Imperial College London
Alternate

Professor Molly Stevens

Faculty of Engineering, Department of Materials

Professor of Biomedical Materials and Regenerative Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6804m.stevens

 
 
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Location

 

208Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Spicer:2018:10.1021/acs.chemrev.8b00253,
author = {Spicer, C and Pashuck, E and Stevens, MM},
doi = {10.1021/acs.chemrev.8b00253},
journal = {Chemical Reviews},
pages = {7702--7743},
title = {Achieving controlled biomolecule-biomaterial conjugation},
url = {http://dx.doi.org/10.1021/acs.chemrev.8b00253},
volume = {118},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The conjugation of biomolecules can impart materials with the bioactivity necessary to modulate specific cell behaviors. While the biological roles of particular polypeptide, oligonucleotide, and glycan structures have been extensively reviewed, along with the influence of attachment on material structure and function, the key role played by the conjugation strategy in determining activity is often overlooked. In this review, we focus on the chemistry of biomolecule conjugation and provide a comprehensive overview of the key strategies for achieving controlled biomaterial functionalization. No universal method exists to provide optimal attachment, and here we will discuss both the relative advantages and disadvantages of each technique. In doing so, we highlight the importance of carefully considering the impact and suitability of a particular technique during biomaterial design.
AU  - Spicer,C
AU  - Pashuck,E
AU  - Stevens,MM
DO  - 10.1021/acs.chemrev.8b00253
EP  - 7743
PY  - 2018///
SN  - 1520-6890
SP  - 7702
TI  - Achieving controlled biomolecule-biomaterial conjugation
T2  - Chemical Reviews
UR  - http://dx.doi.org/10.1021/acs.chemrev.8b00253
UR  - http://hdl.handle.net/10044/1/62613
VL  - 118
ER  -
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