Imperial College London

Professor Molly Stevens FREng

Faculty of EngineeringDepartment of Materials

Prof of Biomedical Materials&Regenerative Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6804m.stevens

 
 
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Location

 

208Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Paxton:2019:10.1002/marc.201900019,
author = {Paxton, NC and Ren, J and Ainsworth, MJ and Solanki, AK and Jones, JR and Allenby, MC and Stevens, M and Woodruff, MA},
doi = {10.1002/marc.201900019},
journal = {Macromolecular Rapid Communications},
title = {Rheological characterization of biomaterials directs additive manufacturing of strontium-substituted bioactive Gglass/polycaprolactone microfibers},
url = {http://dx.doi.org/10.1002/marc.201900019},
year = {2019}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Additive manufacturing via melt electrowriting (MEW) can create ordered microfiber scaffolds relevant for bone tissue engineering; however, there remain limitations in the adoption of new printing materials, especially in MEW of biomaterials. For example, while promising composite formulations of polycaprolactone with strontiumsubstituted bioactive glass have been processed into large or disordered fibres, from what is known, biologicallyrelevant concentrations (>10 wt%) have never been printed into ordered microfibers using MEW. In this study, rheological characterization is used in combination with a predictive mathematical model to optimize biomaterial formulations and MEW conditions required to extrude various PCL and PCL/SrBG biomaterials to create ordered scaffolds. Previously, MEW printing of PCL/SrBG composites with 33 wt% glass required unachievable extrusion pressures. The composite formulation is modified using an evaporable solvent to reduce viscosity 100fold to fall within the predicted MEW pressure, temperature, and voltage tolerances, which enabled printing. This study reports the first fabrication of reproducible, ordered highcontent bioactive glass microfiber scaffolds by applying predictive modeling.
AU - Paxton,NC
AU - Ren,J
AU - Ainsworth,MJ
AU - Solanki,AK
AU - Jones,JR
AU - Allenby,MC
AU - Stevens,M
AU - Woodruff,MA
DO - 10.1002/marc.201900019
PY - 2019///
SN - 1022-1336
TI - Rheological characterization of biomaterials directs additive manufacturing of strontium-substituted bioactive Gglass/polycaprolactone microfibers
T2 - Macromolecular Rapid Communications
UR - http://dx.doi.org/10.1002/marc.201900019
UR - http://hdl.handle.net/10044/1/69118
ER -