Imperial College London

Professor Molly Stevens FREng

Faculty of EngineeringDepartment of Materials

Prof of Biomedical Materials&Regenerative Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6804m.stevens

 
 
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Location

 

208Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Howes:2014:10.1126/science.1247390,
author = {Howes, PD and Chandrawati, R and Stevens, MM},
doi = {10.1126/science.1247390},
journal = {Science},
title = {Colloidal nanoparticles as advanced biological sensors},
url = {http://dx.doi.org/10.1126/science.1247390},
volume = {346},
year = {2014}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Colloidal nanoparticle biosensors have received intense scientific attention and offer promising applications in both research and medicine. We review the state of the art in nanoparticle development, surface chemistry, and biosensing mechanisms, discussing how a range of technologies are contributing toward commercial and clinical translation. Recent examples of success include the ultrasensitive detection of cancer biomarkers in human serum and in vivo sensing of methyl mercury. We identify five key materials challenges, including the development of robust mass-scale nanoparticle synthesis methods, and five broader challenges, including the use of simulations and bioinformatics-driven experimental approaches for predictive modeling of biosensor performance. The resultant generation of nanoparticle biosensors will form the basis of high-performance analytical assays, effective multiplexed intracellular sensors, and sophisticated in vivo probes.
AU - Howes,PD
AU - Chandrawati,R
AU - Stevens,MM
DO - 10.1126/science.1247390
PY - 2014///
SN - 0036-8075
TI - Colloidal nanoparticles as advanced biological sensors
T2 - Science
UR - http://dx.doi.org/10.1126/science.1247390
UR - http://www.ncbi.nlm.nih.gov/pubmed/25278614
UR - http://hdl.handle.net/10044/1/21979
VL - 346
ER -