Imperial College London
Alternate

Professor Molly Stevens

Faculty of Engineering, Department of Materials

Professor of Biomedical Materials and Regenerative Medicine
 
 
 
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Contact

 

+44 (0)20 7594 6804m.stevens

 
 
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Location

 

208Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Finbloom:2020:10.1016/j.addr.2020.06.007,
author = {Finbloom, JA and Sousa, F and Stevens, MM and Desai, TA},
doi = {10.1016/j.addr.2020.06.007},
journal = {Advanced Drug Delivery Reviews},
pages = {89--108},
title = {Engineering the drug carrier biointerface to overcome biological barriers to drug delivery},
url = {http://dx.doi.org/10.1016/j.addr.2020.06.007},
volume = {167},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Micro and nanoscale drug carriers must navigate through a plethora of dynamic biological systems prior to reaching their tissue or disease targets. The biological obstacles to drug delivery come in many forms and include tissue barriers, mucus and bacterial biofilm hydrogels, the immune system, and cellular uptake and intracellular trafficking. The biointerface of drug carriers influences how these carriers navigate and overcome biological barriers for successful drug delivery. In this review, we examine how key material design parameters lead to dynamic biointerfaces and improved drug delivery across biological barriers. We provide a brief overview of approaches used to engineer key physicochemical properties of drug carriers, such as morphology, surface chemistry, and topography, as well as the development of dynamic responsive materials for barrier navigation. We then discuss essential biological barriers and how biointerface engineering can enable drug carriers to better navigate and overcome these barriers to drug delivery.
AU  - Finbloom,JA
AU  - Sousa,F
AU  - Stevens,MM
AU  - Desai,TA
DO  - 10.1016/j.addr.2020.06.007
EP  - 108
PY  - 2020///
SN  - 0169-409X
SP  - 89
TI  - Engineering the drug carrier biointerface to overcome biological barriers to drug delivery
T2  - Advanced Drug Delivery Reviews
UR  - http://dx.doi.org/10.1016/j.addr.2020.06.007
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32535139
UR  - https://www.sciencedirect.com/science/article/pii/S0169409X20300533?via%3Dihub
UR  - http://hdl.handle.net/10044/1/80882
VL  - 167
ER  -
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