Imperial College London

Professor Molly Stevens FREng

Faculty of EngineeringDepartment of Materials

Prof of Biomedical Materials&Regenerative Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6804m.stevens

 
 
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Location

 

208Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Horejs:2017:10.1038/ncomms15509,
author = {Horejs, CM and St-Pierre, JP and Ojala, JRM and Steele, JAM and Barros, da Silva P and Rynne-Vidal, A and Maynard, SA and Hansel, CS and Rodriguez-Fernandez, C and Mazo, MM and You, AYF and Wang, AJ and von, Erlach T and Tryggvason, K and Lopez-Cabrera, M and Stevens, MM},
doi = {10.1038/ncomms15509},
journal = {Nature Communications},
title = {Preventing tissue fibrosis by local biomaterials interfacing of specific cryptic extracellular matrix information},
url = {http://dx.doi.org/10.1038/ncomms15509},
volume = {8},
year = {2017}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Matrix metalloproteinases (MMPs) contribute to the breakdown of tissue structures such as the basement membrane, promoting tissue fibrosis. Here we developed an electrospun membrane biofunctionalized with a fragment of the laminin β1-chain to modulate the expression of MMP2 in this context. We demonstrate that interfacing of the β1-fragment with the mesothelium of the peritoneal membrane via a biomaterial abrogates the release of active MMP2 in response to transforming growth factor β1 and rescues tissue integrity ex vivo and in vivo in a mouse model of peritoneal fibrosis. Importantly, our data demonstrate that the membrane inhibits MMP2 expression. Changes in the expression of epithelial-to-mesenchymal transition (EMT)-related molecules further point towards a contribution of the modulation of EMT. Biomaterial-based presentation of regulatory basement membrane signals directly addresses limitations of current therapeutic approaches by enabling a localized and specific method to counteract MMP2 release applicable to a broad range of therapeutic targets.
AU - Horejs,CM
AU - St-Pierre,JP
AU - Ojala,JRM
AU - Steele,JAM
AU - Barros,da Silva P
AU - Rynne-Vidal,A
AU - Maynard,SA
AU - Hansel,CS
AU - Rodriguez-Fernandez,C
AU - Mazo,MM
AU - You,AYF
AU - Wang,AJ
AU - von,Erlach T
AU - Tryggvason,K
AU - Lopez-Cabrera,M
AU - Stevens,MM
DO - 10.1038/ncomms15509
PY - 2017///
SN - 2041-1723
TI - Preventing tissue fibrosis by local biomaterials interfacing of specific cryptic extracellular matrix information
T2 - Nature Communications
UR - http://dx.doi.org/10.1038/ncomms15509
UR - http://hdl.handle.net/10044/1/49855
VL - 8
ER -