Imperial College London

Professor Molly Stevens FREng

Faculty of EngineeringDepartment of Materials

Prof of Biomedical Materials&Regenerative Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6804m.stevens

 
 
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Location

 

208Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Clarke:2017:10.1021/jacs.7b00528,
author = {Clarke, D and Pashuck, ET and Bertazzo, S and Weaver, JVM and Stevens, MM},
doi = {10.1021/jacs.7b00528},
journal = {Journal of the American Chemical Society},
pages = {7250--7255},
title = {Self-healing self-assembled B-sheet peptide poly(G-glutamic acid) hybrid hydrogels},
url = {http://dx.doi.org/10.1021/jacs.7b00528},
volume = {139},
year = {2017}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Self-assembled biomaterials are an important class of materials that can be injected and formed in situ. However, they often are not able to meet the mechanical properties necessary for many biological applications, losing mechanical properties at low strains. We synthesized hybrid hydrogels consisting of a poly(γ-glutamic acid) polymer network physically cross-linked via grafted self-assembling β-sheet peptides to provide non-covalent cross-linking through β-sheet assembly, reinforced with a polymer backbone to improve strain stability. By altering the β-sheet peptide graft density and concentration, we can tailor the mechanical properties of the hydrogels over an order of magnitude range of 10–200 kPa, which is in the region of many soft tissues. Also, due to the ability of the non-covalent β-sheet cross-links to reassemble, the hydrogels can self-heal after being strained to failure, in most cases recovering all of their original storage moduli. Using a combination of spectroscopic techniques, we were able to probe the secondary structure of the materials and verify the presence of β-sheets within the hybrid hydrogels. Since the polymer backbone requires less than a 15% functionalization of its repeating units with β-sheet peptides to form a hydrogel, it can easily be modified further to incorporate specific biological epitopes. This self-healing polymer−β-sheet peptide hybrid hydrogel with tailorable mechanical properties is a promising platform for future tissue-engineering scaffolds and biomedical applications.
AU - Clarke,D
AU - Pashuck,ET
AU - Bertazzo,S
AU - Weaver,JVM
AU - Stevens,MM
DO - 10.1021/jacs.7b00528
EP - 7255
PY - 2017///
SN - 1520-5126
SP - 7250
TI - Self-healing self-assembled B-sheet peptide poly(G-glutamic acid) hybrid hydrogels
T2 - Journal of the American Chemical Society
UR - http://dx.doi.org/10.1021/jacs.7b00528
UR - http://hdl.handle.net/10044/1/48543
VL - 139
ER -