Imperial College London
Alternate

Professor Molly Stevens

Faculty of Engineering, Department of Materials

Professor of Biomedical Materials and Regenerative Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6804m.stevens

 
 
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Location

 

208Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Li:2021:10.1016/j.tibtech.2020.06.005,
author = {Li, C and Ouyang, L and Armstrong, J and Stevens, M},
doi = {10.1016/j.tibtech.2020.06.005},
journal = {Trends in Biotechnology},
pages = {150--164},
title = {Advances in the fabrication of biomaterials for gradient tissue engineering},
url = {http://dx.doi.org/10.1016/j.tibtech.2020.06.005},
volume = {39},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Natural tissues and organs exhibit an array of spatial gradients, from the polar-ized neural tube during embryonic development to the osteochondral interfacepresent  at  articulating  joints.  The  strong  structure–function  relationships  inthese heterogeneous tissues have sparked intensive research into the develop-ment of methods that can replicate physiological gradients in engineered tis-sues. In this Review, we consider different gradients present in natural tissuesand discuss their critical importance in functional tissue engineering. Using thisbasis, we consolidate the existing fabrication methods into four categories: addi-tive manufacturing, component redistribution, controlled phase changes, andpostmodification. We have illustrated this with recent examples, highlightedprominent trends in thefield, and outlined a set of criteria and perspectives forgradient fabrication.
AU  - Li,C
AU  - Ouyang,L
AU  - Armstrong,J
AU  - Stevens,M
DO  - 10.1016/j.tibtech.2020.06.005
EP  - 164
PY  - 2021///
SN  - 0167-7799
SP  - 150
TI  - Advances in the fabrication of biomaterials for gradient tissue engineering
T2  - Trends in Biotechnology
UR  - http://dx.doi.org/10.1016/j.tibtech.2020.06.005
UR  - https://www.sciencedirect.com/science/article/pii/S0167779920301694?via%3Dihub
UR  - http://hdl.handle.net/10044/1/80908
VL  - 39
ER  -
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