Imperial College London
Alternate

Professor Molly Stevens

Faculty of Engineering, Department of Materials

Professor of Biomedical Materials and Regenerative Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6804m.stevens

 
 
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Location

 

208Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Gray:2018:10.1097/QAD.0000000000001982,
author = {Gray, ER and Bain, R and Varsaneux, O and Peeling, RW and Stevens, MM and Mckendry, RA},
doi = {10.1097/QAD.0000000000001982},
journal = {AIDS},
pages = {2089--2102},
title = {p24 revisited: a landscape review of antigen detection for early HIV diagnosis},
url = {http://dx.doi.org/10.1097/QAD.0000000000001982},
volume = {32},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Despite major advances in HIV testing, early detection of infection at the point of care (PoC) remains a key challenge. While rapid antibody PoC and laboratory-based nucleic acid amplification tests dominate the diagnostics market, the viral capsid protein p24 is recognized as an alternative early virological biomarker of infection. However, the detection of ultra-low levels of p24 at the PoC has proven challenging. Here we review the landscape of p24-diagnostics to identify knowledge gaps and barriers and help shape future research agendas. 574 research papers to May 2018 that propose or evaluate diagnostic assays for p24 were identified and reviewed. We give a brief history of diagnostic development, and the utility of p24 as a biomarker in different populations such as infants, the newly infected, those on pre-exposure prophylaxis and self-testers. We review the performance of commercial p24 assays and consider elements such as immune complex disruption, resource-poor settings, prevalence, and assay antibodies. Emerging and ultrasensitive assays are reviewed and show a number of promising approaches but further translation has been limited. We summarize studies on the health economic benefits of using antigen testing. Finally, we speculate on the future uses of high performance p24 assays, particularly if available in self-test format.
AU  - Gray,ER
AU  - Bain,R
AU  - Varsaneux,O
AU  - Peeling,RW
AU  - Stevens,MM
AU  - Mckendry,RA
DO  - 10.1097/QAD.0000000000001982
EP  - 2102
PY  - 2018///
SN  - 0269-9370
SP  - 2089
TI  - p24 revisited: a landscape review of antigen detection for early HIV diagnosis
T2  - AIDS
UR  - http://dx.doi.org/10.1097/QAD.0000000000001982
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30102659
UR  - https://journals.lww.com/aidsonline/fulltext/10.1097/QAD.0000000000001982
UR  - http://hdl.handle.net/10044/1/61992
VL  - 32
ER  -
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