Imperial College London

Professor Molly Stevens FREng

Faculty of EngineeringDepartment of Materials

Prof of Biomedical Materials&Regenerative Medicine



+44 (0)20 7594 6804m.stevens




208Royal School of MinesSouth Kensington Campus






BibTex format

author = {Soh, JH and Lin, Y and Thomas, MR and Todorova, N and Kallepitis, C and Ying, JY and Yarovsky, I and Stevens, MM},
doi = {10.1002/adfm.201700523},
journal = {Advanced Functional Materials},
title = {Distinct bimodal roles of aromatic molecules in controlling gold nanorod growth for biosensing},
url = {},
volume = {27},
year = {2017}

RIS format (EndNote, RefMan)

AB - New aromatic molecule–seed particle interactions are examined and exploited to control and guide seed-mediated gold nanorod (Au NR) growth. This new approach enables better understanding of how small molecules impact the synthesis of metallic nanostructures, catalysing their use in various biomedical applications, such as plasmonic biosensing. We perform experimental studies and theoretical molecular simulations using a library of aromatic molecules where we take advantage of the chemical versatility of the molecules with varied spatial arrangements of electron donating/withdrawing groups, charge, and Au-binding propensity. Au NR growth is regulated by two principal mechanisms, producing either a red or blue shift in the longitudinal localized surface plasmon resonance (LLSPR) peaks. Aromatic molecules with high redox potentials produced an increase in NR aspect ratio and red shift of LLSPR peaks. In contrast, molecules that strongly bind gold surfaces resulted in blue shifts, demonstrating a strong correlation between their binding energy and blue shifts produced. Through enzymatic conversion of selected molecules, 4-aminophenylphosphate to 4-aminophenol, we obtained opposing growth mechanisms at opposite extremes of target concentration, and established a chemical pathway for performing plasmonic ELISA. This unlocks new strategies for tailoring substrate design and enzymatic mechanisms for controlling plasmonic response to target detection in biosensing applications.
AU - Soh,JH
AU - Lin,Y
AU - Thomas,MR
AU - Todorova,N
AU - Kallepitis,C
AU - Ying,JY
AU - Yarovsky,I
AU - Stevens,MM
DO - 10.1002/adfm.201700523
PY - 2017///
SN - 1616-3028
TI - Distinct bimodal roles of aromatic molecules in controlling gold nanorod growth for biosensing
T2 - Advanced Functional Materials
UR -
UR -
VL - 27
ER -