Imperial College London

Professor Molly Stevens

Faculty of EngineeringDepartment of Materials

Prof of Biomedical Materials&Regenerative Medicine
 
 
 
//

Contact

 

+44 (0)20 7594 6804m.stevens

 
 
//

Location

 

208Royal School of MinesSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Littmann:2017:10.1016/j.jeurceramsoc.2017.08.001,
author = {Littmann, E and Autefage, H and Solanki, AN and Kallepitis, C and Jones, JR and Alini, M and Peroglio, M and Stevens, MM},
doi = {10.1016/j.jeurceramsoc.2017.08.001},
journal = {Journal of the European Ceramic Society},
pages = {877--886},
title = {Cobalt-containing bioactive glasses reduce humanmesenchymal stem cell chondrogenic differentiation despiteHIF-1α stabilisation},
url = {http://dx.doi.org/10.1016/j.jeurceramsoc.2017.08.001},
volume = {38},
year = {2017}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Bioactive glasses (BGs) are excellent delivery systems for the sustained release of therapeutic ions and have been extensively studied in the context of bone tissue engineering. More recently, due to their osteogenic properties and expanding application to soft tissue repair, BGs have been proposed as promising materials for use at the osteochondral interface. Since hypoxia plays a critical role during cartilage formation, we sought to investigate the influence of BGs releasing the hypoxia-mimicking agent cobalt (CoBGs) on human mesenchymal stem cell (hMSC) chondrogenesis, as a novel approach that may guide future osteochondral scaffold design. The CoBG dissolution products significantly increased the level of hypoxia-inducible factor-1 alpha in hMSCs in a cobalt dose-dependent manner. Continued exposure to the cobalt-containing BG extracts significantly reduced hMSC proliferation and metabolic activity, as well as chondrogenic differentiation. Overall, this study demonstrates that prolonged exposure to cobalt warrants careful consideration for cartilage repair applications.
AU - Littmann,E
AU - Autefage,H
AU - Solanki,AN
AU - Kallepitis,C
AU - Jones,JR
AU - Alini,M
AU - Peroglio,M
AU - Stevens,MM
DO - 10.1016/j.jeurceramsoc.2017.08.001
EP - 886
PY - 2017///
SN - 0955-2219
SP - 877
TI - Cobalt-containing bioactive glasses reduce humanmesenchymal stem cell chondrogenic differentiation despiteHIF-1α stabilisation
T2 - Journal of the European Ceramic Society
UR - http://dx.doi.org/10.1016/j.jeurceramsoc.2017.08.001
UR - http://hdl.handle.net/10044/1/50322
VL - 38
ER -