Imperial College London

Professor Molly Stevens FREng

Faculty of EngineeringDepartment of Materials

Prof of Biomedical Materials&Regenerative Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6804m.stevens

 
 
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Location

 

208Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hembury:2015:10.1073/pnas.1419622112,
author = {Hembury, M and Chiappini, C and Bertazzo, S and Kalber, TL and Drisko, GL and Ogunlade, O and Walker-Samuel, S and Krishna, KS and Jumeaux, C and Beard, P and Kumar, CSSR and Porter, AE and Lythgoe, MF and Boissiere, C and Sanchez, C and Stevens, MM},
doi = {10.1073/pnas.1419622112},
journal = {Proceedings of the National Academy of Sciences},
pages = {1959--1964},
title = {Gold-silica quantum rattles for multimodal imaging and therapy},
url = {http://dx.doi.org/10.1073/pnas.1419622112},
volume = {112},
year = {2015}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Gold quantum dots exhibit distinctive optical and magnetic behaviors compared with larger gold nanoparticles. However, their unfavorable interaction with living systems and lack of stability in aqueous solvents has so far prevented their adoption in biology and medicine. Here, a simple synthetic pathway integrates gold quantum dots within a mesoporous silica shell, alongside larger gold nanoparticles within the shell’s central cavity. This “quantum rattle” structure is stable in aqueous solutions, does not elicit cell toxicity, preserves the attractive near-infrared photonics and paramagnetism of gold quantum dots, and enhances the drug-carrier performance of the silica shell. In vivo, the quantum rattles reduced tumor burden in a single course of photothermal therapy while coupling three complementary imaging modalities: near-infrared fluorescence, photoacoustic, and magnetic resonance imaging. The incorporation of gold within the quantum rattles significantly enhanced the drug-carrier performance of the silica shell. This innovative material design based on the mutually beneficial interaction of gold and silica introduces the use of gold quantum dots for imaging and therapeutic applications.
AU - Hembury,M
AU - Chiappini,C
AU - Bertazzo,S
AU - Kalber,TL
AU - Drisko,GL
AU - Ogunlade,O
AU - Walker-Samuel,S
AU - Krishna,KS
AU - Jumeaux,C
AU - Beard,P
AU - Kumar,CSSR
AU - Porter,AE
AU - Lythgoe,MF
AU - Boissiere,C
AU - Sanchez,C
AU - Stevens,MM
DO - 10.1073/pnas.1419622112
EP - 1964
PY - 2015///
SN - 1091-6490
SP - 1959
TI - Gold-silica quantum rattles for multimodal imaging and therapy
T2 - Proceedings of the National Academy of Sciences
UR - http://dx.doi.org/10.1073/pnas.1419622112
UR - http://hdl.handle.net/10044/1/45488
VL - 112
ER -