Imperial College London
Alternate

Professor Molly Stevens

Faculty of Engineering, Department of Materials

Professor of Biomedical Materials and Regenerative Medicine
 
 
 
//

Contact

 

+44 (0)20 7594 6804m.stevens

 
 
//

Location

 

208Royal School of MinesSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Liu:2020:10.1126/sciadv.aay7608,
author = {Liu, H and Du, Y and St-Pierre, J-P and Bergholt, MS and Autefage, H and Wang, J and Cai, M and Yang, G and Stevens, M and Shengmin, Z},
doi = {10.1126/sciadv.aay7608},
journal = {Science Advances},
pages = {1--15},
title = {Bioenergetic-active materials enhance tissue regeneration by modulating cellular metabolic state},
url = {http://dx.doi.org/10.1126/sciadv.aay7608},
volume = {6},
year = {2020}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Cellular bioenergetics (CBE) plays a critical role in tissue regeneration. Physiologically, an enhanced metabolic state facilitates anabolic biosynthesis and mitosis to accelerate regeneration. However, the development of approaches to reprogram CBE, towards the treatment of substantial tissue injuries, hasbeen limited thus far. Here, we show that induced repair in a rabbit model of weight-bearing bone defects is greatly enhanced using a bioenergetic-active material (BAM) scaffold, compared to commercialized poly (lactic acid) and calcium phosphate ceramic scaffolds. This material was composed of energy-active units that can be released in a sustained degradation-mediated fashion once implanted. By establishing an intramitochondrial metabolic bypass, the internalized energy-active units significantly elevatemitochondria membrane potential (ΔΨm) to supply increased bioenergetic levels and accelerate bone formation. The ready-to-use material developed here represents a highly efficient and easy-to-implement therapeutic approach toward tissue regeneration, withpromise for bench-to-bedside translation.
AU  - Liu,H
AU  - Du,Y
AU  - St-Pierre,J-P
AU  - Bergholt,MS
AU  - Autefage,H
AU  - Wang,J
AU  - Cai,M
AU  - Yang,G
AU  - Stevens,M
AU  - Shengmin,Z
DO  - 10.1126/sciadv.aay7608
EP  - 15
PY  - 2020///
SN  - 2375-2548
SP  - 1
TI  - Bioenergetic-active materials enhance tissue regeneration by modulating cellular metabolic state
T2  - Science Advances
UR  - http://dx.doi.org/10.1126/sciadv.aay7608
UR  - https://advances.sciencemag.org/content/6/13/eaay7608
UR  - http://hdl.handle.net/10044/1/76558
VL  - 6
ER  -
Download