novel photo-caged peptide which undergoes a structural transition from an antifouling ligand to a cell-penetrating peptide upon photo-irradiation. When the peptide is conjugated to ligands of interest, we demonstrate the photo-activated cellular uptake of a wide range of cargoes, including small fluorophores, proteins, inorganic (e.g., quantum dots and gold nanostars) and organic nanomaterials (e.g., polymeric particles), and liposomes. Using this system, we can remotely regulate drug administration into cancer cells by functionalizing camptothecin-loaded polymeric nanoparticles with our synthetic peptide ligands. Furthermore, we show light-controlled cell adhesion on a peptide-modified surface and 3D spatiotemporal control over cellular uptake of nanoparticles using two-photon excitation. We anticipate that the innovative approach proposed in this work will help to establish new stimuli-responsive delivery systems and biomaterials.
AU - Lin,Y
AU - Mazo,M
AU - Skaalure,S
AU - Thomas,MR
AU - Schultz,SR
AU - Stevens,M
DO - 10.1039/C8SC04725A
EP - 1167
PY - 2019///
SN - 2041-6520
SP - 1158
TI - Activatable cell-biomaterial interfacing with photo-caged peptides
T2 - Chemical Science
UR - http://dx.doi.org/10.1039/C8SC04725A
UR - http://hdl.handle.net/10044/1/66279
VL - 10
ER -