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BibTex format

@article{Barriga:2019:10.1002/anie.201804067,
author = {Barriga, HMG and Holme, MN and Stevens, MM},
doi = {10.1002/anie.201804067},
journal = {Angewandte Chemie},
pages = {2958--2978},
title = {Cubosomes: the next generation of smart lipid nanoparticles?},
url = {http://dx.doi.org/10.1002/anie.201804067},
volume = {58},
year = {2019}
}

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TY  - JOUR
AB  - Cubosomes are highly stable nanoparticles formed from the lipid cubic phase and stabilized by a polymer based outer corona. Lipid cubic phases consist of a single lipid bilayer which forms a continuous periodic membrane lattice structure with pores formed by two interwoven water channels. Cubosome composition can be tuned to engineer pore sizes or include bioactive lipids, the polymer outer corona can be used for targeting and they are highly stable under physiological conditions. The structure provides a significantly higher membrane surface area for loading of membrane proteins and small drug molecules than liposomes. Due to recent advances, they can be engineered in vitro in both bulk and nanoparticle formats with applications including drug delivery, membrane bioreactors, artificial cells and biosensors. This review outlines recent advances in cubosome technology enabling their application and provides guidelines for the rational design of new systems for biomedical applications.
AU  - Barriga,HMG
AU  - Holme,MN
AU  - Stevens,MM
DO  - 10.1002/anie.201804067
EP  - 2978
PY  - 2019///
SN  - 1521-3757
SP  - 2958
TI  - Cubosomes: the next generation of smart lipid nanoparticles?
T2  - Angewandte Chemie
UR  - http://dx.doi.org/10.1002/anie.201804067
UR  - http://hdl.handle.net/10044/1/61459
VL  - 58
ER  -

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