Imperial College London

Professor Molly Stevens FREng

Faculty of EngineeringDepartment of Materials

Prof of Biomedical Materials&Regenerative Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6804m.stevens

 
 
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Location

 

208Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

237 results found

Amdursky N, Wang X, Meredith P, Riley DJ, Payne DJ, Bradley D, Stevens MMet al., Electron Hopping Across Hemin-Doped Serum Albumin Mats on Centimetre-Length Scales, Advanced Materials, ISSN: 1521-4095

JOURNAL ARTICLE

Chang JYH, Chow LW, Dismuke WM, Ethier CR, Stevens MM, Stamer WD, Overby Det al., Peptide-Functionalized Fluorescent Particles for in situ Detection of Nitric Oxide via Peroxynitrite-Mediated Nitration, Advanced Healthcare Materials, ISSN: 2192-2640

JOURNAL ARTICLE

Kim E, Zwi Dantsis L, Reznikov N, Hansel CS, Agarwal S, Stevens MMet al., One-Pot Synthesis of Multiple Protein-Encapsulated DNA Flowers and Their Application in Intracellular Protein Delivery, Advanced Materials, ISSN: 1521-4095

JOURNAL ARTICLE

Soh JH, Lin Y, Thomas MR, Todorova N, Kallepitis C, Ying JY, Yarovsky I, Stevens MMet al., Distinct Bimodal Roles of Aromatic Molecules in Controlling Gold Nanorod Growth for Biosensing, Advanced Functional Materials, ISSN: 1616-3028

JOURNAL ARTICLE

Stevens MM, Horejs CM, St-Pierre JP, Ojala JRM, Steele JAM, Barros da Silva P, Rynne-Vidal A, Maynard SA, Hansel CS, Rodriguez-Fernandez C, Mazo MM, You AYF, Wang AJ, von Erlach T, Tryggvason K, Lopez-Cabrera Met al., Preventing tissue fibrosis by local biomaterials interfacing of specific cryptic extracellular matrix information, Nature Communications, ISSN: 2041-1723

JOURNAL ARTICLE

Stevens MM, Speidel AT, Stuckey DJ, Chow LW, Jackson LH, Noseda M, Abreu Pavia M, Schneider MDet al., Multi-modal hydrogel-based platform to deliver and monitor cardiac progenitor/stem cell engraftment, ACS Central Science, ISSN: 2374-7951

JOURNAL ARTICLE

Armstrong JPK, Holme MN, Stevens MM, 2017, Re-Engineering Extracellular Vesicles as Smart Nanoscale Therapeutics, ACS NANO, Vol: 11, Pages: 69-83, ISSN: 1936-0851

JOURNAL ARTICLE

Chandrawati R, Chang JY, Reina-Torres E, Jumeaux C, Sherwood JM, Stamer WD, Zelikin AN, Overby DR, Stevens MMet al., 2017, Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma., Adv Mater

Nitric oxide (NO) is able to lower intraocular pressure (IOP); however, its therapeutic effects on outflow physiology are location- and dose-dependent. An NO delivery platform that directly targets the resistance-generating region of the conventional outflow pathway and locally liberates a controlled dose of NO is reported. An increase in outflow facility (decrease in IOP) is demonstrated in a mouse model.

JOURNAL ARTICLE

Fiocco L, Li S, Stevens MM, Bernardo E, Jones JRet al., 2017, Biocompatibility and bioactivity of porous polymer-derived Ca-Mg silicate ceramics, ACTA BIOMATERIALIA, Vol: 50, Pages: 56-67, ISSN: 1742-7061

JOURNAL ARTICLE

Kallepitis C, Bergholt MS, Mazo MM, Leonardo V, Skaalure SC, Maynard SA, Stevens MMet al., 2017, Quantitative volumetric Raman imaging of three dimensional cell cultures, NATURE COMMUNICATIONS, Vol: 8, ISSN: 2041-1723

JOURNAL ARTICLE

Kim E, Howes PD, Crowder SW, Stevens MMet al., 2017, Multi-Amplified Sensing of MicroRNA by a Small DNA Fragment-Driven Enzymatic Cascade Reaction, ACS SENSORS, Vol: 2, Pages: 111-118, ISSN: 2379-3694

JOURNAL ARTICLE

Lin Y, Pashuck ET, Thomas MR, Amdursky N, Wang S-T, Chow LW, Stevens MMet al., 2017, Plasmonic Chirality Imprinting on Nucleobase-Displaying Supramolecular Nanohelices by Metal-Nucleobase Recognition, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 59, Pages: 2361-2365, ISSN: 1433-7851

JOURNAL ARTICLE

Macon ALB, Jacquemin M, Page SJ, Li S, Bertazzo S, Stevens MM, Hanna JV, Jones JRet al., 2017, Lithium-silicate sol-gel bioactive glass and the effect of lithium precursor on structure-property relationships, JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY, Vol: 81, Pages: 84-94, ISSN: 0928-0707

JOURNAL ARTICLE

Pacheco-Moreno CM, Schreck M, Scaccabarozzi AD, Bourgun P, Wantz G, Stevens MM, Dautel OJ, Stingelin Net al., 2017, The Importance of Materials Design to Make Ions Flow: Toward Novel Materials Platforms for Bioelectronics Applications, ADVANCED MATERIALS, Vol: 29, ISSN: 0935-9648

JOURNAL ARTICLE

Parmar PA, St-Pierre JP, Chow LW, Spicer CD, Stoichevska V, Peng YY, Werkmeister JA, Ramshaw JA, Stevens MMet al., 2017, Enhanced articular cartilage by human mesenchymal stem cells in enzymatically mediated transiently RGDS-functionalized collagen-mimetic hydrogels., Acta Biomater, Vol: 51, Pages: 75-88

Recapitulation of the articular cartilage microenvironment for regenerative medicine applications faces significant challenges due to the complex and dynamic biochemical and biomechanical nature of native tissue. Towards the goal of biomaterial designs that enable the temporal presentation of bioactive sequences, recombinant bacterial collagens such as Streptococcal collagen-like 2 (Scl2) proteins can be employed to incorporate multiple specific bioactive and biodegradable peptide motifs into a single construct. Here, we first modified the backbone of Scl2 with glycosaminoglycan-binding peptides and cross-linked the modified Scl2 into hydrogels via matrix metalloproteinase 7 (MMP7)-cleavable or non-cleavable scrambled peptides. The cross-linkers were further functionalized with a tethered RGDS peptide creating a system whereby the release from an MMP7-cleavable hydrogel could be compared to a system where release is not possible. The release of the RGDS peptide from the degradable hydrogels led to significantly enhanced expression of collagen type II (3.9-fold increase), aggrecan (7.6-fold increase), and SOX9 (5.2-fold increase) by human mesenchymal stem cells (hMSCs) undergoing chondrogenesis, as well as greater extracellular matrix accumulation compared to non-degradable hydrogels (collagen type II; 3.2-fold increase, aggrecan; 4-fold increase, SOX9; 2.8-fold increase). Hydrogels containing a low concentration of the RGDS peptide displayed significantly decreased collagen type I and X gene expression profiles, suggesting a major advantage over either hydrogels functionalized with a higher RGDS peptide concentration, or non-degradable hydrogels, in promoting an articular cartilage phenotype. These highly versatile Scl2 hydrogels can be further manipulated to improve specific elements of the chondrogenic response by hMSCs, through the introduction of additional bioactive and/or biodegradable motifs. As such, these hydrogels have the possibility to be used for other

JOURNAL ARTICLE

Pelaz B, Alexiou C, Alvarez -Puebla RA, Alves F, Andrews AM, Ashraf S, Balogh LP, Ballerini L, Bestetti A, Brendel C, Bosi S, Carril M, Chan WCW, Chen C, Chen X, Chen X, Cheng Z, Cui D, Du J, Dullin C, Escudero A, Feliu N, Gao M, George M, Gogotsi Y, Grunweller A, Gu Z, Halas NJ, Hampp N, Hartmann RK, Hersam MC, Hunziker P, Jian J, Jiang X, Jungebluth P, Kadhiresan P, Kataoka K, Khademhosseini A, Kopecek J, Kotov NA, Krug HF, Lee DS, Lehr C-M, Leong KW, Liang X-J, Lim ML, Liz-Marzan LM, Ma X, Macchiarini P, Meng H, Mohwald H, Mulvaney P, Nel AE, Nie S, Nordlander P, Okano T, Oliveira J, Park TH, Penner RM, Prato M, Puntes V, Rotello VM, Samarakoon A, Schaak RE, Shen Y, Sjoqvist S, Skirtach AG, Soliman MG, Stevens MM, Sung H-W, Tang BZ, Tietze R, Udugama BN, VanEpps JS, Weil T, Weiss PS, Willner I, Wu Y, Yang L, Yue Z, Zhang Q, Zhang Q, Zhang X-E, Zhao Y, Zhou X, Parak WJet al., 2017, Diverse Applications of Nanomedicine, ACS NANO, Vol: 11, Pages: 2313-2381, ISSN: 1936-0851

JOURNAL ARTICLE

Spicer CD, Booth MA, Mawad D, Armgarth A, Nielsen CB, Stevens MMet al., 2017, Synthesis of Hetero-bifunctional, End-Capped Oligo-EDOT Derivatives., Chem, Vol: 2, Pages: 125-138

Conjugated oligomers of 3,4-ethylenedioxythiophene (EDOT) are attractive materials for tissue engineering applications and as model systems for studying the properties of the widely used polymer poly(3,4-ethylenedioxythiophene). We report here the facile synthesis of a series of keto-acid end-capped oligo-EDOT derivatives (n = 2-7) through a combination of a glyoxylation end-capping strategy and iterative direct arylation chain extension. Importantly, these structures not only represent the longest oligo-EDOTs reported but are also bench stable, in contrast to previous reports on such oligomers. The constructs reported here can undergo subsequent derivatization for integration into higher-order architectures, such as those required for tissue engineering applications. The synthesis of hetero-bifunctional constructs, as well as those containing mixed-monomer units, is also reported, allowing further complexity to be installed in a controlled manner. Finally, we describe the optical and electrochemical properties of these oligomers and demonstrate the importance of the keto-acid in determining their characteristics.

JOURNAL ARTICLE

Wang S-T, Lin Y, Todorova N, Xu Y, Mazo M, Rana S, Leonardo V, Amdursky N, Spicer CD, Alexander BD, Edwards AA, Matthews SJ, Yarovsky I, Stevens MMet al., 2017, Facet-Dependent Interactions of Islet Amyloid Polypeptide with Gold Nanoparticles: Implications for Fibril Formation and Peptide-Induced Lipid Membrane Disruption, CHEMISTRY OF MATERIALS, Vol: 29, Pages: 1550-1560, ISSN: 0897-4756

JOURNAL ARTICLE

Amdursky N, Wang X, Meredith P, Bradley DDC, Stevens MMet al., 2016, Long-Range Proton Conduction across Free-Standing Serum Albumin Mats, ADVANCED MATERIALS, Vol: 28, Pages: 2692-2698, ISSN: 0935-9648

JOURNAL ARTICLE

Bell RV, Parkins CC, Young RA, Preuss CM, Stevens MM, Bon SAFet al., 2016, Assembly of emulsion droplets into fibers by microfluidic wet spinning, JOURNAL OF MATERIALS CHEMISTRY A, Vol: 4, Pages: 813-818, ISSN: 2050-7488

JOURNAL ARTICLE

Bergholt MS, St-Pierre J-P, Offeddu GS, Parmar PA, Albro MB, Puetzer JL, Oyen ML, Stevens MMet al., 2016, Raman Spectroscopy Reveals New Insights into the Zonal Organization of Native and Tissue-Engineered Articular Cartilage, ACS CENTRAL SCIENCE, Vol: 2, Pages: 885-895, ISSN: 2374-7943

JOURNAL ARTICLE

Blaeser A, Campos DFD, Puster U, Richtering W, Stevens MM, Fischer Het al., 2016, Controlling Shear Stress in 3D Bioprinting is a Key Factor to Balance Printing Resolution and Stem Cell Integrity, ADVANCED HEALTHCARE MATERIALS, Vol: 5, Pages: 326-333, ISSN: 2192-2640

JOURNAL ARTICLE

Campagnolo P, Gormley AJ, Chow LW, Guex AG, Parmar PA, Puetzer JL, Steele JAM, Breant A, Madeddu P, Stevens MMet al., 2016, Pericyte Seeded Dual Peptide Scaffold with Improved Endothelialization for Vascular Graft Tissue Engineering, ADVANCED HEALTHCARE MATERIALS, Vol: 5, Pages: 3046-3055, ISSN: 2192-2640

JOURNAL ARTICLE

Chapman R, Gormley AJ, Stenzel MH, Stevens MMet al., 2016, Combinatorial Low-Volume Synthesis of Well-Defined Polymers by Enzyme Degassing, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Vol: 55, Pages: 4500-4503, ISSN: 1433-7851

JOURNAL ARTICLE

Chung JJ, Li S, Stevens MM, Georgiou TK, Jones JRet al., 2016, Tailoring Mechanical Properties of Sol-Gel Hybrids for Bone Regeneration through Polymer Structure, CHEMISTRY OF MATERIALS, Vol: 28, Pages: 6127-6135, ISSN: 0897-4756

JOURNAL ARTICLE

Crowder SW, Leonardo V, Whittaker T, Papathanasiou P, Stevens MMet al., 2016, Material Cues as Potent Regulators of Epigenetics and Stem Cell Function, CELL STEM CELL, Vol: 18, Pages: 39-52, ISSN: 1934-5909

JOURNAL ARTICLE

Fiocco L, Li S, Bernardo E, Stevens MM, Jones JRet al., 2016, Highly porous polymer-derived wollastonite-hydroxycarbonate apatite ceramics for bone regeneration, BIOMEDICAL MATERIALS, Vol: 11, ISSN: 1748-6041

JOURNAL ARTICLE

Flamant Q, Caravaca C, Meille S, Gremillard L, Chevalier J, Biotteau-Deheuvels K, Kuntz M, Chandrawati R, Herrmann IK, Spicer CD, Stevens MM, Anglada Met al., 2016, Selective etching of injection molded zirconia-toughened alumina: Towards osseointegrated and antibacterial ceramic implants, ACTA BIOMATERIALIA, Vol: 46, Pages: 308-322, ISSN: 1742-7061

JOURNAL ARTICLE

Gliddon HD, Howes PD, Kaforou M, Levin M, Stevens MMet al., 2016, A nucleic acid strand displacement system for the multiplexed detection of tuberculosis-specific mRNA using quantum dots, NANOSCALE, Vol: 8, Pages: 10087-10095, ISSN: 2040-3364

JOURNAL ARTICLE

He M, Callanan A, Lagaras K, Steele JA, Stevens MMet al., 2016, Optimization of SDS exposure on preservation of ECM characteristics in whole organ decellularization of rat kidneys., J Biomed Mater Res B Appl Biomater

Renal transplantation is well established as the optimal form of renal replacement therapy but is restricted by the limited pool of organs available for transplantation. The whole organ decellularisation approach is leading the way for a regenerative medicine solution towards bioengineered organ replacements. However, systematic preoptimization of both decellularization and recellularization parameters is essential prior to any potential clinical application and should be the next stage in the evolution of whole organ decellularization as a potential strategy for bioengineered organ replacements. Here we have systematically assessed two fundamental parameters (concentration and duration of perfusion) with regards to the effects of differing exposure to the most commonly used single decellularizing agent (sodium dodecyl sulphate/SDS) in the perfusion decellularization process for whole rat kidney ECM bioscaffolds, with findings showing improved preservation of both structural and functional components of the whole kidney ECM bioscaffold. Whole kidney bioscaffolds based on our enhanced protocol were successfully recellularized with rat primary renal cells and mesenchymal stromal cells. These findings should be widely applicable to decellularized whole organ bioscaffolds and their optimization in the development of regenerated organ replacements for transplantation. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2016.

JOURNAL ARTICLE

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