Imperial College London
Alternate

Professor Molly Stevens

Faculty of Engineering, Department of Materials

Professor of Biomedical Materials and Regenerative Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6804m.stevens

 
 
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Location

 

208Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Roberts:2020:10.1039/d0sc00532k,
author = {Roberts, DA and Pilgrim, BS and Dell, TN and Stevens, MM},
doi = {10.1039/d0sc00532k},
journal = {Chemical Science},
pages = {3713--3718},
title = {Dynamic pH responsivity of triazole-based self-immolative linkers},
url = {http://dx.doi.org/10.1039/d0sc00532k},
volume = {11},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Gating the release of chemical payloads in response to transient signals is an important feature of ‘smart’ delivery systems. Herein, we report a triazole-based self-immolative linker that can be reversibly paused or slowed and restarted throughout its elimination cascade in response to pH changes in both organic and organic-aqueous solvents. The linker is conveniently prepared using the alkyne–azide cycloaddition reaction, which introduces a 1,4-triazole ring that expresses a pH-sensitive intermediate during its elimination sequence. Using a series of model compounds, we demonstrate that this intermediate can be switched between active and dormant states depending on the presence of acid or base, cleanly gating the release of payload in response to a fluctuating external stimulus.
AU  - Roberts,DA
AU  - Pilgrim,BS
AU  - Dell,TN
AU  - Stevens,MM
DO  - 10.1039/d0sc00532k
EP  - 3718
PY  - 2020///
SN  - 2041-6520
SP  - 3713
TI  - Dynamic pH responsivity of triazole-based self-immolative linkers
T2  - Chemical Science
UR  - http://dx.doi.org/10.1039/d0sc00532k
UR  - https://pubs.rsc.org/en/content/articlelanding/2020/SC/D0SC00532K#!divAbstract
UR  - http://hdl.handle.net/10044/1/78257
VL  - 11
ER  -
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