321 results found
Albro MB, Bergholt MS, St-Pierre JP, et al., 2018, Raman spectroscopic imaging for quantification of depth-dependent and local heterogeneities in native and engineered cartilage, NPJ REGENERATIVE MEDICINE, Vol: 3, ISSN: 2057-3995
Amdursky N, Mazo MM, Thomas MR, et al., 2018, Elastic serum-albumin based hydrogels: mechanism of formation and application in cardiac tissue engineering, JOURNAL OF MATERIALS CHEMISTRY B, Vol: 6, Pages: 5604-5612, ISSN: 2050-750X
Armstrong JPK, Puetzer JL, Serio A, et al., 2018, Engineering Anisotropic Muscle Tissue using Acoustic Cell Patterning., Adv Mater
Tissue engineering has offered unique opportunities for disease modeling and regenerative medicine; however, the success of these strategies is dependent on faithful reproduction of native cellular organization. Here, it is reported that ultrasound standing waves can be used to organize myoblast populations in material systems for the engineering of aligned muscle tissue constructs. Patterned muscle engineered using type I collagen hydrogels exhibits significant anisotropy in tensile strength, and under mechanical constraint, produced microscale alignment on a cell and fiber level. Moreover, acoustic patterning of myoblasts in gelatin methacryloyl hydrogels significantly enhances myofibrillogenesis and promotes the formation of muscle fibers containing aligned bundles of myotubes, with a width of 120-150 µm and a spacing of 180-220 µm. The ability to remotely pattern fibers of aligned myotubes without any material cues or complex fabrication procedures represents a significant advance in the field of muscle tissue engineering. In general, these results are the first instance of engineered cell fibers formed from the differentiation of acoustically patterned cells. It is anticipated that this versatile methodology can be applied to many complex tissue morphologies, with broader relevance for spatially organized cell cultures, organoid development, and bioelectronics.
Armstrong JPK, Stevens MM, 2018, Strategic design of extracellular vesicle drug delivery systems, ADVANCED DRUG DELIVERY REVIEWS, Vol: 130, Pages: 12-16, ISSN: 0169-409X
Barriga HMG, Holme MN, Stevens MM, 2018, Cubosomes: The Next Generation of Smart Lipid Nanoparticles?, Angew Chem Int Ed Engl
Cubosomes are highly stable nanoparticles formed from the lipid cubic phase and stabilized by a polymer based outer corona. Bicontinuous lipid cubic phases consist of a single lipid bilayer that forms a continuous periodic membrane lattice structure with pores formed by two interwoven water channels. Cubosome composition can be tuned to engineer pore sizes or include bioactive lipids, the polymer outer corona can be used for targeting and they are highly stable under physiological conditions. Compared to liposomes, the structure provides a significantly higher membrane surface area for loading of membrane proteins and small drug molecules. Owing to recent advances, they can be engineered in vitro in both bulk and nanoparticle formats with applications including drug delivery, membrane bioreactors, artificial cells, and biosensors. This review outlines recent advances in cubosome technology enabling their application and provides guidelines for the rational design of new systems for biomedical applications.
Bergholt MS, Serio A, McKenzie JS, et al., 2018, Correlated Heterospectral Lipidomics for Biomolecular Profiling of Remyelination in Multiple Sclerosis, ACS CENTRAL SCIENCE, Vol: 4, Pages: 39-51, ISSN: 2374-7943
Brangel P, Sobarzo A, Parolo C, et al., 2018, A Serological Point-of-Care Test for the Detection of IgG Antibodies against Ebola Virus in Human Survivors, ACS NANO, Vol: 12, Pages: 63-73, ISSN: 1936-0851
Creamer A, Wood CS, Howes PD, et al., 2018, Post-polymerisation functionalisation of conjugated polymer backbones and its application in multifunctional emissive nanoparticles, NATURE COMMUNICATIONS, Vol: 9, ISSN: 2041-1723
Elsharkawy S, Al-Jawad M, Pantano MF, et al., 2018, Protein disorder-order interplay to guide the growth of hierarchical mineralized structures, NATURE COMMUNICATIONS, Vol: 9, ISSN: 2041-1723
Faria M, Bjornmalm M, Thurecht KJ, et al., 2018, Minimum information reporting in bio-nano experimental literature, NATURE NANOTECHNOLOGY, Vol: 13, Pages: 777-785, ISSN: 1748-3387
Fuhrmann G, Chandrawati R, Parmar PA, et al., 2018, Engineering Extracellular Vesicles with the Tools of Enzyme Prodrug Therapy, ADVANCED MATERIALS, Vol: 30, ISSN: 0935-9648
Gray ER, Bain R, Varsaneux O, et al., 2018, p24 revisited: a landscape review of antigen detection for early HIV diagnosis., AIDS, Vol: 32, Pages: 2089-2102
: Despite major advances in HIV testing, early detection of infection at the point of care (PoC) remains a key challenge. Although rapid antibody PoC and laboratory-based nucleic acid amplification tests dominate the diagnostics market, the viral capsid protein p24 is recognized as an alternative early virological biomarker of infection. However, the detection of ultra-low levels of p24 at the PoC has proven challenging. Here we review the landscape of p24 diagnostics to identify knowledge gaps and barriers and help shape future research agendas. Five hundred and seventy-four research articles to May 2018 that propose or evaluate diagnostic assays for p24 were identified and reviewed. We give a brief history of diagnostic development, and the utility of p24 as a biomarker in different populations such as infants, the newly infected, those on preexposure prophylaxis and self-testers. We review the performance of commercial p24 assays and consider elements such as immune complex disruption, resource-poor settings, prevalence, and assay antibodies. Emerging and ultrasensitive assays are reviewed and show a number of promising approaches but further translation has been limited. We summarize studies on the health economic benefits of using antigen testing. Finally, we speculate on the future uses of high-performance p24 assays, particularly, if available in self-test format.
Holme MN, Rana S, Barriga HMG, et al., 2018, A Robust Liposomal Platform for Direct Colorimetric Detection of Sphingomyelinase Enzyme and Inhibitors, ACS NANO, Vol: 12, Pages: 8197-8207, ISSN: 1936-0851
Holme MN, Rashid MH, Thomas MR, et al., 2018, Fate of Liposomes in the Presence of Phospholipase C and D: From Atomic to Supramolecular Lipid Arrangement, ACS CENTRAL SCIENCE, Vol: 4, Pages: 1023-1030, ISSN: 2374-7943
Hsu C-C, Serio A, Arndursky N, et al., 2018, Fabrication of Hemin-Doped Serum Albumin-Based Fibrous Scaffolds for Neural Tissue Engineering Applications, ACS APPLIED MATERIALS & INTERFACES, Vol: 10, Pages: 5305-5317, ISSN: 1944-8244
Jumeaux C, Wahlsten O, Block S, et al., 2018, MicroRNA Detection by DNA-Mediated Liposome Fusion, CHEMBIOCHEM, Vol: 19, Pages: 434-438, ISSN: 1439-4227
Kapnisi M, Mansfield C, Marijon C, et al., 2018, Auxetic Cardiac Patches with Tunable Mechanical and Conductive Properties toward Treating Myocardial Infarction, ADVANCED FUNCTIONAL MATERIALS, Vol: 28, ISSN: 1616-301X
Keane TJ, Horejs C-M, Stevens MM, 2018, Scarring vs. functional healing: Matrix-based strategies to regulate tissue repair, ADVANCED DRUG DELIVERY REVIEWS, Vol: 129, Pages: 407-419, ISSN: 0169-409X
Li C, Armstrong JPK, Pence IJ, et al., 2018, Glycosylated superparamagnetic nanoparticle gradients for osteochondral tissue engineering, BIOMATERIALS, Vol: 176, Pages: 24-33, ISSN: 0142-9612
Littmann E, Autefage H, Solanki AK, et al., 2018, Cobalt-containing bioactive glasses reduce human mesenchymal stem cell chondrogenic differentiation despite HIF-1 alpha stabilisation, JOURNAL OF THE EUROPEAN CERAMIC SOCIETY, Vol: 38, Pages: 877-886, ISSN: 0955-2219
Loynachan CN, Thomas MR, Gray ER, et al., 2018, Platinum Nanocatalyst Amplification: Redefining the Gold Standard for Lateral Flow Immunoassays with Ultrabroad Dynamic Range, ACS NANO, Vol: 12, Pages: 279-288, ISSN: 1936-0851
Milner PE, Parkes M, Puetzer JL, et al., 2018, A low friction, biphasic and boundary lubricating hydrogel for cartilage replacement, ACTA BIOMATERIALIA, Vol: 65, Pages: 102-111, ISSN: 1742-7061
Reznikov N, Bilton M, Lari L, et al., 2018, Fractal-like hierarchical organization of bone begins at the nanoscale, SCIENCE, Vol: 360, Pages: 507-+, ISSN: 0036-8075
Rizzo R, Alvaro M, Danz N, et al., 2018, Bloch surface wave enhanced biosensor for the direct detection of angiopoietin-2 tumor biomarker in human plasma, Biomedical Optics Express, Vol: 9, Pages: 529-542, ISSN: 2156-7085
Quantitative detection of angiogenic biomarkers provides a powerful tool to diagnose cancers in early stages and to follow its progression during therapy. Conventional tests require trained personnel, dedicated laboratory equipment and are generally time-consuming. Herein, we propose our developed biosensing platform as a useful tool for a rapid determination of Angiopoietin-2 biomarker directly from patient plasma within 30 minutes, without any sample preparation or dilution. Bloch surface waves supported by one dimensional photonic crystal are exploited to enhance and redirect the fluorescence arising from a sandwich immunoassay that involves Angiopoietin-2. The sensing units consist of disposable and low-cost plastic biochips coated with the photonic crystal. The biosensing platform is demonstrated to detect Angiopoietin-2 in plasma samples at the clinically relevant concentration of 6 ng/mL, with an estimated limit of detection of approximately 1 ng/mL. This is the first Bloch surface wave based assay capable of detecting relevant concentrations of an angiogenic factor in plasma samples. The results obtained by the developed biosensing platform are in close agreement with enzyme-linked immunosorbent assays, demonstrating a good accuracy, and their repeatability showed acceptable relative variations.
Sang T, Li S, Ting H-K, et al., 2018, Hybrids of Silica/Poly(caprolactone coglycidoxypropyl trimethoxysilane) as Biomaterials, CHEMISTRY OF MATERIALS, Vol: 30, Pages: 3743-3751, ISSN: 0897-4756
Sigmundsson K, Ojala JRM, Ohman MK, et al., 2018, Culturing functional pancreatic islets on alpha 5-Iaminins and curative transplantation , to diabetic mice, MATRIX BIOLOGY, Vol: 70, Pages: 5-19, ISSN: 0945-053X
Spicer CD, Jumeaux C, Gupta B, et al., 2018, Peptide and protein nanoparticle conjugates: versatile platforms for biomedical applications, CHEMICAL SOCIETY REVIEWS, Vol: 47, Pages: 3574-3620, ISSN: 0306-0012
Spicer CD, Pashuck ET, Stevens MM, 2018, Achieving Controlled Biomolecule-Biomaterial Conjugation, CHEMICAL REVIEWS, Vol: 118, Pages: 7702-7743, ISSN: 0009-2665
Wang Y, Howes PD, Kim E, et al., 2018, Duplex-Specific Nuclease-Amplified Detection of MicroRNA Using Compact Quantum Dot-DNA Conjugates, ACS APPLIED MATERIALS & INTERFACES, Vol: 10, Pages: 28290-28300, ISSN: 1944-8244
Winther AK, Fejerskov B, ter Meer M, et al., 2018, Enzyme Prodrug Therapy Achieves Site-Specific, Personalized Physiological Responses to the Locally Produced Nitric Oxide, ACS APPLIED MATERIALS & INTERFACES, Vol: 10, Pages: 10741-10751, ISSN: 1944-8244
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