Imperial College London

Professor Molly Stevens FREng

Faculty of EngineeringDepartment of Materials

Prof of Biomedical Materials&Regenerative Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6804m.stevens

 
 
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Location

 

208Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Fuhrmann:2015:10.1016/j.nantod.2015.04.004,
author = {Fuhrmann, G and Herrman, IK and Stevens, MM},
doi = {10.1016/j.nantod.2015.04.004},
journal = {Nano Today},
pages = {397--409},
title = {Cell-derived vesicles for drug therapy and diagnostics: Opportunities and challenges},
url = {http://dx.doi.org/10.1016/j.nantod.2015.04.004},
volume = {10},
year = {2015}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Extracellular vesicles are small lipid-based membrane-bound entities shed by cells under both physiological and pathological conditions. Their discovery as intercellular communicators through transfer of nucleic acid- and protein-based cargos between cells locally and at distance in a highly specific manner has created recent excitement. The information they transport and their composition may vary depending on the cell of origin as well as the eliciting stimulus. Such sensitive changes in vesicle characteristics hold significant promise for the improved diagnosis of pathological conditions, including infections and neoplastic lesions in a minimally invasive way. Similarly, these cell-derived vesicles exhibit promising characteristics that could enhance drug targeting efficiencies. Recent developments in the field have aimed at studying EVs as novel drug carriers due to their natural composition, biological function and selective cell interaction. In this review, we discuss new research avenues in diagnostics and drug therapy based on extracellular vesicles. We show how cell-derived vesicles can be harvested and engineered to meet application-specific design requirements. We finally discuss potential risks encountered when translating extracellular vesicle based approaches into (pre)clinical applications.
AU - Fuhrmann,G
AU - Herrman,IK
AU - Stevens,MM
DO - 10.1016/j.nantod.2015.04.004
EP - 409
PY - 2015///
SN - 1748-0132
SP - 397
TI - Cell-derived vesicles for drug therapy and diagnostics: Opportunities and challenges
T2 - Nano Today
UR - http://dx.doi.org/10.1016/j.nantod.2015.04.004
UR - http://hdl.handle.net/10044/1/23795
VL - 10
ER -