Imperial College London

Professor Molly Stevens FREng

Faculty of EngineeringDepartment of Materials

Prof of Biomedical Materials&Regenerative Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6804m.stevens

 
 
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Location

 

208Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kim:2019:10.1016/j.jconrel.2019.04.003,
author = {Kim, H and Park, Y and Stevens, MM and Kwon, W and Hahn, SK},
doi = {10.1016/j.jconrel.2019.04.003},
journal = {Journal of Controlled Release},
pages = {55--66},
title = {Multifunctional hyaluronate - nanoparticle hybrid systems for diagnostic, therapeutic and theranostic applications},
url = {http://dx.doi.org/10.1016/j.jconrel.2019.04.003},
volume = {303},
year = {2019}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Diagnostic and therapeutic nanoparticles have been actively investigated for the last few decades as new platforms for biomedical applications. Despite their great versatility and potency, nanoparticles have generally required further modification with biocompatible materials such as biopolymers and synthetic polymers for in vivo administration to improve their biological functions, stability, and biocompatibility. Among a variety of natural and synthetic biomaterials, hyaluronate (HA) has been considered a promising biomolecule with which to construct nanohybrid systems, as it can enable long-term and efficient delivery of nanoparticles to target sites as well as physiological stabilization of nanoparticles by forming hydrophilic shells. In this review, we first describe various kinds of HA derivatives and their interactions with nanoparticles, and discuss how to design and develop optimal HA-nanoparticle hybrid systems for biomedical applications. Furthermore, we show several exemplary applications of HA-nanoparticle hybrid systems and provide our perspectives to their futuristic translational applications.
AU - Kim,H
AU - Park,Y
AU - Stevens,MM
AU - Kwon,W
AU - Hahn,SK
DO - 10.1016/j.jconrel.2019.04.003
EP - 66
PY - 2019///
SN - 0168-3659
SP - 55
TI - Multifunctional hyaluronate - nanoparticle hybrid systems for diagnostic, therapeutic and theranostic applications
T2 - Journal of Controlled Release
UR - http://dx.doi.org/10.1016/j.jconrel.2019.04.003
UR - https://www.ncbi.nlm.nih.gov/pubmed/30954619
UR - http://hdl.handle.net/10044/1/70071
VL - 303
ER -