Imperial College London
Alternate

Professor Molly Stevens

Faculty of Engineering, Department of Materials

Professor of Biomedical Materials and Regenerative Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6804m.stevens

 
 
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Location

 

208Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Loynachan:2019:10.1038/s41565-019-0527-6,
author = {Loynachan, C and Soleimany, AP and Dudani, JS and Lin, Y and Najer, A and Bekdemir, A and Chen, Q and Bhatia, SN and Stevens, M},
doi = {10.1038/s41565-019-0527-6},
journal = {Nature Nanotechnology},
pages = {883--890},
title = {Renal clearable catalytic gold nanoclusters for in vivo disease monitoring},
url = {http://dx.doi.org/10.1038/s41565-019-0527-6},
volume = {14},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Ultra-small gold nanoclusters (AuNCs) have emerged as agile probes for in vivo imaging, asthey exhibit exceptional tumour accumulation and efficient renal clearance properties.However, their intrinsic catalytic activity, which can enable increased detection sensitivity, hasyet to be explored for in vivo sensing. By exploiting the peroxidase-mimicking activity of AuNCsand the precise nanometer size filtration of the kidney, we designed multifunctional proteasenanosensors that respond to disease microenvironments to produce a direct colorimetricurinary readout of disease state in less than 1 h. We monitored the catalytic activity of AuNCsin collected urine of a mouse model of colorectal cancer where tumour-bearing mice showeda 13-fold increase in colorimetric signal compared to healthy mice. Nanosensors wereeliminated completely through hepatic and renal excretion within 4 weeks after injection withno evidence of toxicity. We envision that this modular approach will enable rapid detection ofa diverse range of diseases by exploiting their specific enzymatic signatures.
AU  - Loynachan,C
AU  - Soleimany,AP
AU  - Dudani,JS
AU  - Lin,Y
AU  - Najer,A
AU  - Bekdemir,A
AU  - Chen,Q
AU  - Bhatia,SN
AU  - Stevens,M
DO  - 10.1038/s41565-019-0527-6
EP  - 890
PY  - 2019///
SN  - 1748-3387
SP  - 883
TI  - Renal clearable catalytic gold nanoclusters for in vivo disease monitoring
T2  - Nature Nanotechnology
UR  - http://dx.doi.org/10.1038/s41565-019-0527-6
UR  - https://www.nature.com/articles/s41565-019-0527-6
UR  - http://hdl.handle.net/10044/1/71621
VL  - 14
ER  -
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