Imperial College London

Professor Molly Stevens

Faculty of EngineeringDepartment of Materials

Professor of Biomedical Materials and Regenerative Medicine



+44 (0)20 7594 6804m.stevens




208Royal School of MinesSouth Kensington Campus






BibTex format

author = {Pujari-Palmer, M and Guo, H and Wenner, D and Autefage, H and Spicer, CD and Stevens, MM and Omar, O and Thomsen, P and Eden, M and Insley, G and Procter, P and Engqvist, H},
doi = {10.3390/ma11122492},
journal = {Materials},
title = {A novel class of injectable bioceramics that glue tissues and biomaterials},
url = {},
volume = {11},
year = {2018}

RIS format (EndNote, RefMan)

AB - Calcium phosphate cements (CPCs) are clinically effective void fillers that are capable of bridging calcified tissue defects and facilitating regeneration. However, CPCs are completely synthetic/inorganic, unlike the calcium phosphate that is found in calcified tissues, and they lack an architectural organization, controlled assembly mechanisms, and have moderate biomechanical strength, which limits their clinical effectiveness. Herein, we describe a new class of bioinspired CPCs that can glue tissues together and bond tissues to metallic and polymeric biomaterials. Surprisingly, alpha tricalcium phosphate cements that are modified with simple phosphorylated amino acid monomers of phosphoserine (PM-CPCs) bond tissues up to 40-fold stronger (2.5–4 MPa) than commercial cyanoacrylates (0.1 MPa), and 100-fold stronger than surgical fibrin glue (0.04 MPa), when cured in wet-field conditions. In addition to adhesion, phosphoserine creates other novel properties in bioceramics, including a nanoscale organic/inorganic composite microstructure, and templating of nanoscale amorphous calcium phosphate nucleation. PM-CPCs are made of the biocompatible precursors calcium, phosphate, and amino acid, and these represent the first amorphous nano-ceramic composites that are stable in liquids.
AU - Pujari-Palmer,M
AU - Guo,H
AU - Wenner,D
AU - Autefage,H
AU - Spicer,CD
AU - Stevens,MM
AU - Omar,O
AU - Thomsen,P
AU - Eden,M
AU - Insley,G
AU - Procter,P
AU - Engqvist,H
DO - 10.3390/ma11122492
PY - 2018///
SN - 1996-1944
TI - A novel class of injectable bioceramics that glue tissues and biomaterials
T2 - Materials
UR -
UR -
UR -
VL - 11
ER -