Imperial College London

Professor Molly Stevens FREng

Faculty of EngineeringDepartment of Materials

Prof of Biomedical Materials&Regenerative Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6804m.stevens

 
 
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Location

 

208Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

328 results found

Reznikov N, Boughton O, Ghouse S, Weston AE, Collinson L, Blunn GW, Jeffers J, Cobb J, Stevens Met al., 2018, Individual response variations in scaffold-guided bone regeneration are determined by independent strain- and injury-induced mechanisms, Biomaterials, ISSN: 0142-9612

JOURNAL ARTICLE

Armstrong JPK, Puetzer JL, Serio A, Guex AG, Kapnisi M, Breant A, Zong Y, Assal V, Skaalure SC, King O, Murty T, Meinert C, Franklin AC, Bassindale PG, Nichols MK, Terracciano CM, Hutmacher DW, Drinkwater BW, Klein TJ, Perriman AW, Stevens MMet al., 2018, Engineering Anisotropic Muscle Tissue using Acoustic Cell Patterning, ADVANCED MATERIALS, Vol: 30, ISSN: 0935-9648

JOURNAL ARTICLE

Penders J, Pence IJ, Horgan CC, Bergholt MS, Wood CS, Najer A, Kauscher U, Nagelkerke A, Stevens MMet al., 2018, Single Particle Automated Raman Trapping Analysis, NATURE COMMUNICATIONS, Vol: 9, ISSN: 2041-1723

JOURNAL ARTICLE

Gray ER, Bain R, Varsaneux O, Peeling RW, Stevens MM, McKendry RAet al., 2018, p24 revisited: a landscape review of antigen detection for early HIV diagnosis., AIDS, Vol: 32, Pages: 2089-2102

: Despite major advances in HIV testing, early detection of infection at the point of care (PoC) remains a key challenge. Although rapid antibody PoC and laboratory-based nucleic acid amplification tests dominate the diagnostics market, the viral capsid protein p24 is recognized as an alternative early virological biomarker of infection. However, the detection of ultra-low levels of p24 at the PoC has proven challenging. Here we review the landscape of p24 diagnostics to identify knowledge gaps and barriers and help shape future research agendas. Five hundred and seventy-four research articles to May 2018 that propose or evaluate diagnostic assays for p24 were identified and reviewed. We give a brief history of diagnostic development, and the utility of p24 as a biomarker in different populations such as infants, the newly infected, those on preexposure prophylaxis and self-testers. We review the performance of commercial p24 assays and consider elements such as immune complex disruption, resource-poor settings, prevalence, and assay antibodies. Emerging and ultrasensitive assays are reviewed and show a number of promising approaches but further translation has been limited. We summarize studies on the health economic benefits of using antigen testing. Finally, we speculate on the future uses of high-performance p24 assays, particularly, if available in self-test format.

JOURNAL ARTICLE

Amdursky N, Mazo MM, Thomas MR, Humphrey EJ, Puetzer JL, St-Pierre J-P, Skaalure SC, Richardson RM, Terracciano CM, Stevens MMet al., 2018, Elastic serum-albumin based hydrogels: mechanism of formation and application in cardiac tissue engineering, JOURNAL OF MATERIALS CHEMISTRY B, Vol: 6, Pages: 5604-5612, ISSN: 2050-750X

JOURNAL ARTICLE

Faria M, Bjornmalm M, Thurecht KJ, Kent SJ, Parton RG, Kavallaris M, Johnston APR, Gooding JJ, Corrie SR, Boyd BJ, Thordarson P, Whittaker AK, Stevens MM, Prestidge CA, Porter CJH, Parak WJ, Davis TP, Crampin EJ, Caruso Fet al., 2018, Minimum information reporting in bio-nano experimental literature, NATURE NANOTECHNOLOGY, Vol: 13, Pages: 777-785, ISSN: 1748-3387

JOURNAL ARTICLE

Sigmundsson K, Ojala JRM, Ohman MK, Osterholm A-M, Moreno-Moral A, Domogatskaya A, Chong LY, Sun Y, Chai X, Steele JAM, George B, Patarroyo M, Nilsson A-S, Rodin S, Ghosh S, Stevens MM, Petretto E, Tryggvason Ket al., 2018, Culturing functional pancreatic islets on alpha 5-Iaminins and curative transplantation , to diabetic mice, MATRIX BIOLOGY, Vol: 70, Pages: 5-19, ISSN: 0945-053X

JOURNAL ARTICLE

Tallia F, Russo L, Li S, Orrin ALH, Shi X, Chen S, Steele JAM, Meille S, Chevalier J, Lee PD, Stevens MM, Cipolla L, Jones JRet al., 2018, Bouncing and 3D printable hybrids with self-healing properties, MATERIALS HORIZONS, Vol: 5, Pages: 849-860, ISSN: 2051-6347

JOURNAL ARTICLE

Li C, Armstrong JPK, Pence IJ, Kit-Anan W, Puetzer JL, Carreira SC, Moore AC, Stevens MMet al., 2018, Glycosylated superparamagnetic nanoparticle gradients for osteochondral tissue engineering, BIOMATERIALS, Vol: 176, Pages: 24-33, ISSN: 0142-9612

JOURNAL ARTICLE

Wang Y, Howes PD, Kim E, Spicer CD, Thomas MR, Lin Y, Crowder SW, Pence IJ, Stevens MMet al., 2018, Duplex-Specific Nuclease-Amplified Detection of MicroRNA Using Compact Quantum Dot-DNA Conjugates, ACS APPLIED MATERIALS & INTERFACES, Vol: 10, Pages: 28290-28300, ISSN: 1944-8244

JOURNAL ARTICLE

Spicer CD, Pashuck ET, Stevens MM, 2018, Achieving Controlled Biomolecule-Biomaterial Conjugation, CHEMICAL REVIEWS, Vol: 118, Pages: 7702-7743, ISSN: 0009-2665

JOURNAL ARTICLE

Holme MN, Rashid MH, Thomas MR, Barriga HMG, Herpoldt K-L, Heenan RK, Dreiss CA, Banuelos JL, Xie H-N, Yarovsky I, Stevens MMet al., 2018, Fate of Liposomes in the Presence of Phospholipase C and D: From Atomic to Supramolecular Lipid Arrangement, ACS CENTRAL SCIENCE, Vol: 4, Pages: 1023-1030, ISSN: 2374-7943

JOURNAL ARTICLE

Creamer A, Wood CS, Howes PD, Casey A, Cong S, Marsh AV, Godin R, Panidi J, Anthopoulos TD, Burgess CH, Wu T, Fei Z, Hamilton I, McLachlan MA, Stevens MM, Heeney Met al., 2018, Post-polymerisation functionalisation of conjugated polymer backbones and its application in multifunctional emissive nanoparticles, NATURE COMMUNICATIONS, Vol: 9, ISSN: 2041-1723

JOURNAL ARTICLE

Holme MN, Rana S, Barriga HMG, Kauscher U, Brooks NJ, Stevens MMet al., 2018, A Robust Liposomal Platform for Direct Colorimetric Detection of Sphingomyelinase Enzyme and Inhibitors, ACS NANO, Vol: 12, Pages: 8197-8207, ISSN: 1936-0851

JOURNAL ARTICLE

Barriga HMG, Holme MN, Stevens MM, 2018, Cubosomes: The Next Generation of Smart Lipid Nanoparticles?, Angew Chem Int Ed Engl

Cubosomes are highly stable nanoparticles formed from the lipid cubic phase and stabilized by a polymer based outer corona. Bicontinuous lipid cubic phases consist of a single lipid bilayer that forms a continuous periodic membrane lattice structure with pores formed by two interwoven water channels. Cubosome composition can be tuned to engineer pore sizes or include bioactive lipids, the polymer outer corona can be used for targeting and they are highly stable under physiological conditions. Compared to liposomes, the structure provides a significantly higher membrane surface area for loading of membrane proteins and small drug molecules. Owing to recent advances, they can be engineered in vitro in both bulk and nanoparticle formats with applications including drug delivery, membrane bioreactors, artificial cells, and biosensors. This review outlines recent advances in cubosome technology enabling their application and provides guidelines for the rational design of new systems for biomedical applications.

JOURNAL ARTICLE

Sang T, Li S, Ting H-K, Stevens MM, Becer CR, Jones JRet al., 2018, Hybrids of Silica/Poly(caprolactone coglycidoxypropyl trimethoxysilane) as Biomaterials, CHEMISTRY OF MATERIALS, Vol: 30, Pages: 3743-3751, ISSN: 0897-4756

JOURNAL ARTICLE

Elsharkawy S, Al-Jawad M, Pantano MF, Tejeda-Montes E, Mehta K, Jamal H, Agarwal S, Shuturminska K, Rice A, Tarakina N, Wilson RM, Bushby AJ, Alonso M, Rodriguez-Cabello JC, Barbieft E, Hernandez ADR, Stevens MM, Pugno NM, Anderson P, Mata Aet al., 2018, Protein disorder-order interplay to guide the growth of hierarchical mineralized structures, NATURE COMMUNICATIONS, Vol: 9, ISSN: 2041-1723

JOURNAL ARTICLE

Kapnisi M, Mansfield C, Marijon C, Guex AG, Perbellini F, Bardi I, Humphrey EJ, Puetzer JL, Mawad D, Koutsogeorgis DC, Stuckey DJ, Terracciano CM, Harding SE, Stevens MMet al., 2018, Auxetic Cardiac Patches with Tunable Mechanical and Conductive Properties toward Treating Myocardial Infarction, ADVANCED FUNCTIONAL MATERIALS, Vol: 28, ISSN: 1616-301X

JOURNAL ARTICLE

Spicer CD, Jumeaux C, Gupta B, Stevens MMet al., 2018, Peptide and protein nanoparticle conjugates: versatile platforms for biomedical applications, CHEMICAL SOCIETY REVIEWS, Vol: 47, Pages: 3574-3620, ISSN: 0306-0012

JOURNAL ARTICLE

Reznikov N, Bilton M, Lari L, Stevens MM, Kroger Ret al., 2018, Fractal-like hierarchical organization of bone begins at the nanoscale, SCIENCE, Vol: 360, Pages: 507-+, ISSN: 0036-8075

JOURNAL ARTICLE

Armstrong JPK, Stevens MM, 2018, Strategic design of extracellular vesicle drug delivery systems, ADVANCED DRUG DELIVERY REVIEWS, Vol: 130, Pages: 12-16, ISSN: 0169-409X

JOURNAL ARTICLE

Fuhrmann G, Chandrawati R, Parmar PA, Keane TJ, Maynard SA, Bertazzo S, Stevens MMet al., 2018, Engineering Extracellular Vesicles with the Tools of Enzyme Prodrug Therapy, ADVANCED MATERIALS, Vol: 30, ISSN: 0935-9648

JOURNAL ARTICLE

Winther AK, Fejerskov B, ter Meer M, Jensen NBS, Dillison R, Schaffer JE, Chandrawati R, Stevens MM, Kool LJS, Simonsen U, Zelikin ANet al., 2018, Enzyme Prodrug Therapy Achieves Site-Specific, Personalized Physiological Responses to the Locally Produced Nitric Oxide, ACS APPLIED MATERIALS & INTERFACES, Vol: 10, Pages: 10741-10751, ISSN: 1944-8244

JOURNAL ARTICLE

Keane TJ, Horejs C-M, Stevens MM, 2018, Scarring vs. functional healing: Matrix-based strategies to regulate tissue repair, ADVANCED DRUG DELIVERY REVIEWS, Vol: 129, Pages: 407-419, ISSN: 0169-409X

JOURNAL ARTICLE

Jumeaux C, Wahlsten O, Block S, Kim E, Chandrawati R, Howes PD, Hook F, Stevens MMet al., 2018, MicroRNA Detection by DNA-Mediated Liposome Fusion, CHEMBIOCHEM, Vol: 19, Pages: 434-438, ISSN: 1439-4227

JOURNAL ARTICLE

von Erlach TC, Bertazzo S, Wozniak MA, Horejs C-M, Maynard SA, Attwood S, Robinson BK, Autefage H, Kallepitis C, Hernandez ADR, Chen CS, Goldoni S, Stevens MMet al., 2018, Cell-geometry-dependent changes in plasma membrane order direct stem cell signalling and fate, NATURE MATERIALS, Vol: 17, Pages: 237-+, ISSN: 1476-1122

JOURNAL ARTICLE

Littmann E, Autefage H, Solanki AK, Kallepitis C, Jones JR, Alini M, Peroglio M, Stevens MMet al., 2018, Cobalt-containing bioactive glasses reduce human mesenchymal stem cell chondrogenic differentiation despite HIF-1 alpha stabilisation, JOURNAL OF THE EUROPEAN CERAMIC SOCIETY, Vol: 38, Pages: 877-886, ISSN: 0955-2219

JOURNAL ARTICLE

Hsu C-C, Serio A, Arndursky N, Besnard C, Stevens MMet al., 2018, Fabrication of Hemin-Doped Serum Albumin-Based Fibrous Scaffolds for Neural Tissue Engineering Applications, ACS APPLIED MATERIALS & INTERFACES, Vol: 10, Pages: 5305-5317, ISSN: 1944-8244

JOURNAL ARTICLE

Albro MB, Bergholt MS, St-Pierre JP, Guitart AV, Zlotnick HM, Evita EG, Stevens MMet al., 2018, Raman spectroscopic imaging for quantification of depth-dependent and local heterogeneities in native and engineered cartilage, NPJ REGENERATIVE MEDICINE, Vol: 3, ISSN: 2057-3995

JOURNAL ARTICLE

Bergholt MS, Serio A, McKenzie JS, Boyd A, Soares RF, Tillner J, Chiappini C, Wu V, Dannhorn A, Takats Z, Williams A, Stevens MMet al., 2018, Correlated Heterospectral Lipidomics for Biomolecular Profiling of Remyelination in Multiple Sclerosis, ACS CENTRAL SCIENCE, Vol: 4, Pages: 39-51, ISSN: 2374-7943

JOURNAL ARTICLE

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